Journal ArticleDOI
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
David S. Segal,Arnold J. Mandell +1 more
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TLDR
carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections, indicating the importance of their concurrent evaluation, especially during chronic studies.Abstract:
The competitive relationship between d-amphetamine induced stereotypy and locomotor activity indicates the importance of their concurrent evaluation, especially during chronic studies. Repeated injection of 0.5, 1.0, 2.5, 5.0, or 7.5 mg/kg d-amphetamine for 36 successive days, in rats continuously exposed to the experimental chambers, produced a progressive augmentation in stereotypy and/or locomotion (depending on dose) during the 3–4 hr interval following injections (post-injection phase). In contrast, dark phase locomotor activity (8–20 hr after each daily injection) was maximally reduced (30–40% of controls) after the first injection of either 5.0 or 7.5 mg/kg d-amphetamine and gradually declined to this level with repeated injection of 1.0 and 2.5 mg/kg. Carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections. Possible mechanisms underlying these behavioral alterations are discussed.read more
Citations
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Selective Knockout of the Vesicular Monoamine Transporter 2 (Vmat2) Gene in Calbindin2/Calretinin-Positive Neurons Results in Profound Changes in Behavior and Response to Drugs of Abuse.
TL;DR: This work took advantage of the Cre-LoxP system to create a new conditional knockout mouse line in which Vmat2 expression is deleted selectively in Calb2-Cre-positive neurons, and gene targeting of Vmat1 was observed in several distinct monoaminergic areas.
Journal ArticleDOI
Reduction of rat striatal thyrotropin-releasing hormone receptors produced by repeated methamphetamine administration
TL;DR: It is suggested that repeated MAP administration caused lasting dysfunction in the brain TRH system, which may be implicated in the behavioral sensitization.
Investigation of the behavioral processes and neurobiological substrates involved in the motivation for voluntary wheel running in the rat
TL;DR: Overall, rats with limited wheel access showed remarkable alterations in time and rate of running, which appeared to be an anticipatory response to removal of the wheel, which provides new evidence that voluntary wheel running habits are flexible and can be shaped by specific protocol choices.
Journal ArticleDOI
The effects of chronic mescaline administration on operant behavior in the pigeon
TL;DR: Two possible mechanisms underlying this two-stage action of mescaline seen in this and other studies are discussed and the endogenous hallucinogen hypothesis of schizophrenia is considered in light of the existence of tolerance-resistant hallucinogenic drug effects.
References
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Burton M. Angrist,Samuel Gershon +1 more
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Antiamphetamine effects following inhibition of tyrosine hydroxylase
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Role of Catecholamines in the Amphetamine Excitatory Response
A. Randrup,I. Munkvad +1 more
TL;DR: The advent of α-methyl para-tyrosine3 (α-MPT), which inhibits the in vivo synthesis of 3,4-dihydroxyphenylalanine (DOPA)—the physiological precursor of the catecholamines—offers a new way of investigating this problem.
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