Journal ArticleDOI
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
David S. Segal,Arnold J. Mandell +1 more
TLDR
carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections, indicating the importance of their concurrent evaluation, especially during chronic studies.Abstract:
The competitive relationship between d-amphetamine induced stereotypy and locomotor activity indicates the importance of their concurrent evaluation, especially during chronic studies. Repeated injection of 0.5, 1.0, 2.5, 5.0, or 7.5 mg/kg d-amphetamine for 36 successive days, in rats continuously exposed to the experimental chambers, produced a progressive augmentation in stereotypy and/or locomotion (depending on dose) during the 3–4 hr interval following injections (post-injection phase). In contrast, dark phase locomotor activity (8–20 hr after each daily injection) was maximally reduced (30–40% of controls) after the first injection of either 5.0 or 7.5 mg/kg d-amphetamine and gradually declined to this level with repeated injection of 1.0 and 2.5 mg/kg. Carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections. Possible mechanisms underlying these behavioral alterations are discussed.read more
Citations
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Salmon Calcitonin Attenuates Some Behavioural Responses to Nicotine in Male Mice.
Cajsa Aranäs,Jesper Vestlund,Sarah Witley,Christian E. Edvardsson,Aimilia Lydia Kalafateli,Elisabet Jerlhag +5 more
TL;DR: In this paper, the effects of salmon calcitonin (sCT) on nicotine-induced locomotor stimulation and sensitisation as well as dopamine release in the nucleus accumbens (NAc) shell were investigated.
Selective dopamine D3 receptor antagonist YQA14 inhibits morphine-induced behavioral sensitization in wild type,but not in dopamine D3 receptor knockout mice
TL;DR: It is demonstrated that blockade or knockout of the D3R inhibits morphine-induced behavior sensitization, suggesting that D 3R plays an important role in the pathogenesis and etiology of morphine addiction, and it might be a potential target for clinical management of opioid addiction.
Journal ArticleDOI
Effects of caffeine on tactile startle in rats.
TL;DR: The effects of graded doses of caffeine on tactile startle responding were examined in rats given 121 air-puff stimuli at 15 second intervals and it was found that the effect was maximal 15 minutes after the subcutaneous injection.
Journal ArticleDOI
Striatal dopamine receptor sensitivity after subchronic fencamfamine in the rat
TL;DR: It is indicated that subchronic fencamfamine treatment leads to a desensitization of postsynaptic DA receptors in rat striatum and a slight but significant reduction in the total dopamine receptor content in the striatum labelled by [3H]spiroperidol.
References
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Role of Catecholamines in the Amphetamine Excitatory Response
A. Randrup,I. Munkvad +1 more
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