Journal ArticleDOI
Metastasis promoter S100A4 is a potentially valuable molecular target for cancer therapy.
TLDR
By virtue of its ability to activate interacting and multi-functional signalling systems, S100A4 appears to offer suitable targets for developing new therapeutic procedures and might also lend themselves as foci of therapeutic interest.About:
This article is published in Cancer Letters.The article was published on 2009-07-18. It has received 100 citations till now. The article focuses on the topics: Cancer & Metastasis.read more
Citations
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Hypoxic Tumor Cell Modulates Its Microenvironment to Enhance Angiogenic and Metastatic Potential by Secretion of Proteins and Exosomes
Jung Eun Park,Hon Sen Tan,Arnab Datta,Ruenn Chai Lai,Huoming Zhang,Wei Meng,Sai Kiang Lim,Siu Kwan Sze +7 more
TL;DR: In this article, the authors observed that tumor cells produce a secretion that modifies their microenvironment to facilitate tumor angiogenesis and metastasis under hypoxia, and the secreted proteins were predominantly cytoplasmic and membrane proteins.
Journal ArticleDOI
Activation of fibroblasts in cancer stroma.
Kati Räsänen,Antti Vaheri +1 more
TL;DR: This review focuses mainly on carcinomas and discusses the recent findings regarding the role of activated fibroblasts in driving tumor progression.
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Biological responses in stented arteries
TL;DR: It is noteworthy that animals show a rapid progression of healing after stent deployment compared with man, and drugs like rapamycin and paclitaxel have been coated on stent with polymers to allow local slow release of drugs, which have resulted in dramatic reduction of restenosis that was once the Achilles' heel of interventional cardiologists.
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N-myc downstream regulated gene 1 modulates Wnt-β-catenin signalling and pleiotropically suppresses metastasis.
Wen Liu,Fei Xing,Megumi Iiizumi-Gairani,Hiroshi Okuda,Misako Watabe,Sudha K. Pai,Puspa R. Pandey,Shigeru Hirota,Aya Kobayashi,Yin-Yuan Mo,Koji Fukuda,Yi Li,Kounosuke Watabe +12 more
TL;DR: NDRG1 is identified as a novel negative master regulator of Wnt signalling during the metastatic progression, which opens an opportunity to define a potential therapeutic target for metastatic disease.
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Novel Effect of Antihelminthic Niclosamide on S100A4-Mediated Metastatic Progression in Colon Cancer
Ulrike Sack,Wolfgang Walther,Dominic A. Scudiero,Mike Selby,Dennis Kobelt,Margit Lemm,Iduna Fichtner,Peter M. Schlag,Robert H. Shoemaker,Ulrike Stein +9 more
TL;DR: Niclosamide inhibits S100A4-induced metastasis formation in a mouse model of colon cancer and has therapeutic potential.
References
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Journal ArticleDOI
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
TL;DR: 21-nucleotide siRNA duplexes provide a new tool for studying gene function in mammalian cells and may eventually be used as gene-specific therapeutics.
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Role for a bidentate ribonuclease in the initiation step of RNA interference
TL;DR: Dicer is a member of the RNase III family of nucleases that specifically cleave double-stranded RNAs, and is evolutionarily conserved in worms, flies, plants, fungi and mammals, and has a distinctive structure, which includes a helicase domain and dualRNase III motifs.
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The Wnt signaling pathway in development and disease.
Catriona Y. Logan,Roel Nusse +1 more
TL;DR: The data reveal that multiple extracellular, cytoplasmic, and nuclear regulators intricately modulate Wnt signaling levels, and that receptor-ligand specificity and feedback loops help to determine WNT signaling outputs.
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A species of small antisense RNA in posttranscriptional gene silencing in plants.
TL;DR: The 25-nucleotide antisense RNA detected in transgene-induced PTGS is likely synthesized from an RNA template and may represent the specificity determinant of PTGS.
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VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Holger Gerhardt,Matthew Golding,Marcus Fruttiger,Christiana Ruhrberg,Andrea Lundkvist,Alexandra Abramsson,Michael Jeltsch,Christopher A. Mitchell,Kari Alitalo,David T. Shima,Christer Betsholtz +10 more
TL;DR: It is shown here that VEGF-A controls angiogenic sprouting in the early postnatal retina by guiding filopodial extension from specialized endothelial cells situated at the tips of the vascular sprouts.