Journal ArticleDOI
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
David S. Segal,Arnold J. Mandell +1 more
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TLDR
carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections, indicating the importance of their concurrent evaluation, especially during chronic studies.Abstract:
The competitive relationship between d-amphetamine induced stereotypy and locomotor activity indicates the importance of their concurrent evaluation, especially during chronic studies. Repeated injection of 0.5, 1.0, 2.5, 5.0, or 7.5 mg/kg d-amphetamine for 36 successive days, in rats continuously exposed to the experimental chambers, produced a progressive augmentation in stereotypy and/or locomotion (depending on dose) during the 3–4 hr interval following injections (post-injection phase). In contrast, dark phase locomotor activity (8–20 hr after each daily injection) was maximally reduced (30–40% of controls) after the first injection of either 5.0 or 7.5 mg/kg d-amphetamine and gradually declined to this level with repeated injection of 1.0 and 2.5 mg/kg. Carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections. Possible mechanisms underlying these behavioral alterations are discussed.read more
Citations
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Journal ArticleDOI
Co-administration of either a selective D1 or D2 dopamine antagonist with methamphetamine prevents methamphetamine-induced behavioral sensitization and neurochemical change, studied by in vivo intracerebral dialysis
Takashi Hamamura,Kazufumi Akiyama,Kiyoshi Akimoto,Kenichi Kashihara,Kazuya Okumura,Hiroshi Ujike,Saburo Otsuki +6 more
TL;DR: The results indicate that both D1 and D2 dopamine receptors play a role in the formation of behavioral sensitization, but with different mechanisms.
Book ChapterDOI
Toward a Psychobiology of Transcendence: God in the Brain
TL;DR: One approach assumes a world of hidden realities, impenetrable to be understood by conjecture and test, observations evaluated for their consistency with hypothetical constructs; the other requires an intuitive grasp of the essence, insightful awareness of the thing itself as discussed by the authors.
Journal ArticleDOI
Reverse tolerance to stimulant-induced abnormal behavior
TL;DR: In two experiments, behavior induced by apomorphine was potentiated during the initial post-injection period following a course of repeated, daily administrations of d-amphetamine or cocaine, suggesting the development of supersensitive dopaminergic post-synaptic mechanisms.
Journal ArticleDOI
The long-term effects of repeated amphetamine treatment in vivo on amphetamine, KCl and electrical stimulation evoked striatal dopamine release in vitro
TL;DR: It was found that AMPH pretreatment produced a long-lasting enhancement in striatal DA release evoked by AMPH, KCl or electrical field stimulation, and the basal rate of DA efflux was not altered by pretreatment condition.
Journal ArticleDOI
Strain differences in the behavioral responses of male rats to chronically administered methylphenidate
TL;DR: Investigation of strain differences in the locomotor responses to MPD among three rat strains found that rat strains play a significant role in the response to acute and chronic administration of MPD.
References
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Tolerance to, and dependence on, some non-opiate psychotropic drugs
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The phenomenology of experimentally induced amphetamine psychosis--preliminary observations.
Burton M. Angrist,Samuel Gershon +1 more
Journal Article
Antiamphetamine effects following inhibition of tyrosine hydroxylase
TL;DR: The antiamphetamine effects of α-MT and other tyrosine hydroxylase inhibitors suggest that a critical level of norepinephrine at the receptor is required for amphetamine to exert its customary effects.
Journal ArticleDOI
Amphetamines and related compounds : E. Costa and S. Garattini (Editors.) (Raven Press, New York, 1970, 962 p. $ 28.50)
Journal ArticleDOI
Role of Catecholamines in the Amphetamine Excitatory Response
A. Randrup,I. Munkvad +1 more
TL;DR: The advent of α-methyl para-tyrosine3 (α-MPT), which inhibits the in vivo synthesis of 3,4-dihydroxyphenylalanine (DOPA)—the physiological precursor of the catecholamines—offers a new way of investigating this problem.
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