Journal ArticleDOI
Natural helper cells contribute to pulmonary eosinophilia by producing IL-13 via IL-33/ST2 pathway in a murine model of respiratory syncytial virus infection
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TLDR
Results demonstrate that natural helper cells may play an important role in RSV-induced pulmonary eosinophilia by producing IL-13 via the IL-33/ST2 pathway.About:
This article is published in International Immunopharmacology.The article was published on 2015-09-01. It has received 29 citations till now. The article focuses on the topics: Interleukin 13 & Innate lymphoid cell.read more
Citations
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Journal ArticleDOI
Sex Hormones Regulate Innate Immune Cells and Promote Sex Differences in Respiratory Virus Infection
TL;DR: The literature on sex differences and sex hormone regulation in innate immune cells in the lung in homeostasis and upon respiratory virus infection is reviewed.
Journal ArticleDOI
Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease.
TL;DR: There is intensive investigation into the role of ILC2s in human disease with the hope of a better understanding of the pathophysiology and the discovery of novel potential therapeutic targets.
Journal ArticleDOI
Neonatal Immunity, Respiratory Virus Infections, and the Development of Asthma
TL;DR: The differences between the neonatal and adult immune systems are outlined and murine and human data are presented that support the hypothesis that early-life interactions between the immune system and respiratory viruses can create a lung environment conducive to the development of asthma.
Journal ArticleDOI
Altered Treg and cytokine responses in RSV-infected infants.
Allison F. Christiaansen,Muhammad Ali Syed,Patrick Ten Eyck,Stacey M. Hartwig,Lakshmi Durairaj,Sameer S. Kamath,Steven M. Varga +6 more
TL;DR: Surprisingly, T helper (Th)17 related cytokines including interleukin (IL)-1β, IL-17A, and IL-23 were associated with a reduction in clinical symptoms of respiratory distress and the amount of IL-33 protein in nasal washes was decreased in RSV-infected children.
Journal ArticleDOI
Are ILC2s Jekyll and Hyde in airway inflammation
TL;DR: Accumulating evidence on the heterogeneity, plasticity, regulatory mechanisms, and pleiotropic roles of ILC2s in allergic inflammation as well as mechanisms for their suppression in the airways are summarized.
References
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Journal ArticleDOI
A simple method of estimating fifty per cent endpoints
Lowell J. Reed,H. Muench +1 more
Journal ArticleDOI
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
Jochen Schmitz,Alexander Owyang,Elizabeth R. Oldham,Yaoli Song,Erin Murphy,Terril K. McClanahan,Gerard Zurawski,Mehrdad M. Moshrefi,Jinzhong Qin,Xiaoxia Li,Daniel M. Gorman,J. Fernando Bazan,Robert A. Kastelein +12 more
TL;DR: A member of theIL-1 family, IL-33, which mediates its biological effects via IL-1 receptor ST 2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitro polarized T( H)2 cells is reported.
Journal ArticleDOI
Innate lymphoid cells--a proposal for uniform nomenclature.
Hergen Spits,David Artis,Marco Colonna,Andreas Diefenbach,James P. Di Santo,Gérard Eberl,Shigeo Koyasu,Richard M. Locksley,Andrew N.J. McKenzie,Reina E. Mebius,Fiona Powrie,Eric Vivier,Eric Vivier +12 more
TL;DR: It is proposed that ILCs should be categorized into three groups based on the cytokines that they can produce and the transcription factors that regulate their development and function.
Journal ArticleDOI
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
Daniel R. Neill,See Heng Wong,Agustin Bellosi,Robin J. Flynn,Maria Daly,Theresa K. A. Langford,Christine Bucks,Colleen M. Kane,Padraic G. Fallon,Richard Pannell,Helen E. Jolin,Andrew N.J. McKenzie +11 more
TL;DR: The identification and functional characterization of a new innate type-2 immune effector leukocyte that is named the nuocyte is presented, which represents a critically important innate effector cell in type- 2 immunity.
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Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
Laurel A. Monticelli,Gregory F. Sonnenberg,Michael C. Abt,Theresa Alenghat,Carly G. K. Ziegler,Travis A. Doering,Jill M. Angelosanto,Brian J. Laidlaw,Cliff Y Yang,Taheri Sathaliyawala,Masaru Kubota,Damian Turner,Joshua M. Diamond,Ananda W. Goldrath,Donna L. Farber,Ronald G. Collman,E. John Wherry,David Artis +17 more