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Open AccessJournal ArticleDOI

The role of the gut microbiome in chronic liver disease: the clinical evidence revised.

Katherine J. P. Schwenger, +4 more
- Vol. 1, Iss: 3, pp 214-226
TLDR
The relationship between the intestinal microbiota and liver diseases is discussed, as well as reviewing intestinal microbiota-based treatment options that are currently being investigated, and there is emerging evidence on the effects of faecal microbial transplant.
Abstract: 
Recent research has suggested a role for the intestinal microbiota in the pathogenesis and potential treatment of a wide range of liver diseases. The intestinal microbiota and bacterial products may contribute to the development of liver diseases through multiple mechanisms including increased intestinal permeability, chronic systemic inflammation, production of short-chain fatty acids and changes in metabolism. This suggests a potential role for pre-, pro- and synbiotic products in the prevention or treatment of some liver diseases. In addition, there is emerging evidence on the effects of faecal microbial transplant. Herein, we discuss the relationship between the intestinal microbiota and liver diseases, as well as reviewing intestinal microbiota-based treatment options that are currently being investigated.

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Citations
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Journal ArticleDOI

Gut microbiota in human metabolic health and disease.

Yong Fan, +1 more
- 01 Jan 2021 - 
TL;DR: How the gut microbiota and derived microbial compounds may contribute to human metabolic health and to the pathogenesis of common metabolic diseases are discussed, and examples of microbiota-targeted interventions aiming to optimize metabolic health are highlighted.
Journal ArticleDOI

Contribution of the Intestinal Microbiome and Gut Barrier to Hepatic Disorders

Daniel M. Chopyk, +2 more
- 01 Sep 2020 - 
TL;DR: The mechanisms that regulate intestinal permeability are reviewed and how changes in the intestinal microbiome contribute to development of acute and chronic liver diseases are discussed.
Journal ArticleDOI

Nutritional Components in Western Diet Versus Mediterranean Diet at the Gut Microbiota-Immune System Interplay. Implications for Health and Disease.

Cielo García-Montero, +23 more
- 22 Feb 2021 - 
TL;DR: In this article, the regulatory role of nutritional components of WD and MD in the gut microbiota and immune system interplay, in order to understand, and create awareness of, the influence of diet over both key components.
Journal ArticleDOI

Microbiota and Fatty Liver Disease-the Known, the Unknown, and the Future.

Sonja Lang, +2 more
- 12 Aug 2020 - 
TL;DR: How microbes and their products contribute to liver disease pathogenesis, putative microbial biomarkers of disease, and potential treatment approaches based on manipulation of the gut microbiota are discussed.
Journal ArticleDOI

Chronic Inflammation in Non-Alcoholic Steatohepatitis: Molecular Mechanisms and Therapeutic Strategies

Carmelo Luci, +4 more
- 14 Dec 2020 - 
TL;DR: The processes triggering the recruitment and/or activation of hepatic innate immune cells, with a focus on macrophages, neutrophils, and innate lymphoid cells as well as the contribution of hepatocytes and endothelial cells in driving liver inflammation/fibrosis are highlighted.
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