Journal ArticleDOI
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
David S. Segal,Arnold J. Mandell +1 more
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TLDR
carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections, indicating the importance of their concurrent evaluation, especially during chronic studies.Abstract:
The competitive relationship between d-amphetamine induced stereotypy and locomotor activity indicates the importance of their concurrent evaluation, especially during chronic studies. Repeated injection of 0.5, 1.0, 2.5, 5.0, or 7.5 mg/kg d-amphetamine for 36 successive days, in rats continuously exposed to the experimental chambers, produced a progressive augmentation in stereotypy and/or locomotion (depending on dose) during the 3–4 hr interval following injections (post-injection phase). In contrast, dark phase locomotor activity (8–20 hr after each daily injection) was maximally reduced (30–40% of controls) after the first injection of either 5.0 or 7.5 mg/kg d-amphetamine and gradually declined to this level with repeated injection of 1.0 and 2.5 mg/kg. Carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections. Possible mechanisms underlying these behavioral alterations are discussed.read more
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Book ChapterDOI
Nonstriatal dopamine mechanisms in the response to repeated d-amphetamine administration
TL;DR: In this article, the authors found that the locomotor response to amphetamine (0.5, 1.0, 2.5 and 5.5 mg/kg) was significantly decreased, whereas the measures of stereotypy were unaltered.
Journal ArticleDOI
QUANTIFICATION OF DOPAMINE D1 AND D2 RECEPTOR mRNA LEVELS ASSOCIATED WITH THE DEVELOPMENT OF BEHAVIORAL SENSITIZATION IN AMPHETAMINE TREATED RATS
Neil M. Richtand,Neil M. Richtand,John R. Kelsoe,John R. Kelsoe,Ronald Kuczenski,David S. Segal +5 more
TL;DR: The results suggest that behavioral sensitization to amphetamine is not mediated through transcriptional regulation of D1 or D2 mRNA levels in caudate/putamen.
Journal ArticleDOI
The effect of chronic administration and withdrawal of amphetamine on cerebral dopamine receptor sensitivity.
TL;DR: This data, showing that chronic amphetamine treatment can induce persistent changes in dopamine receptor sensitivity, can be interpreted in terms of increased striatal receptor sensitivity or as a decreased response of dopamine receptors in the nucleus accumbens.
Journal ArticleDOI
Crayfish Self-Administer Amphetamine in a Spatially Contingent Task
TL;DR: This work demonstrates automated implementation of a spatially contingent, operant drug self-administration paradigm in crayfish, which provides a powerful tool to explore comparative perspectives in drug-sensitive reward, the mechanisms of learning underlying the addictive cycle, and phylogenetically conserved vulnerabilities to psychostimulant compounds.
Journal ArticleDOI
Sensitization to the behavioural effects of cocaine: alterations in tyrosine hydroxylase or endogenous opioid mRNAs are not necessarily involved.
D. Alvarez Fischer,M. K. H. Schäfer,Boris Ferger,S. Groß,Robert W. Westermann,E. Weihe,K. Kuschinsky +6 more
TL;DR: The results suggest that sensitization phenomena to cocaine are not necessarily connected with alterations in the dopaminergic activity in the mesolimbic system or in the transcription of precursors of endogenous opioid peptides which are located downstream of the dopamine synapses.
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Role of Catecholamines in the Amphetamine Excitatory Response
A. Randrup,I. Munkvad +1 more
TL;DR: The advent of α-methyl para-tyrosine3 (α-MPT), which inhibits the in vivo synthesis of 3,4-dihydroxyphenylalanine (DOPA)—the physiological precursor of the catecholamines—offers a new way of investigating this problem.
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