Journal ArticleDOI
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
David S. Segal,Arnold J. Mandell +1 more
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TLDR
carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections, indicating the importance of their concurrent evaluation, especially during chronic studies.Abstract:
The competitive relationship between d-amphetamine induced stereotypy and locomotor activity indicates the importance of their concurrent evaluation, especially during chronic studies. Repeated injection of 0.5, 1.0, 2.5, 5.0, or 7.5 mg/kg d-amphetamine for 36 successive days, in rats continuously exposed to the experimental chambers, produced a progressive augmentation in stereotypy and/or locomotion (depending on dose) during the 3–4 hr interval following injections (post-injection phase). In contrast, dark phase locomotor activity (8–20 hr after each daily injection) was maximally reduced (30–40% of controls) after the first injection of either 5.0 or 7.5 mg/kg d-amphetamine and gradually declined to this level with repeated injection of 1.0 and 2.5 mg/kg. Carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections. Possible mechanisms underlying these behavioral alterations are discussed.read more
Citations
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Amphetamine psychosis and schizophrenia: a dual model.
Larry Kokkinidis,Hymie Anisman +1 more
TL;DR: It was hypothesized that amphetamine-induced psychosis and the symptomatology associated with schizophrenia are related to alterations in both norepinephrine and dopamine activity.
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Acute and chronic amphetamine treatments modulate striatal dopamine receptor binding sites
D.R. Howlett,Stefan R. Nahorski +1 more
Journal ArticleDOI
Modulation of drug-induced sensitization processes by endogenous opioid systems.
TL;DR: It is shown that behavioural sensitization to morphine and cocaine is modulated by endogenous kappa-opioid systems, and the involvement of endogenous opioid systems in the initiation of sensitized responses on the neurochemical level, i.e., within the mesolimbic dopaminergic system, as well as on the behavioural level.
Journal ArticleDOI
Dopamine D-1 and D-2 receptors in relation to reward and performance: a case for the D-1 receptor as a primary site of therapeutic action of neuroleptic drugs.
TL;DR: Dopamine receptor subtypes and neuroleptic drugs, including D-1 and D-2 receptors, and their roles in reward and performance, and the role of dopamine in these roles are described.
Journal ArticleDOI
Progressive behavioral changes during chronic lidocaine administration: relationship to kindling.
TL;DR: Chronic, five times weekly administration of lidocaine to rats resulted in the progressive development of abnormal eating behavior and seizures, and experimental rats became omniphagic, eating significantly more feces, straw, and gauze than controls.
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Burton M. Angrist,Samuel Gershon +1 more
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Antiamphetamine effects following inhibition of tyrosine hydroxylase
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Role of Catecholamines in the Amphetamine Excitatory Response
A. Randrup,I. Munkvad +1 more
TL;DR: The advent of α-methyl para-tyrosine3 (α-MPT), which inhibits the in vivo synthesis of 3,4-dihydroxyphenylalanine (DOPA)—the physiological precursor of the catecholamines—offers a new way of investigating this problem.
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