Journal ArticleDOI
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
David S. Segal,Arnold J. Mandell +1 more
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TLDR
carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections, indicating the importance of their concurrent evaluation, especially during chronic studies.Abstract:
The competitive relationship between d-amphetamine induced stereotypy and locomotor activity indicates the importance of their concurrent evaluation, especially during chronic studies. Repeated injection of 0.5, 1.0, 2.5, 5.0, or 7.5 mg/kg d-amphetamine for 36 successive days, in rats continuously exposed to the experimental chambers, produced a progressive augmentation in stereotypy and/or locomotion (depending on dose) during the 3–4 hr interval following injections (post-injection phase). In contrast, dark phase locomotor activity (8–20 hr after each daily injection) was maximally reduced (30–40% of controls) after the first injection of either 5.0 or 7.5 mg/kg d-amphetamine and gradually declined to this level with repeated injection of 1.0 and 2.5 mg/kg. Carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections. Possible mechanisms underlying these behavioral alterations are discussed.read more
Citations
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Journal ArticleDOI
Deprivation-dependent effects of amphetamine on concurrent measures of feeding and activity
TL;DR: The findings suggest that the amount of food deprivation differentially influences difference concurrent measures of amphetamine effects as well as differentially affecting the interrelationship of the drug's effects.
Journal ArticleDOI
Lack of tolerance or sensitization to the effects of chronic d-amphetamine on substantia nigra self-stimulation.
TL;DR: To the extent that self-stimulation in substantia nigra reflects the functional state of dopaminergic neurotransmission, progressive augmentation of activity and stereotypy by repeated d-amphetamine administration may not involve dopaminerential processes.
Journal ArticleDOI
Striatal dopamine metabolism in response to apomorphine: the effects of repeated amphetamine pretreatment.
TL;DR: The results suggest that repeated AMPH pretreatment does not alter DA autoreceptor sensitivity; and interpretations of the decline in striatal DA metabolites at high doses of APO, in terms of activation of postsynaptic DA receptors, may require re-evaluation.
Journal ArticleDOI
Comments on "Amphetamine models of paranoid schizophrenia": a precautionary note.
Book ChapterDOI
The Pharmacological Profile of Some Psychomotor Stimulant Drugs Including Chemical, Neurophysiological, Biochemical, and Toxicological Aspects
S. Garattini,R. Samanin +1 more
TL;DR: No ideal drugs presently exist although there are some, such as amphetamine, which have played a historically important role in elucidating central biochemical and physiologic functions, particularly those connected with the neurochemical transmission linked to monoamines.
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Antiamphetamine effects following inhibition of tyrosine hydroxylase
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Journal ArticleDOI
Role of Catecholamines in the Amphetamine Excitatory Response
A. Randrup,I. Munkvad +1 more
TL;DR: The advent of α-methyl para-tyrosine3 (α-MPT), which inhibits the in vivo synthesis of 3,4-dihydroxyphenylalanine (DOPA)—the physiological precursor of the catecholamines—offers a new way of investigating this problem.
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