Journal ArticleDOI
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
David S. Segal,Arnold J. Mandell +1 more
TLDR
carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections, indicating the importance of their concurrent evaluation, especially during chronic studies.Abstract:
The competitive relationship between d-amphetamine induced stereotypy and locomotor activity indicates the importance of their concurrent evaluation, especially during chronic studies. Repeated injection of 0.5, 1.0, 2.5, 5.0, or 7.5 mg/kg d-amphetamine for 36 successive days, in rats continuously exposed to the experimental chambers, produced a progressive augmentation in stereotypy and/or locomotion (depending on dose) during the 3–4 hr interval following injections (post-injection phase). In contrast, dark phase locomotor activity (8–20 hr after each daily injection) was maximally reduced (30–40% of controls) after the first injection of either 5.0 or 7.5 mg/kg d-amphetamine and gradually declined to this level with repeated injection of 1.0 and 2.5 mg/kg. Carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections. Possible mechanisms underlying these behavioral alterations are discussed.read more
Citations
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Journal ArticleDOI
Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression
TL;DR: The dopamine system is unique among the brain's modulatory systems in that it has discrete projections to specific brain regions involved in motor behaviour, cognition and emotion.
Journal ArticleDOI
Self-inhibition by dopaminergic neurons.
TL;DR: Animals and Plants, L. H. Gilbert and P. Raven, Eds.
Journal ArticleDOI
Dopaminergic stimulation disrupts sensorimotor gating in the rat.
TL;DR: A connection between sensorimotor gating, as measured by prepulse inhibition, and dopaminergic overactivity is suggested, supporting suggestions that information processing deficits in schizophrenia may be responsible for some psychotic symptoms and their effective treatment by antipsychotic D2 dopamine antagonists.
Journal ArticleDOI
Interchangeability of Stress and Amphetamine in Sensitization
TL;DR: It is suggested that amphetamine and at least some stressors may be interchangeable in their ability to induce a sensitization, and the possibility that stress might be a common variable contributing to both amphetamine psychosis and some forms of schizophrenia is raised.
Journal ArticleDOI
Blockade of "reverse tolerance" to cocaine and amphetamine by MK-801.
TL;DR: The data suggest that the glutamate system participates in the mechanism of "reverse tolerance" to the dopaminergic effects of cocaine and amphetamine, as well as to the convulsant effect of cocaine.
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