Journal ArticleDOI
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
David S. Segal,Arnold J. Mandell +1 more
Reads0
Chats0
TLDR
carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections, indicating the importance of their concurrent evaluation, especially during chronic studies.Abstract:
The competitive relationship between d-amphetamine induced stereotypy and locomotor activity indicates the importance of their concurrent evaluation, especially during chronic studies. Repeated injection of 0.5, 1.0, 2.5, 5.0, or 7.5 mg/kg d-amphetamine for 36 successive days, in rats continuously exposed to the experimental chambers, produced a progressive augmentation in stereotypy and/or locomotion (depending on dose) during the 3–4 hr interval following injections (post-injection phase). In contrast, dark phase locomotor activity (8–20 hr after each daily injection) was maximally reduced (30–40% of controls) after the first injection of either 5.0 or 7.5 mg/kg d-amphetamine and gradually declined to this level with repeated injection of 1.0 and 2.5 mg/kg. Carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections. Possible mechanisms underlying these behavioral alterations are discussed.read more
Citations
More filters
Journal ArticleDOI
Influence of novel and habituated testing conditions on cocaine sensitization.
TL;DR: Cocaine sensitization may reflect a progressive reversal of the behavioral suppression caused by habituation to aspects of the testing situation or to some form of situational anxiety that precludes normal exploratory responses.
Journal ArticleDOI
Persistant effects of amphetamine on cerebellar Purkinje neurons following chronic administration
TL;DR: It is demonstrated that chronic amphetamine can lead to very long-term changes in neuronal activity, and it is suggested that these changes may be mediated, in part, by the noradrenergic transmitter systems.
Journal ArticleDOI
The effects of infusions of CART 55-102 into the basolateral amygdala on amphetamine-induced conditioned place preference in rats.
TL;DR: Both the affective properties of intra-BLA CART 55–102 and its ability to either facilitate or block AMPH reward are dose dependent.
Journal ArticleDOI
Pre- and post-junctional supersensitivity: differentiation by intraventricular infusions of norepinephrine and methoxamine.
David S. Segal,Mark A. Geyer +1 more
TL;DR: The results indicate that the increased responsiveness to NE induced by 6-OHDA is due to enhanced postsynaptic receptor sensitivity rather than to a loss of presynaptic uptake inactivation.
Journal ArticleDOI
Individual differences in ethanol locomotor sensitization are associated with dopamine D1 receptor intra-cellular signaling of DARPP-32 in the nucleus accumbens.
TL;DR: The data suggest that an enduring increase in the sensitivity of the dopamine D1 receptor intracellular pathway sensitivity represents a neurobiological correlate associated with the development of locomotor sensitization to ethanol.
References
More filters
Journal Article
Tolerance to, and dependence on, some non-opiate psychotropic drugs
Journal Article
The phenomenology of experimentally induced amphetamine psychosis--preliminary observations.
Burton M. Angrist,Samuel Gershon +1 more
Journal Article
Antiamphetamine effects following inhibition of tyrosine hydroxylase
TL;DR: The antiamphetamine effects of α-MT and other tyrosine hydroxylase inhibitors suggest that a critical level of norepinephrine at the receptor is required for amphetamine to exert its customary effects.
Journal ArticleDOI
Amphetamines and related compounds : E. Costa and S. Garattini (Editors.) (Raven Press, New York, 1970, 962 p. $ 28.50)
Journal ArticleDOI
Role of Catecholamines in the Amphetamine Excitatory Response
A. Randrup,I. Munkvad +1 more
TL;DR: The advent of α-methyl para-tyrosine3 (α-MPT), which inhibits the in vivo synthesis of 3,4-dihydroxyphenylalanine (DOPA)—the physiological precursor of the catecholamines—offers a new way of investigating this problem.
Related Papers (5)
Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis
Terry E. Robinson,Jill B. Becker +1 more
The neural basis of drug craving: An incentive-sensitization theory of addiction
Increasing effects of repetitive cocaine administration in the rat
Robert M. Post,Harvey Rose +1 more