Journal ArticleDOI
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
David S. Segal,Arnold J. Mandell +1 more
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TLDR
carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections, indicating the importance of their concurrent evaluation, especially during chronic studies.Abstract:
The competitive relationship between d-amphetamine induced stereotypy and locomotor activity indicates the importance of their concurrent evaluation, especially during chronic studies. Repeated injection of 0.5, 1.0, 2.5, 5.0, or 7.5 mg/kg d-amphetamine for 36 successive days, in rats continuously exposed to the experimental chambers, produced a progressive augmentation in stereotypy and/or locomotion (depending on dose) during the 3–4 hr interval following injections (post-injection phase). In contrast, dark phase locomotor activity (8–20 hr after each daily injection) was maximally reduced (30–40% of controls) after the first injection of either 5.0 or 7.5 mg/kg d-amphetamine and gradually declined to this level with repeated injection of 1.0 and 2.5 mg/kg. Carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections. Possible mechanisms underlying these behavioral alterations are discussed.read more
Citations
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Journal ArticleDOI
Short-term regulation of hydroxylase cofactor activity in rat brain.
TL;DR: A conformational stability‐dependent variable degree of stoichiometric coupling between quinonoid dihydropteridine reductase and tyrosine hydroxylase is proposed as a short‐latency influence on hydroxyase cofactor levels.
Book ChapterDOI
Behavioral Sensitization to Addictive Drugs: Clinical Relevance and Methodological Aspects
Tamara J. Phillips,Tamara J. Phillips,Raúl Pastor,Raúl Pastor,Angela C. Scibelli,Cheryl Reed,Ernesto Tarragon +6 more
Journal ArticleDOI
Alterations in β-endorphin-induced locomotor activity in morphine-tolerant rats
R.G. Browne,D.S. Segal +1 more
TL;DR: The results suggest that the same underlying mechanisms subserve the behavioral effects produced by opiates and opioid peptides.
Journal ArticleDOI
A behavioural study of the changes in the central nervous system of mice after subchronic treatment with the selective dopamine autoreceptor agonist 3-PPP ( dl -3-[3-hydroxyphenyl]-N-n-propylpiperidine)
TL;DR: 3-PPP-pretreated mice were more sensitive to the activating effects ofd- methamphetamine, and this increased sensitivity was blocked by pretreatment with reserpine, which may be due to a reduction in the feedback control exerted by the DA released by thed-amphetamine due to the DA autoreceptors having become subsensitive.
Journal ArticleDOI
Effect of chlorpromazine on mouse ambulatory activity sensitization caused by (+)‐amphetamine
TL;DR: The development of sensitization to the ambulation‐increasing effect of (+)‐amphetamine was found to be dose‐dependently inhibited when 1 or 2 mg kg−1 chlorpromazine was administered concomitantly, and the sensitization was almost completely suppressed when co‐administered with 4 mg kg‐1 chlor Promazine.
References
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Burton M. Angrist,Samuel Gershon +1 more
Journal Article
Antiamphetamine effects following inhibition of tyrosine hydroxylase
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Journal ArticleDOI
Amphetamines and related compounds : E. Costa and S. Garattini (Editors.) (Raven Press, New York, 1970, 962 p. $ 28.50)
Journal ArticleDOI
Role of Catecholamines in the Amphetamine Excitatory Response
A. Randrup,I. Munkvad +1 more
TL;DR: The advent of α-methyl para-tyrosine3 (α-MPT), which inhibits the in vivo synthesis of 3,4-dihydroxyphenylalanine (DOPA)—the physiological precursor of the catecholamines—offers a new way of investigating this problem.
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