Journal ArticleDOI
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
David S. Segal,Arnold J. Mandell +1 more
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TLDR
carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections, indicating the importance of their concurrent evaluation, especially during chronic studies.Abstract:
The competitive relationship between d-amphetamine induced stereotypy and locomotor activity indicates the importance of their concurrent evaluation, especially during chronic studies. Repeated injection of 0.5, 1.0, 2.5, 5.0, or 7.5 mg/kg d-amphetamine for 36 successive days, in rats continuously exposed to the experimental chambers, produced a progressive augmentation in stereotypy and/or locomotion (depending on dose) during the 3–4 hr interval following injections (post-injection phase). In contrast, dark phase locomotor activity (8–20 hr after each daily injection) was maximally reduced (30–40% of controls) after the first injection of either 5.0 or 7.5 mg/kg d-amphetamine and gradually declined to this level with repeated injection of 1.0 and 2.5 mg/kg. Carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections. Possible mechanisms underlying these behavioral alterations are discussed.read more
Citations
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Adrenergic control of motor activity: effects of PNMT inhibition upon open field behavior in the rat.
TL;DR: Two inhibitors of brain PNMT were given to rats in doses which caused equivalent reductions in enzyme activity, and central adrenergic (epinephrine containing) system may be necessary for normal open field behavior.
Journal ArticleDOI
Amphetamine-induced stereotypy: reply to Rebec and Bashore.
Larry Kokkinidis,Hymie Anisman +1 more
Journal ArticleDOI
The effect of age-related factors on behavior induced by cocaine.
TL;DR: It was concluded that prolongation of CIB, which has been attributed to receptor supersensitivity, may reflect age-related factors, as heavier, older rats show prolonged CIB upon initial injection.
Journal ArticleDOI
Enhancement of apomorphine and l-amphetamine-induced behaviors by magnesium.
TL;DR: The results demonstrate that magnesium dose dependently increases the potency of these drugs by producing greater behavioral effects at certain drug doses, by producing shifts to the left in dose-response functions, and by producing decreases in the ED50 as dose of magnesium increases.
Journal ArticleDOI
Early handling and maternal behavior: effect on d-amphetamine responsiveness in rats.
Henry L. Schreiber,Robert W. Bell,Gibson Wood,Richard H. Carlson,Linda L. Wright,Michael Kufner,Ramiro Villescas +6 more
TL;DR: Results indicated that behavioral manipulations early in life may influence responsiveness to d-amphetamine in adulthood, either directly or through associated changes in maternal behavior.
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Role of Catecholamines in the Amphetamine Excitatory Response
A. Randrup,I. Munkvad +1 more
TL;DR: The advent of α-methyl para-tyrosine3 (α-MPT), which inhibits the in vivo synthesis of 3,4-dihydroxyphenylalanine (DOPA)—the physiological precursor of the catecholamines—offers a new way of investigating this problem.
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