Journal ArticleDOI
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
David S. Segal,Arnold J. Mandell +1 more
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carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections, indicating the importance of their concurrent evaluation, especially during chronic studies.Abstract:
The competitive relationship between d-amphetamine induced stereotypy and locomotor activity indicates the importance of their concurrent evaluation, especially during chronic studies. Repeated injection of 0.5, 1.0, 2.5, 5.0, or 7.5 mg/kg d-amphetamine for 36 successive days, in rats continuously exposed to the experimental chambers, produced a progressive augmentation in stereotypy and/or locomotion (depending on dose) during the 3–4 hr interval following injections (post-injection phase). In contrast, dark phase locomotor activity (8–20 hr after each daily injection) was maximally reduced (30–40% of controls) after the first injection of either 5.0 or 7.5 mg/kg d-amphetamine and gradually declined to this level with repeated injection of 1.0 and 2.5 mg/kg. Carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections. Possible mechanisms underlying these behavioral alterations are discussed.read more
Citations
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Dissertation
Glutamatergic mechanisms in behavioural sensitization to ethanol
TL;DR: It is suggested that nucleus accumbens (NAc) glutamate may not be necessary for the development of EtOH sensitization, but it appears essential for the expression of a sensitized response.
Journal ArticleDOI
Effects of dopamine receptor antagonism and amphetamine-induced psychomotor sensitization on sign- and goal-tracking after extended training.
TL;DR: In this paper, the effects of dopamine D1-like and D2-like receptor antagonism on the expression of sign-tracking and goal-tracking conditioned responses following extended Pavlovian conditioned approach (PCA) training were investigated.
Book ChapterDOI
Behavioral Techniques in Pharmacological and Neuropharmacological Analysis
Hymie Anisman,Angelo Santi +1 more
Dissertation
Advancing rodent models of the behaviours and the neurobiological pathology associated with schizophrenia
TL;DR: It is found that prenatal glutamatergic blockade results in impairments similar to those seen in other animal models, as well as patients with schizophrenia, and working memory as measured by a delay-non-match to place task, is not driven by prefronto-cortical dopamine transmission.
Journal ArticleDOI
Effects of repeated treatment with methamphetamine plus scopolamine and methamphetamine on behavioral sensitization and conditioning
TL;DR: The results suggest that methamphetamine plus scopolamine-induced pronounced behavioral sensitization may produce an enhanced conditioning and that exteroceptive conditioned stimulus-interoceptive unconditioned stimulus associations may provide an important source for drug conditioning.
References
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Tolerance to, and dependence on, some non-opiate psychotropic drugs
Journal Article
The phenomenology of experimentally induced amphetamine psychosis--preliminary observations.
Burton M. Angrist,Samuel Gershon +1 more
Journal Article
Antiamphetamine effects following inhibition of tyrosine hydroxylase
TL;DR: The antiamphetamine effects of α-MT and other tyrosine hydroxylase inhibitors suggest that a critical level of norepinephrine at the receptor is required for amphetamine to exert its customary effects.
Journal ArticleDOI
Amphetamines and related compounds : E. Costa and S. Garattini (Editors.) (Raven Press, New York, 1970, 962 p. $ 28.50)
Journal ArticleDOI
Role of Catecholamines in the Amphetamine Excitatory Response
A. Randrup,I. Munkvad +1 more
TL;DR: The advent of α-methyl para-tyrosine3 (α-MPT), which inhibits the in vivo synthesis of 3,4-dihydroxyphenylalanine (DOPA)—the physiological precursor of the catecholamines—offers a new way of investigating this problem.
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