Journal ArticleDOI
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
David S. Segal,Arnold J. Mandell +1 more
TLDR
carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections, indicating the importance of their concurrent evaluation, especially during chronic studies.Abstract:
The competitive relationship between d-amphetamine induced stereotypy and locomotor activity indicates the importance of their concurrent evaluation, especially during chronic studies. Repeated injection of 0.5, 1.0, 2.5, 5.0, or 7.5 mg/kg d-amphetamine for 36 successive days, in rats continuously exposed to the experimental chambers, produced a progressive augmentation in stereotypy and/or locomotion (depending on dose) during the 3–4 hr interval following injections (post-injection phase). In contrast, dark phase locomotor activity (8–20 hr after each daily injection) was maximally reduced (30–40% of controls) after the first injection of either 5.0 or 7.5 mg/kg d-amphetamine and gradually declined to this level with repeated injection of 1.0 and 2.5 mg/kg. Carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections. Possible mechanisms underlying these behavioral alterations are discussed.read more
Citations
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Comparison of acute and chronic neurochemical effects of cocaine and cocaine cues in rhesus monkeys and rodents: focus on striatal and cortical dopamine systems.
TL;DR: To best evaluate potential models of addiction, it will be important to also consider data from non-human primates as a more proximal animal model to the human condition, particularly in the greater complexity of cortical development.
Journal ArticleDOI
The D3 dopamine receptor and substance dependence.
TL;DR: It is proposed that down-regulation of D3 dopamine receptor function contributes to sensitization, and this result in part from greater accommodation of the inhibitory D3 receptor “brake” on locomotion, leading to progressive locomotion increase following repeated stimulant exposure.
Journal ArticleDOI
Naltrexone attenuates amphetamine-induced locomotor sensitization in the rat
Jenny Häggkvist,Carl Björkholm,Pia Steensland,Sara Lindholm,Sara Lindholm,Johan Franck,Björn Schilström +6 more
TL;DR: This study showed that NTX attenuates drug‐ and cue‐induced locomotor behavior in amphetamine‐conditioned animals, supporting recent clinical findings that indicated a potential role of NTX as a treatment for amphetamine dependence.
Journal ArticleDOI
Abatement of stimulus perseveration following repeated d-amphetamine treatment: Absence of behaviorally augmented tolerance
Larry Kokkinidis,Hymie Anisman +1 more
TL;DR: Although stimulus factors are involved in the perseverative response, conditioning factors are not of primary relevance in determining the tolerance, it was suggested that the mechanisms which subserve stimulus perseveration are different from those which mediate locomotor activity and stereotypy.
Journal ArticleDOI
Amphetamine sensitization of stress-induced turning in animals given unilateral dopamine transplants in infancy.
TL;DR: It is suggested that amphetamine alters certain properties of the transplanted cells so as to enhance their functional capacity and that stress-induced turning did not develop unless animals were previously exposed to amphetamine.
References
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Journal Article
Tolerance to, and dependence on, some non-opiate psychotropic drugs
Journal Article
The phenomenology of experimentally induced amphetamine psychosis--preliminary observations.
Burton M. Angrist,Samuel Gershon +1 more
Journal Article
Antiamphetamine effects following inhibition of tyrosine hydroxylase
TL;DR: The antiamphetamine effects of α-MT and other tyrosine hydroxylase inhibitors suggest that a critical level of norepinephrine at the receptor is required for amphetamine to exert its customary effects.
Journal ArticleDOI
Amphetamines and related compounds : E. Costa and S. Garattini (Editors.) (Raven Press, New York, 1970, 962 p. $ 28.50)
Journal ArticleDOI
Role of Catecholamines in the Amphetamine Excitatory Response
A. Randrup,I. Munkvad +1 more
TL;DR: The advent of α-methyl para-tyrosine3 (α-MPT), which inhibits the in vivo synthesis of 3,4-dihydroxyphenylalanine (DOPA)—the physiological precursor of the catecholamines—offers a new way of investigating this problem.
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