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Long non-coding RNAs: new players in cell differentiation and development
Alessandro Fatica,Irene Bozzoni +1 more
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TLDR
The function of lncRNAs in developmental processes, such as in dosage compensation, genomic imprinting, cell differentiation and organogenesis, with a particular emphasis on mammalian development are described.Abstract:
Genomes of multicellular organisms are characterized by the pervasive expression of different types of non-coding RNAs (ncRNAs). Long ncRNAs (lncRNAs) belong to a novel heterogeneous class of ncRNAs that includes thousands of different species. lncRNAs have crucial roles in gene expression control during both developmental and differentiation processes, and the number of lncRNA species increases in genomes of developmentally complex organisms, which highlights the importance of RNA-based levels of control in the evolution of multicellular organisms. In this Review, we describe the function of lncRNAs in developmental processes, such as in dosage compensation, genomic imprinting, cell differentiation and organogenesis, with a particular emphasis on mammalian development.read more
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Circular RNA hsa_circRNA_0007334 is Predicted to Promote MMP7 and COL1A1 Expression by Functioning as a miRNA Sponge in Pancreatic Ductal Adenocarcinoma
Jinghui Yang,Xianling Cong,Ming Ren,Hongyan Sun,Tao Liu,Gaoyang Chen,Qingyu Wang,Zhaoyan Li,Shan Yu,Qiwei Yang +9 more
TL;DR: The present study is the first to propose two regulatory pathways in PDAC: hsa_circRNA_0007334–hsa-miR-144-3p–MMP7 and hsa-MiR-577–COL1A1, which may serve as a competing endogenous RNA to regulate matrix metallopeptidase 7 and collagen type I alpha 1 chain inPDAC.
Journal ArticleDOI
The roles and regulation of Polycomb complexes in neural development
Matthew Corley,Kristen L. Kroll +1 more
TL;DR: The distinct roles that Polycomb repressive complexes play during neurogenesis and gliogenesis are reviewed, while also highlighting recent work describing the molecular mechanisms that govern their dynamic activity in neural development.
Journal ArticleDOI
LncRNA SBF2-AS1 promotes the progression of cervical cancer by regulating miR-361-5p/FOXM1 axis.
TL;DR: It is demonstrated that the SBF2-AS1/miR-361-5p/FOXM1 axis might play an important role in CC progression and might serve as a potential therapeutic target for CC treatment.
Journal ArticleDOI
lincRNA-p21 inhibits invasion and metastasis of hepatocellular carcinoma through Notch signaling-induced epithelial–mesenchymal transition
TL;DR: The expression level of lincRNA‐p21 was investigated in hepatocellular carcinoma (HCC), and its role in invasion of HCC was also explored.
Journal ArticleDOI
Identification and characterization of sORF-encoded polypeptides.
TL;DR: An overview of the results and the future directions in this emerging field of s(m)ORF-encoded polypeptides is provided.
References
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Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
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