Journal ArticleDOI
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
David S. Segal,Arnold J. Mandell +1 more
TLDR
carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections, indicating the importance of their concurrent evaluation, especially during chronic studies.Abstract:
The competitive relationship between d-amphetamine induced stereotypy and locomotor activity indicates the importance of their concurrent evaluation, especially during chronic studies. Repeated injection of 0.5, 1.0, 2.5, 5.0, or 7.5 mg/kg d-amphetamine for 36 successive days, in rats continuously exposed to the experimental chambers, produced a progressive augmentation in stereotypy and/or locomotion (depending on dose) during the 3–4 hr interval following injections (post-injection phase). In contrast, dark phase locomotor activity (8–20 hr after each daily injection) was maximally reduced (30–40% of controls) after the first injection of either 5.0 or 7.5 mg/kg d-amphetamine and gradually declined to this level with repeated injection of 1.0 and 2.5 mg/kg. Carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections. Possible mechanisms underlying these behavioral alterations are discussed.read more
Citations
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Journal ArticleDOI
Cellular and behavioral effects of D2 dopamine receptor hydrophobic eigenmode-targeted peptide ligands.
Arnold J. Mandell,Arnold J. Mandell,Karen A. Selz,Karen A. Selz,Michael J. Owens,Becky Kinkead,Michael F. Shlesinger,David A. Gutman,Vani Arguragi +8 more
TL;DR: Patterns in G-protein-coupled receptors' hydrophobically transformed amino-acid sequences can be computationally characterized as hierarchies of autocorrelation waves, ‘hydrophobic eigenmodes,’ using autocovariance matrix decomposition and all poles power spectral and wavelet transformations.
Journal ArticleDOI
Evidence that alpha-methyl-p-tyramine is implicated in behavioural augmentation to amphetamine
TL;DR: Findings suggest that AMT derived from previous doses of AMPHET may play a role in the phenomena of behavioural augmentation observed after chronic administration of AM PHET.
Journal ArticleDOI
Medial septal lesions in rats enhance locomotor sensitization to amphetamine.
TL;DR: Although medial septal lesions occasionally enhance locomotor responses to moderate doses of amphetamine prior to sensitization, a main effect of these lesions is to further enhance the effects of locomotor sensitization to amphetamine.
Journal ArticleDOI
Toward a neuropsychopharmacology of habituation: A vertical integration
TL;DR: This essay is a cross-disciplinary exploration of desensitization and habituation processes in the nervous system with a major focus on a reconfiguration of several kinds of data into a common language that emphasizes organizational dynamics among constituent elements as reflected by their statistical behavior.
References
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Role of Catecholamines in the Amphetamine Excitatory Response
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