Journal ArticleDOI
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
David S. Segal,Arnold J. Mandell +1 more
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TLDR
carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections, indicating the importance of their concurrent evaluation, especially during chronic studies.Abstract:
The competitive relationship between d-amphetamine induced stereotypy and locomotor activity indicates the importance of their concurrent evaluation, especially during chronic studies. Repeated injection of 0.5, 1.0, 2.5, 5.0, or 7.5 mg/kg d-amphetamine for 36 successive days, in rats continuously exposed to the experimental chambers, produced a progressive augmentation in stereotypy and/or locomotion (depending on dose) during the 3–4 hr interval following injections (post-injection phase). In contrast, dark phase locomotor activity (8–20 hr after each daily injection) was maximally reduced (30–40% of controls) after the first injection of either 5.0 or 7.5 mg/kg d-amphetamine and gradually declined to this level with repeated injection of 1.0 and 2.5 mg/kg. Carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections. Possible mechanisms underlying these behavioral alterations are discussed.read more
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Shift from inhibition to excitation in the neostriatum but not in the nucleus accumbens following long-term amphethamine
Kevin D. Alloway,George V. Rebec +1 more
TL;DR: Electrophysiological and neurochemical changes are discussed in relation to the known involvement of these sites in the dose-dependent behavioral alterations that accompany repeated amphetamine injections in rats pretreated with these doses.
Journal ArticleDOI
Behavioral sensitization to ethanol results in cross-sensitization to MK-801 but not to NMDA administered intra-accumbens.
TL;DR: The goal of the present study was to analyze the involvement of accumbal glutamate NMDA receptors in the locomotion behavioral response to an NMDA agonist or to anNMDA antagonist in mice previously treated with ethanol, and observe cross-sensitization between repeated ethanol treatment and the intra-NAc administration of MK-801.
Journal ArticleDOI
Hippocampal glucocorticoid receptor mRNA is up-regulated by acute and down-regulated by chronic amphetamine treatment
TL;DR: A role for hippocampal GR mRNA in the development of behavioral sensitization is supported by the effects of five daily injections of amphetamine on GR mRNA of adult Sprague-Dawley rats.
Journal ArticleDOI
Reversal of amphetamine-induced circling preference in trained circling rats
Bryan K. Yamamoto,Curt R. Freed +1 more
TL;DR: Investigating the effect of training on amphetamine-induced behavioral and biochemical asymmetries in male Sprague-Dawley rats found intrinsic striatal lateralization is not resistant to behavioral modification and both the behavioral andochemical asymmetry can be reversed by circling training.
Journal ArticleDOI
The effect of chronic administration of d‐amphetamine on regional changes in catecholamines in the rat brain
TL;DR: Most of the brain areas showed a decrease in the dopamine concentration apart from the olfactory lobes which showed an increase and the midbrain and hippocampus which were largely unchanged, suggesting that the turnover of dopamine was decreased.
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Antiamphetamine effects following inhibition of tyrosine hydroxylase
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Role of Catecholamines in the Amphetamine Excitatory Response
A. Randrup,I. Munkvad +1 more
TL;DR: The advent of α-methyl para-tyrosine3 (α-MPT), which inhibits the in vivo synthesis of 3,4-dihydroxyphenylalanine (DOPA)—the physiological precursor of the catecholamines—offers a new way of investigating this problem.
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