Journal ArticleDOI
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
David S. Segal,Arnold J. Mandell +1 more
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TLDR
carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections, indicating the importance of their concurrent evaluation, especially during chronic studies.Abstract:
The competitive relationship between d-amphetamine induced stereotypy and locomotor activity indicates the importance of their concurrent evaluation, especially during chronic studies. Repeated injection of 0.5, 1.0, 2.5, 5.0, or 7.5 mg/kg d-amphetamine for 36 successive days, in rats continuously exposed to the experimental chambers, produced a progressive augmentation in stereotypy and/or locomotion (depending on dose) during the 3–4 hr interval following injections (post-injection phase). In contrast, dark phase locomotor activity (8–20 hr after each daily injection) was maximally reduced (30–40% of controls) after the first injection of either 5.0 or 7.5 mg/kg d-amphetamine and gradually declined to this level with repeated injection of 1.0 and 2.5 mg/kg. Carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections. Possible mechanisms underlying these behavioral alterations are discussed.read more
Citations
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Classical conditioning, decay and extinction of cocaine-induced hyperactivity and stereotypy.
Gordon A. Barr,Nansie S. Sharpless,Stanley Cooper,Stanley R. Schiff,William Paredes,Wagner H. Bridger +5 more
TL;DR: The behavioral results demonstrate that, in a classical conditioning paradigm, previously neutral stimuli can elicit behaviors similar to those induced by cocaine and that certain conditioned responses show time related decline.
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Induction of a salt appetite alters dendritic morphology in nucleus accumbens and sensitizes rats to amphetamine.
TL;DR: It is indicated that a strong natural motivator, sodium depletion and associated salt appetite, also leads to alterations in neurons in nucleus accumbens, leading to enhanced psychostimulant responses to amphetamine.
Journal ArticleDOI
Withdrawal from chronic amphetamine elevates baseline intracranial self-stimulation thresholds
Roy A. Wise,Elizabeth Munn +1 more
TL;DR: It is confirmed that chronic amphetamine treatment results in a dependence syndrome characterized in part by a phasic depression in the brain mechanism mediating the reinforcing effects of lateral hypothalamic electrical stimulation.
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Enhanced extracellular dopamine level may be the fundamental neuropharmacological basis of cross-behavioral sensitization between methamphetamine and cocaine - an in vivo dialysis study in freely moving rats
TL;DR: Results suggest that an enhancement in striatal DA efflux may play an important role in cross-behavioral sensitization between methamphetamine (MAP) and cocaine.
Journal ArticleDOI
Receptor alterations and drug tolerance.
TL;DR: It is argued that a multidisciplinary approach is required to elucidate the role of receptor alterations in drug tolerance and that numerous investigators have reported alterations in receptor binding following chronic drug treatment but these two phenomena have seldom been studied in the same experiment.
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Role of Catecholamines in the Amphetamine Excitatory Response
A. Randrup,I. Munkvad +1 more
TL;DR: The advent of α-methyl para-tyrosine3 (α-MPT), which inhibits the in vivo synthesis of 3,4-dihydroxyphenylalanine (DOPA)—the physiological precursor of the catecholamines—offers a new way of investigating this problem.
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