Journal ArticleDOI
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
David S. Segal,Arnold J. Mandell +1 more
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carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections, indicating the importance of their concurrent evaluation, especially during chronic studies.Abstract:
The competitive relationship between d-amphetamine induced stereotypy and locomotor activity indicates the importance of their concurrent evaluation, especially during chronic studies. Repeated injection of 0.5, 1.0, 2.5, 5.0, or 7.5 mg/kg d-amphetamine for 36 successive days, in rats continuously exposed to the experimental chambers, produced a progressive augmentation in stereotypy and/or locomotion (depending on dose) during the 3–4 hr interval following injections (post-injection phase). In contrast, dark phase locomotor activity (8–20 hr after each daily injection) was maximally reduced (30–40% of controls) after the first injection of either 5.0 or 7.5 mg/kg d-amphetamine and gradually declined to this level with repeated injection of 1.0 and 2.5 mg/kg. Carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections. Possible mechanisms underlying these behavioral alterations are discussed.read more
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Dissertation
Augmenter la vitesse d’injection de la cocaïne favorise l’apparition de comportements de consommation caractéristiques de la toxicomanie
TL;DR: Results show that increasing the speed at which cocaine is delivered to the brain leads to greater drug intake and increased willingness to expend effort to obtain the drug, two important symptoms of addiction.
Journal ArticleDOI
Differential biochemical and behavioral effects of single and chronic administration of amphetamine and apomorphine.
TL;DR: The results support the view that behavioural changes observed after AP single and repeated treatment are a result of DA autoreceptors subsensitivity, and the behavioural changes detected after AM treatments are probably related to mechanisms other than the development ofDA autoreceptor subsensitivity.
Journal ArticleDOI
Ethanol-induced changes in synaptic amino acid neurotransmitter levels in the nucleus accumbens of differentially sensitized mice
Mina G. Nashed,Dipashree Chatterjee,Dipashree Chatterjee,Diana Nguyen,Diana Nguyen,Daria Oleinichenko,Daria Oleinichenko,Mustansir Diwan,José N. Nobrega +8 more
TL;DR: These data suggest that the profile of amino acid neurotransmitters in the NAc of LS and HS mice significantly differs, and contributes to the understanding of factors that confer susceptibility/resilience to alcohol use disorder.
Methamphetamine-induced deficits in social interaction are not observed following abstinence from single or repeated exposures
TL;DR: In this paper, the authors assess social interaction following acute and repeated methamphetamine (MA) administration and find that an acute injection of MA decreases social interaction and simultaneously increases avoidance behavior, which supports a link between psychostimulant use and impaired social functioning.
Dissertation
Neural substrates of amphetamine induced impulsive behaviour
TL;DR: It is demonstrated that different patterns of amphetamine administration produce different effects on the duration of behavioural disinhibition in rats, and further, that amphetamine induced activation of the D2 receptors within the nucleus accumbens core mediates Amphetamine induced behaviouraldisinhibition on the symmetrically reinforced Go/No-go task.
References
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Journal Article
Antiamphetamine effects following inhibition of tyrosine hydroxylase
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Journal ArticleDOI
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Role of Catecholamines in the Amphetamine Excitatory Response
A. Randrup,I. Munkvad +1 more
TL;DR: The advent of α-methyl para-tyrosine3 (α-MPT), which inhibits the in vivo synthesis of 3,4-dihydroxyphenylalanine (DOPA)—the physiological precursor of the catecholamines—offers a new way of investigating this problem.
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