Journal ArticleDOI
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
David S. Segal,Arnold J. Mandell +1 more
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TLDR
carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections, indicating the importance of their concurrent evaluation, especially during chronic studies.Abstract:
The competitive relationship between d-amphetamine induced stereotypy and locomotor activity indicates the importance of their concurrent evaluation, especially during chronic studies. Repeated injection of 0.5, 1.0, 2.5, 5.0, or 7.5 mg/kg d-amphetamine for 36 successive days, in rats continuously exposed to the experimental chambers, produced a progressive augmentation in stereotypy and/or locomotion (depending on dose) during the 3–4 hr interval following injections (post-injection phase). In contrast, dark phase locomotor activity (8–20 hr after each daily injection) was maximally reduced (30–40% of controls) after the first injection of either 5.0 or 7.5 mg/kg d-amphetamine and gradually declined to this level with repeated injection of 1.0 and 2.5 mg/kg. Carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections. Possible mechanisms underlying these behavioral alterations are discussed.read more
Citations
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Stages of constant amphetamine intoxication: Delayed appearance of abnormal social behaviors in rat colonies
TL;DR: This late phase of constant amphetamine intoxication in rats has a number of similarities to amphetamine psychosis in humans, and can serve as a useful animal model for the study of its biochemical correlates.
Journal ArticleDOI
A dopaminergic mechanism is involved in the 'anxiogenic-like' response induced by chronic amphetamine treatment: a behavioral and neurochemical study.
TL;DR: Previous exposure to chronic AMPH treatment induces an increased emotional response following a conflict situation, and dopamine D(1) receptors are mainly involved in chronicAMPH-induced changes in the behavior displayed in EPM test, suggesting an interaction between GABAergic and dopaminergic mechanisms may be implicated in neurochemical and behavioral changes induced by chronic AM PH treatment.
Journal ArticleDOI
Effects of drug experience on drug induced conditioned taste aversions: studies with amphetamine and fenfluramine.
Andrew J. Goudie,E. W. Thornton +1 more
TL;DR: Conditioned taste aversions established in rats to 0.1% sodium saccharin by intra-peritoneal injections of dl-fenfluramine hydrochloride or d-amphetamine sulphate were found to be significantly attenuated, but not abolished altogether, by chronic pretreatment with the specific drug.
Journal ArticleDOI
Lasting effects of repeated ∆9‐tetrahydrocannabinol vapour inhalation during adolescence in male and female rats
Jacques D. Nguyen,Jacques D. Nguyen,Kevin M. Creehan,Kevin M. Creehan,Tony M. Kerr,Michael A. Taffe,Michael A. Taffe +6 more
TL;DR: Growing legalization of cannabis for medical and recreational purposes, combined with decreasing perceptions of harm, makes it increasingly important to determine the consequences of frequent adolescent exposure for motivated behaviour and lasting tolerance in response to THC.
Journal ArticleDOI
Dissociation between long-lasting behavioral sensitization to amphetamine and impulsive choice in rats performing a delay-discounting task
TL;DR: The results suggest that one behavioral consequence of repeated AMPH exposure—sensitization—does not overlap with another potential outcome—increased impulsivity, and the neuroadaptations known to be associated with sensitization may be somewhat distinct from those that lead to changes in impulsive choice.
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Antiamphetamine effects following inhibition of tyrosine hydroxylase
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Role of Catecholamines in the Amphetamine Excitatory Response
A. Randrup,I. Munkvad +1 more
TL;DR: The advent of α-methyl para-tyrosine3 (α-MPT), which inhibits the in vivo synthesis of 3,4-dihydroxyphenylalanine (DOPA)—the physiological precursor of the catecholamines—offers a new way of investigating this problem.
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