Journal ArticleDOI
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
David S. Segal,Arnold J. Mandell +1 more
Reads0
Chats0
TLDR
carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections, indicating the importance of their concurrent evaluation, especially during chronic studies.Abstract:
The competitive relationship between d-amphetamine induced stereotypy and locomotor activity indicates the importance of their concurrent evaluation, especially during chronic studies. Repeated injection of 0.5, 1.0, 2.5, 5.0, or 7.5 mg/kg d-amphetamine for 36 successive days, in rats continuously exposed to the experimental chambers, produced a progressive augmentation in stereotypy and/or locomotion (depending on dose) during the 3–4 hr interval following injections (post-injection phase). In contrast, dark phase locomotor activity (8–20 hr after each daily injection) was maximally reduced (30–40% of controls) after the first injection of either 5.0 or 7.5 mg/kg d-amphetamine and gradually declined to this level with repeated injection of 1.0 and 2.5 mg/kg. Carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections. Possible mechanisms underlying these behavioral alterations are discussed.read more
Citations
More filters
Journal ArticleDOI
In vivo microdialysis reveals a diminished amphetamine-induced DA response corresponding to behavioral sensitization produced by repeated amphetamine pretreatment
David S. Segal,Ronald Kuczenski +1 more
TL;DR: The results are consistent with the previous suggestion that there is a dissociation between the DA and behavioral responses to amphetamine, and therefore that other neurotransmitter systems and/or mechanisms significantly contribute to the amphetamine response profile.
Journal ArticleDOI
Methamphetamine-Associated Psychosis
Kathleen M. Grant,Tricia D. LeVan,Sandra M. Wells,Ming Li,Scott F. Stoltenberg,Howard E. Gendelman,Gustavo Carlo,Rick A. Bevins +7 more
TL;DR: Key gaps in understanding of METH-associated psychosis are identified and potential directions for future research are suggested to identify key gaps in the understanding of MAP.
Journal ArticleDOI
Psychostimulant sensitization: differential changes in accumbal shell and core dopamine
TL;DR: The results suggest that behavioral sensitization might result from reciprocal changes in the response of nucleus accumbens dopamine in the shell and in the core to drug challenge.
Journal ArticleDOI
Stimulant-induced psychosis, the dopamine theory of schizophrenia, and the habenula
TL;DR: It is argued that alterations in these pathways are ideal candidates for producing the behaviors which occur during psychosis and that future considerations of the circuitry underlying psychoses need to include this highly important but relatively neglected system.
Journal ArticleDOI
Coping and the Stress-Induced Potentiation of Stimulant Stereotypy in the Rat
AJ MacLennan,Steven F. Maier +1 more
TL;DR: It has been shown that stressed rats display increased stereotypy in response to a subsequent amphetamine challenge, and evidence is presented showing that stress potentiates cocaine stereotypy as well, which has implications for the role of stress and coping in amphetamine and cocaine psychoses, endogenous psychoses
References
More filters
Journal Article
Tolerance to, and dependence on, some non-opiate psychotropic drugs
Journal Article
The phenomenology of experimentally induced amphetamine psychosis--preliminary observations.
Burton M. Angrist,Samuel Gershon +1 more
Journal Article
Antiamphetamine effects following inhibition of tyrosine hydroxylase
TL;DR: The antiamphetamine effects of α-MT and other tyrosine hydroxylase inhibitors suggest that a critical level of norepinephrine at the receptor is required for amphetamine to exert its customary effects.
Journal ArticleDOI
Amphetamines and related compounds : E. Costa and S. Garattini (Editors.) (Raven Press, New York, 1970, 962 p. $ 28.50)
Journal ArticleDOI
Role of Catecholamines in the Amphetamine Excitatory Response
A. Randrup,I. Munkvad +1 more
TL;DR: The advent of α-methyl para-tyrosine3 (α-MPT), which inhibits the in vivo synthesis of 3,4-dihydroxyphenylalanine (DOPA)—the physiological precursor of the catecholamines—offers a new way of investigating this problem.
Related Papers (5)
Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis
Terry E. Robinson,Jill B. Becker +1 more
The neural basis of drug craving: An incentive-sensitization theory of addiction
Increasing effects of repetitive cocaine administration in the rat
Robert M. Post,Harvey Rose +1 more