Journal ArticleDOI
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
David S. Segal,Arnold J. Mandell +1 more
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TLDR
carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections, indicating the importance of their concurrent evaluation, especially during chronic studies.Abstract:
The competitive relationship between d-amphetamine induced stereotypy and locomotor activity indicates the importance of their concurrent evaluation, especially during chronic studies. Repeated injection of 0.5, 1.0, 2.5, 5.0, or 7.5 mg/kg d-amphetamine for 36 successive days, in rats continuously exposed to the experimental chambers, produced a progressive augmentation in stereotypy and/or locomotion (depending on dose) during the 3–4 hr interval following injections (post-injection phase). In contrast, dark phase locomotor activity (8–20 hr after each daily injection) was maximally reduced (30–40% of controls) after the first injection of either 5.0 or 7.5 mg/kg d-amphetamine and gradually declined to this level with repeated injection of 1.0 and 2.5 mg/kg. Carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections. Possible mechanisms underlying these behavioral alterations are discussed.read more
Citations
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Long-term L-dopa pretreatment of mice: central receptor subsensitivity or supersensitivity?
TL;DR: It is suggested that dopaminergic changes are not of consequence in the activity induced by dexamphetamine in l-Dopa-pretreated animals, and marked dopamine receptor sensitivity changes seem not to be of primary importance for l-Catecholaminergic hyperactivity in l
Journal ArticleDOI
Alterations of spontaneous neuronal activity in the caudate-putamen, nucleus accumbens and amygdaloid complex of rats produced by D-amphetamine.
TL;DR: Changes in spontaneous neuronal activity in the caudate-putamen, accumbens nucleus and amygdaloid complex of immunobilized, locally anesthetized rats were recorded following intraperitoneal injection of d-amphetamine sulfate and the alleged role of the nigro-neostriatal mesolimbic dopamine systems in the amphetamine behavioral response is discussed.
Journal ArticleDOI
Long-term effects of cocaine experience on neuroplasticity in the nucleus accumbens core of addiction-prone rats
Maria Waselus,Shelly B. Flagel,Jakub P. Jedynak,Huda Akil,Terry E. Robinson,Stanley J. Watson +5 more
TL;DR: Structural plasticity associated with prolonged cocaine abstinence varies markedly in two selected strains of rats that vary on numerous traits relevant to addiction, indicating genetic factors that contribute to individual variation in the behavioral response to cocaine also influence cocaine-induced structural plasticity.
Journal ArticleDOI
Interaction of food deprivation with different measures of amphetamine effects
TL;DR: The findings suggest that the amount of food deprivation differentially influences different general measures fo amphetamine effects as well as differentially affecting the interrelationship of Amphetamine effects.
Journal ArticleDOI
Relationship between amphetamine and environmentally induced stereotypies in pigs.
TL;DR: The study investigated the relationship between the behavioural response to a standard dose of amphetamine and environmentally induced stereotypies in pigs, and suggests that pigs differ in their predisposition to develop environmentallyinduced stereotypies, and that this is related to catecholaminergic systems in the brain.
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Role of Catecholamines in the Amphetamine Excitatory Response
A. Randrup,I. Munkvad +1 more
TL;DR: The advent of α-methyl para-tyrosine3 (α-MPT), which inhibits the in vivo synthesis of 3,4-dihydroxyphenylalanine (DOPA)—the physiological precursor of the catecholamines—offers a new way of investigating this problem.
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