Journal ArticleDOI
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
David S. Segal,Arnold J. Mandell +1 more
TLDR
carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections, indicating the importance of their concurrent evaluation, especially during chronic studies.Abstract:
The competitive relationship between d-amphetamine induced stereotypy and locomotor activity indicates the importance of their concurrent evaluation, especially during chronic studies. Repeated injection of 0.5, 1.0, 2.5, 5.0, or 7.5 mg/kg d-amphetamine for 36 successive days, in rats continuously exposed to the experimental chambers, produced a progressive augmentation in stereotypy and/or locomotion (depending on dose) during the 3–4 hr interval following injections (post-injection phase). In contrast, dark phase locomotor activity (8–20 hr after each daily injection) was maximally reduced (30–40% of controls) after the first injection of either 5.0 or 7.5 mg/kg d-amphetamine and gradually declined to this level with repeated injection of 1.0 and 2.5 mg/kg. Carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections. Possible mechanisms underlying these behavioral alterations are discussed.read more
Citations
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Journal ArticleDOI
The characteristics of reverse tolerance to the ambulation-increasing effect of cocaine after repeated administration in mice
TL;DR: The enhancement of the effect progressed rapidly and the maximal reverse tolerance was observed at the 3rd-4th administration and this enhancement lasted at least one month, and Cross-reverse tolerance occurred between COC and methamphetamine.
Enduri~ ~ancement in frontal cortex ~ine utilization in an animi ~of amphetami~ psychosis
TL;DR: It is reported that in rats the repeated intermittent administration of amphetamine produces a long:lasting enhancement in medial frontal cortex dopamine utilization, which suggests that AMP produces a very long-lasting change in some neural system(s) involved in the psychotomimetic effects of stimulants.
References
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The phenomenology of experimentally induced amphetamine psychosis--preliminary observations.
Burton M. Angrist,Samuel Gershon +1 more
Journal Article
Antiamphetamine effects following inhibition of tyrosine hydroxylase
TL;DR: The antiamphetamine effects of α-MT and other tyrosine hydroxylase inhibitors suggest that a critical level of norepinephrine at the receptor is required for amphetamine to exert its customary effects.
Journal ArticleDOI
Amphetamines and related compounds : E. Costa and S. Garattini (Editors.) (Raven Press, New York, 1970, 962 p. $ 28.50)
Journal ArticleDOI
Role of Catecholamines in the Amphetamine Excitatory Response
A. Randrup,I. Munkvad +1 more
TL;DR: The advent of α-methyl para-tyrosine3 (α-MPT), which inhibits the in vivo synthesis of 3,4-dihydroxyphenylalanine (DOPA)—the physiological precursor of the catecholamines—offers a new way of investigating this problem.
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