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Journal ArticleDOI

Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production

Jorge Alonso-Gutierrez, +11 more
- 01 Sep 2013 - 
- Vol. 19, pp 33-41
TLDR
A strain containing all mevalonate pathway genes in a single plasmid produced limonene at titers over 400mg/L from glucose, substantially higher than has been achieved in the past.
About: 
This article is published in Metabolic Engineering.The article was published on 2013-09-01. It has received 328 citations till now. The article focuses on the topics: Perillyl alcohol & Limonene.

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Citations
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Journal ArticleDOI

Advances in the Metabolic Engineering of Escherichia coli for the Manufacture of Monoterpenes

Si-si Xie, +4 more
- 09 May 2019 - 
TL;DR: This review discusses the endogenous methylerythritol-4-phosphate- dependent pathway engineering and the exogenous mevalonate-dependent isoprenoid pathway introduction, as well as the accompanied optimization of rate-limiting enzymes, metabolic flux, and product toxicity tolerance.
Journal ArticleDOI

Structural diversity and biosynthesis of plant derived p -menthane monoterpenes

Matthew E. Bergman, +1 more
- 01 Apr 2021 - 
TL;DR: This review examines the chemical diversity of the p-menthanes in the plant kingdom, their biosynthetic origins in specialized anatomical structures, and the enzymology of p-MENThane biosynthesis enzymes from diverse plant families.
Journal ArticleDOI

Genome-wide screening identifies promiscuous phosphatases impairing terpenoid biosynthesis in Escherichia coli

Tianmin Wang, +5 more
- 18 Sep 2018 - 
TL;DR: The necessity of reconsidering the interactions of promiscuous phosphatases with ubiquitous phosphorylated components of metabolic networks with respect to engineering metabolism is suggested.
Journal ArticleDOI

Metabolic engineering of microbes for monoterpenoid production

Kun Zhu, +11 more
- 20 Sep 2021 - 
TL;DR: In this paper, the authors review the recent advances in engineering microbes for monoterpenoid production, with an emphasis on categorized strategies, and discuss the challenges and perspectives to offer guidance for future engineering.
Journal ArticleDOI

Metabolic engineering of Escherichia coli to high efficient synthesis phenylacetic acid from phenylalanine.

Lihua Zhang, +4 more
- 25 May 2017 - 
TL;DR: The results reveal the high efficiency of the RARE strain for production of PAA and indicate the potential industrial applicability of this microbial platform for PAA biosynthesis.
References
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Journal ArticleDOI

Studies on transformation of Escherichia coli with plasmids

Douglas Hanahan, +1 more
- 05 Jun 1983 - 
TL;DR: Competition with both transforming and non-transforming plasmids indicates that each cell is capable of taking up many DNA molecules, and that the establishment of a transformation event is neither helped nor hindered significantly by the presence of multiple plasmid molecules.
Journal ArticleDOI

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

Brendan MacLean, +9 more
- 01 Apr 2010 - 
TL;DR: The Skyline user interface simplifies the development of mass spectrometer methods and the analysis of data from targeted proteomics experiments performed using selected reaction monitoring (SRM).
Journal ArticleDOI

Production of the antimalarial drug precursor artemisinic acid in engineered yeast

Dae-Kyun Ro, +14 more
- 13 Apr 2006 - 
TL;DR: The engineering of Saccharomyces cerevisiae to produce high titres (up to 100 mg l-1) of artemisinic acid using an engineered mevalonate pathway, amorphadiene synthase, and a novel cytochrome P450 monooxygenase from A. annua that performs a three-step oxidation of amorpha-4,11-diene to art Artemisinic acid.
Journal ArticleDOI

Analysis of gene control signals by DNA fusion and cloning in Escherichia coli

Malcolm J. Casadaban, +1 more
- 05 Apr 1980 - 
TL;DR: Plasmid cloning vectors that enable insertion of DNA fragments between the inducible ara (arabinose) promoter and the lac (lactose) structural genes have been constructed and used for the detection and analysis of signals that control gene transcription.
Journal ArticleDOI

Engineering a mevalonate pathway in Escherichia coli for production of terpenoids

Vincent J. J. Martin, +4 more
- 01 Jul 2003 - 
TL;DR: The strains developed in this study can serve as platform hosts for the production of any terpenoid compound for which a terpene synthase gene is available, and are the universal precursors to all isoprenoids.
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Trending Questions (1)
What is use the of metabolic engineering? limonene?

Metabolic engineering is used to produce limonene, a valuable monoterpene used in the production of commodity chemicals and medicinal compounds.

See answers from 4 other papers