Journal ArticleDOI
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
David S. Segal,Arnold J. Mandell +1 more
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TLDR
carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections, indicating the importance of their concurrent evaluation, especially during chronic studies.Abstract:
The competitive relationship between d-amphetamine induced stereotypy and locomotor activity indicates the importance of their concurrent evaluation, especially during chronic studies. Repeated injection of 0.5, 1.0, 2.5, 5.0, or 7.5 mg/kg d-amphetamine for 36 successive days, in rats continuously exposed to the experimental chambers, produced a progressive augmentation in stereotypy and/or locomotion (depending on dose) during the 3–4 hr interval following injections (post-injection phase). In contrast, dark phase locomotor activity (8–20 hr after each daily injection) was maximally reduced (30–40% of controls) after the first injection of either 5.0 or 7.5 mg/kg d-amphetamine and gradually declined to this level with repeated injection of 1.0 and 2.5 mg/kg. Carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections. Possible mechanisms underlying these behavioral alterations are discussed.read more
Citations
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Tolerance and sensitization to the behavioral effects of cocaine in rats : Relationship to benzodiazepine receptors
TL;DR: Significant differences in benzodiazepine receptor binding measured autoradiographically using [3H]flumazenil were observed between rats that received cocaine before or after each session, suggesting that the development of tolerance and sensitization may be mediated through changes in benzoceptor receptors in discrete brain regions.
Journal ArticleDOI
Effects of amphetamine at the beginning of the light cycle on multiple indices of motor activity in the rat.
TL;DR: The range of variables and the establishment of baseline values at the time of injection for each rat provides the potential to characterize circadian patterns of locomotor activity and chronopharmacologic effects of drugs on motor activity, including sensitization and tolerance.
Journal ArticleDOI
The effect of chronic bromocriptine and L-dopa on spiperone binding and apomorphine-induced stereotypy.
TL;DR: It is concluded that agonist induction of subsensitivity in the DA system is difficult to reproduce and may depend on highly specific dosage conditions and treatment schedules.
Journal ArticleDOI
Sensitization to d-amphetamine after its repeated administration: evidence in EEG and behaviour
TL;DR: It was found that under a certain dosage and schedule, cocaine could produce a shift from a D1-characteristic to a D2-like EEG pattern, and if the same is true for d-amphetamine, this drug was studied.
Journal ArticleDOI
Diminished reaction to a novel stimulus during amphetamine withdrawal in rats.
TL;DR: This experiment determined whether reaction to a novel stimulus was diminished in a dose-dependent fashion following 8 consecutive days of d-amphetamine administration, and whether this reduction did not seem to depend on the level of amphetamine-induced sterotypy at the end of the drug administration period.
References
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Burton M. Angrist,Samuel Gershon +1 more
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Antiamphetamine effects following inhibition of tyrosine hydroxylase
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Journal ArticleDOI
Role of Catecholamines in the Amphetamine Excitatory Response
A. Randrup,I. Munkvad +1 more
TL;DR: The advent of α-methyl para-tyrosine3 (α-MPT), which inhibits the in vivo synthesis of 3,4-dihydroxyphenylalanine (DOPA)—the physiological precursor of the catecholamines—offers a new way of investigating this problem.
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