Journal ArticleDOI
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
David S. Segal,Arnold J. Mandell +1 more
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TLDR
carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections, indicating the importance of their concurrent evaluation, especially during chronic studies.Abstract:
The competitive relationship between d-amphetamine induced stereotypy and locomotor activity indicates the importance of their concurrent evaluation, especially during chronic studies. Repeated injection of 0.5, 1.0, 2.5, 5.0, or 7.5 mg/kg d-amphetamine for 36 successive days, in rats continuously exposed to the experimental chambers, produced a progressive augmentation in stereotypy and/or locomotion (depending on dose) during the 3–4 hr interval following injections (post-injection phase). In contrast, dark phase locomotor activity (8–20 hr after each daily injection) was maximally reduced (30–40% of controls) after the first injection of either 5.0 or 7.5 mg/kg d-amphetamine and gradually declined to this level with repeated injection of 1.0 and 2.5 mg/kg. Carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections. Possible mechanisms underlying these behavioral alterations are discussed.read more
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Amphetamine-induced sensitization of hypertension and lamina terminalis neuroinflammation
TL;DR: The results suggest that a history of stimulant use may predispose individuals to developing hypertension by promoting neuroinflammation and upregulating activity of the RAAS in the lamina terminalis.
Journal ArticleDOI
Effects of haloperidol and cocaine pretreatments on brain distribution and kinetics of [11C]methamphetamine in methamphetamine sensitized dog: Application of PET to drug pharmacokinetic study
Hitoshi Nakamura,Takanori Hishinuma,Yoshihisa Tomioka,Shunji Ishiwata,Tatsuo Ido,Ren Iwata,Yoshihito Funaki,Masatoshi Itoh,Takehiko Fujiwara,Kazuhiko Yanai,Mitsumoto Sato,Yohtaro Numachi,Sumiko Yoshida,Michinao Mizugaki +13 more
TL;DR: The results suggest haloperidol and cocaine can change the cerebral pharmacokinetic profile of MAP in the behavioral-sensitized dog and the variations of MAP-accumulation may affect the development or expression ofMAP-induced behavioral sensitization.
Journal ArticleDOI
Cocaine-induced rausch: overt behaviour and plasma concentrations in rhesus monkeys.
TL;DR: The results showed dose-response relationships for both plasma concentrations of cocaine and for the total number of overt behavioural signs, and the plasma concentrations were in the range reported for human cocaine abusers.
Journal ArticleDOI
Age-dependent effects of repeated methamphetamine exposure on locomotor activity and attentional function in rats
Azadeh Nazari,Cristian Pérez-Fernández,Pilar Flores,Margarita Moreno,Fernando Sánchez-Santed +4 more
TL;DR: Investigation of the possible short- and long-term effects of Meth at two distinct points of adolescence stage (early versus late) on locomotor activity in adolescent rats and attentional functions in their adulthood found Meth administration during late adolescence stage may cause prolonged attentional deficits in adulthood.
Journal ArticleDOI
Patterns of locomotor and stereotypic behavior during continuous amphetamine administration in rats.
TL;DR: Continuous administration of amphetamine seems to reliably increase the frequency of behaviors which are rarely observed after acute or chronic amphetamine, which has important implications since administration of AMPH to rats has been suggested to be an animal model of schizophrenia.
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Role of Catecholamines in the Amphetamine Excitatory Response
A. Randrup,I. Munkvad +1 more
TL;DR: The advent of α-methyl para-tyrosine3 (α-MPT), which inhibits the in vivo synthesis of 3,4-dihydroxyphenylalanine (DOPA)—the physiological precursor of the catecholamines—offers a new way of investigating this problem.
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