Journal ArticleDOI
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
David S. Segal,Arnold J. Mandell +1 more
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TLDR
carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections, indicating the importance of their concurrent evaluation, especially during chronic studies.Abstract:
The competitive relationship between d-amphetamine induced stereotypy and locomotor activity indicates the importance of their concurrent evaluation, especially during chronic studies. Repeated injection of 0.5, 1.0, 2.5, 5.0, or 7.5 mg/kg d-amphetamine for 36 successive days, in rats continuously exposed to the experimental chambers, produced a progressive augmentation in stereotypy and/or locomotion (depending on dose) during the 3–4 hr interval following injections (post-injection phase). In contrast, dark phase locomotor activity (8–20 hr after each daily injection) was maximally reduced (30–40% of controls) after the first injection of either 5.0 or 7.5 mg/kg d-amphetamine and gradually declined to this level with repeated injection of 1.0 and 2.5 mg/kg. Carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections. Possible mechanisms underlying these behavioral alterations are discussed.read more
Citations
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Does dizocilpine (MK-801) selectively block the enhanced responsiveness to repeated amphetamine administration?
TL;DR: It is suggested that rather than blocking the development of sensitization, MK-801 pretreatment may produce a unique behavioral augmentation that is apparent during coadministration and that persists for up to 48 hr in the response to amphetamine challenge.
Journal ArticleDOI
Environment-specific enhancement of the hyperactivity induced by systemic or intra-VTA morphine injections in rats preexposed to amphetamine
Jane Stewart,Paul Vezina +1 more
TL;DR: The environment-specific cross-sensitization between the effects of amphetamine and morphine seen in this experiment suggests that the development and expression of drug-induced sensitization can come under the control of conditioned stimuli.
Journal ArticleDOI
Methylphenidate: diurnal effects on locomotor and stereotypic behavior in the rat.
TL;DR: The locomotor stimulating effects of the lower doses were similar whether given during the light or dark phase, despite the large diurnal variations in baseline activity between the activity phases, and the highest dose had the most robust effect on locomotor activity.
Journal ArticleDOI
Acute and chronic continuous methamphetamine have different long-term behavioral and neurochemical consequences.
TL;DR: The data suggest that the behavioral cross-sensitization seen in the methamphetamine injection rats could be in part due to the increased potency of cocaine in blocking dopamine reuptake and in increasing dopamine release.
Journal ArticleDOI
Ondansetron Given in the Acute Withdrawal from a Repeated Cocaine Sensitization Dosing Regimen Reverses the Expression of Sensitization and Inhibits Self-administration
TL;DR: Ondansetron may be a useful treatment for cocaine addicts who have undergone previous sensitization periods and inhibited cocaine self-administration on each of the following days.
References
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Journal Article
Tolerance to, and dependence on, some non-opiate psychotropic drugs
Journal Article
The phenomenology of experimentally induced amphetamine psychosis--preliminary observations.
Burton M. Angrist,Samuel Gershon +1 more
Journal Article
Antiamphetamine effects following inhibition of tyrosine hydroxylase
TL;DR: The antiamphetamine effects of α-MT and other tyrosine hydroxylase inhibitors suggest that a critical level of norepinephrine at the receptor is required for amphetamine to exert its customary effects.
Journal ArticleDOI
Amphetamines and related compounds : E. Costa and S. Garattini (Editors.) (Raven Press, New York, 1970, 962 p. $ 28.50)
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Role of Catecholamines in the Amphetamine Excitatory Response
A. Randrup,I. Munkvad +1 more
TL;DR: The advent of α-methyl para-tyrosine3 (α-MPT), which inhibits the in vivo synthesis of 3,4-dihydroxyphenylalanine (DOPA)—the physiological precursor of the catecholamines—offers a new way of investigating this problem.
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