Journal ArticleDOI
Manipulation of intestinal microbiome as potential treatment for insulin resistance and type 2 diabetes.
TLDR
In this article, the authors explore the role of the intestinal microbiome and bacterial metabolites in the pathogenesis and treatment of these conditions and summarize research focused on how to modulate the IM through diet, prebiotics, probiotics, synbiotics and fecal microbiota transplant in order to treat IR and T2D.Abstract:
Increasing evidence suggests that the intestinal microbiome (IM) and bacterial metabolites may influence glucose homeostasis, energy expenditure and the intestinal barrier integrity and lead to the presence of systemic low-grade inflammation, all of which can contribute to insulin resistance (IR) and type 2 diabetes (T2D). The purpose of this review is to explore the role of the IM and bacterial metabolites in the pathogenesis and treatment of these conditions. This review summarizes research focused on how to modulate the IM through diet, prebiotics, probiotics, synbiotics and fecal microbiota transplant in order to treat IR and T2D. There is an abundance of evidence suggesting a role for IM in the pathogenesis of IR and T2D based on reviewed studies using various methods to modulate IM and metabolites. However, the results are inconsistent. Future research should further assess this relationship.read more
Citations
More filters
Journal ArticleDOI
The Effects of Curcumin on Diabetes Mellitus: A Systematic Review.
Ledyane Taynara Marton,Laís Maria Pescinini-e-Salzedas,Maria Eduarda Côrtes Camargo,Sandra Maria Barbalho,Jesselina Francisco dos Santos Haber,Renata Vargas Sinatora,Cláudia Rucco Penteado Detregiachi,Raul José Silva Girio,Daniela Vieira Buchaim,Patrícia Cincotto dos Santos Bueno +9 more
TL;DR: In this article, the effects of Curcuma longa or curcumin on patients with Type II diabetes mellitus were systematically reviewed, and the final selection included sixteen studies that fulfilled the inclusion criteria.
Journal ArticleDOI
Gut modulation based anti-diabetic effects of carboxymethylated wheat bran dietary fiber in high-fat diet/streptozotocin-induced diabetic mice and their potential mechanisms.
Xiao-Xiao Li,Xiu-Xiu Zhang,Rui Zhang,Zhi-Jing Ni,Elnur Elam,Kiran Thakur,Kiran Thakur,Carlos L. Cespedes-Acuña,Jian-Guo Zhang,Jian-Guo Zhang,Zhao-Jun Wei,Zhao-Jun Wei +11 more
TL;DR: In this paper, the effect of carboxymethylated wheat bran dietary fibers (DFs) on mice with type 2 diabetes (T2D) and their possible hypoglycemic mechanism was explored.
Journal ArticleDOI
Prediabetes in Adolescents: Prevalence, Management and Diabetes Prevention Strategies.
TL;DR: This paper found an 8% risk of progression from prediabetes to Type 2 diabetes mellitus (T2DM) over a 3-year period, with other studies finding an increased risk of developing T2DM over the same period.
Journal ArticleDOI
Recent Advances in the Treatment of Insulin Resistance Targeting Molecular and Metabolic Pathways: Fighting a Losing Battle?
TL;DR: This review paper aims to provide critical, concise, but comprehensive insights into the advances in the treatment of IR that were achieved in the last months.
Journal ArticleDOI
Supplementation of 1-Kestose Modulates the Gut Microbiota Composition to Ameliorate Glucose Metabolism in Obesity-Prone Hosts.
Ayako Watanabe,Takumi Tochio,Yoshihiro Kadota,Motoki Takahashi,Yasuyuki Kitaura,Hirohito Ishikawa,Takanori Yasutake,Masahiro Nakano,Hiroe Shinohara,Kudo Toru,Yuichiro Nishimoto,Yoshinori Mizuguchi,Akihito Endo,Yoshiharu Shimomura +13 more
TL;DR: In this paper, the prebiotic effect of 1-kestose supplementation on fasting insulin concentration in obesity-prone humans and rats was investigated, and it was shown that 1-Kestose supplements may potentially ameliorate insulin resistance in overweight humans via modulation of the gut microbiota.
References
More filters
Journal ArticleDOI
Diet rapidly and reproducibly alters the human gut microbiome
Lawrence A. David,Corinne F. Maurice,Rachel N. Carmody,David B. Gootenberg,Julie E. Button,Benjamin E. Wolfe,Alisha V. Ling,A. Sloan Devlin,Yug Varma,Michael A. Fischbach,Sudha B. Biddinger,Rachel J. Dutton,Peter J. Turnbaugh +12 more
TL;DR: Increases in the abundance and activity of Bilophila wadsworthia on the animal-based diet support a link between dietary fat, bile acids and the outgrowth of microorganisms capable of triggering inflammatory bowel disease.
Journal ArticleDOI
Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic
Colin Hill,Francisco Guarner,Gregor Reid,Glenn R. Gibson,Daniel Merenstein,Bruno Pot,Lorenzo Morelli,Roberto Berni Canani,Harry J. Flint,Seppo Salminen,Philip C. Calder,Mary Ellen Sanders +11 more
TL;DR: An expert panel was convened in October 2013 by the International Scientific Association for Probiotics and Prebiotics (ISAPP) to discuss the field of probiotics and the appropriate use and scope of the term probiotic.
Journal ArticleDOI
A metagenome-wide association study of gut microbiota in type 2 diabetes
Junjie Qin,Yingrui Li,Zhiming Cai,Shenghui Li,Jianfeng Zhu,Fan Zhang,Suisha Liang,Wenwei Zhang,Yuanlin Guan,Dongqian Shen,Yangqing Peng,Dongya Zhang,Zhuye Jie,Wenxian Wu,Youwen Qin,Wenbin Xue,Junhua Li,Lingchuan Han,Donghui Lu,Peixian Wu,Yali Dai,Xiaojuan Sun,Zesong Li,Aifa Tang,Shilong Zhong,Xiaoping Li,Weineng Chen,Ran Xu,Mingbang Wang,Qiang Feng,Meihua Gong,Jing Yu,Yanyan Zhang,Ming Zhang,Torben Hansen,Gaston Sanchez,Jeroen Raes,Gwen Falony,Shujiro Okuda,Mathieu Almeida,Emmanuelle Le-chatelier,Pierre Renault,Nicolas Pons,Jean-Michel Batto,Zhaoxi Zhang,Hua Chen,Ruifu Yang,Wei-Mou Zheng,Songgang Li,Huanming Yang,Jian Wang,S. Dusko Ehrlich,Rasmus Nielsen,Oluf Pedersen,Oluf Pedersen,Karsten Kristiansen,Jun Wang +56 more
TL;DR: MGWAS analysis showed that patients with type 2 diabetes were characterized by a moderate degree of gut microbial dysbiosis, a decrease in the abundance of some universal butyrate-producing bacteria and an increase in various opportunistic pathogens, as well as an enrichment of other microbial functions conferring sulphate reduction and oxidative stress resistance.
Journal ArticleDOI
Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition.
Pouya Saeedi,Inga Petersohn,Paraskevi Salpea,Belma Malanda,Suvi Karuranga,Nigel Unwin,Stephen Colagiuri,Leonor Guariguata,Ayesha A. Motala,Katherine Ogurtsova,Jonathan E. Shaw,Dominic Bright,Rhys Williams +12 more
TL;DR: Just under half a billion people are living with diabetes worldwide and the number is projected to increase by 25% in 2030 and 51% in 2045, with the prevalence higher in urban than rural areas, and in high-income than low-income countries.
Journal ArticleDOI
Mechanisms linking obesity to insulin resistance and type 2 diabetes
TL;DR: In obese individuals, adipose tissue releases increased amounts of non-esterified fatty acids, glycerol, hormones, pro-inflammatory cytokines and other factors that are involved in the development of insulin resistance.
Related Papers (5)
Intestinal microbiota and type 2 diabetes: from mechanism insights to therapeutic perspective.
Jun-Ling Han,Hui-Ling Lin +1 more