New insights into the classification and nomenclature of cortical GABAergic interneurons
Javier DeFelipe,Pedro L. López-Cruz,Ruth Benavides-Piccione,Ruth Benavides-Piccione,Concha Bielza,Pedro Larrañaga,Stewart A. Anderson,Andreas Burkhalter,Bruno Cauli,Alfonso Fairén,Dirk Feldmeyer,Gord Fishell,David Fitzpatrick,Tamás F. Freund,Guillermo Gonzalez-Burgos,Shaul Hestrin,Sean Hill,Patrick R. Hof,Josh Huang,Edward G. Jones,Yasuo Kawaguchi,Zoltán F. Kisvárday,Yoshiyuki Kubota,David A. Lewis,Oscar Marín,Henry Markram,Chris J. McBain,Hanno S. Meyer,Hannah Monyer,Sacha B. Nelson,Kathleen S. Rockland,Jean Rossier,John L.R. Rubenstein,Bernardo Rudy,Massimo Scanziani,Gordon M. Shepherd,Chet C. Sherwood,Jochen F. Staiger,Gábor Tamás,Alex M. Thomson,Yun Wang,Yun Wang,Rafael Yuste,Giorgio A. Ascoli +43 more
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TLDR
A possible taxonomical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web-based interactive system that allows experts to classify neurons with pre-determined criteria is described.Abstract:
A systematic classification and accepted nomenclature of neuron types is much needed but is currently lacking. This article describes a possible taxonomical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web-based interactive system that allows experts to classify neurons with pre-determined criteria. Using Bayesian analysis and clustering algorithms on the resulting data, we investigated the suitability of several anatomical terms and neuron names for cortical GABAergic interneurons. Moreover, we show that supervised classification models could automatically categorize interneurons in agreement with experts' assignments. These results demonstrate a practical and objective approach to the naming, characterization and classification of neurons based on community consensus.read more
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Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
Amit Zeisel,Ana B. Muñoz-Manchado,Simone Codeluppi,Peter Lönnerberg,Gioele La Manno,Anna Juréus,Sueli Marques,Hermany Munguba,Liqun He,Christer Betsholtz,Christer Betsholtz,Charlotte Rolny,Gonçalo Castelo-Branco,Jens Hjerling-Leffler,Sten Linnarsson +14 more
TL;DR: Large-scale single-cell RNA sequencing is used to classify cells in the mouse somatosensory cortex and hippocampal CA1 region and found 47 molecularly distinct subclasses, comprising all known major cell types in the cortex.
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Adult mouse cortical cell taxonomy revealed by single cell transcriptomics
Bosiljka Tasic,Vilas Menon,Thuc Nghi Nguyen,Tae Kyung Kim,Tim Jarsky,Zizhen Yao,Boaz P. Levi,Lucas T. Gray,Staci A. Sorensen,Tim A. Dolbeare,Darren Bertagnolli,Jeff Goldy,Nadiya V. Shapovalova,Sheana Parry,Changkyu Lee,Kimberly A. Smith,Amy Bernard,Linda Madisen,Susan M. Sunkin,Michael Hawrylycz,Christof Koch,Hongkui Zeng +21 more
TL;DR: This work constructed a cellular taxonomy of one cortical region, primary visual cortex, in adult mice on the basis of single-cell RNA sequencing and identified 49 transcriptomic cell types, including 23 GABAergic, 19 glutamatergic and 7 non-neuronal types.
Journal ArticleDOI
GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits
TL;DR: Current understanding of neocortical interneuron diversity and the properties that distinguish cell types are reviewed and it is illustrated how recent advances in the field have shed light onto the mechanisms by which GABAergic inhibition contributes to network operations.
Journal ArticleDOI
Reconstruction and Simulation of Neocortical Microcircuitry
Henry Markram,Henry Markram,Eilif Muller,Srikanth Ramaswamy,Michael W. Reimann,Marwan Abdellah,Carlos Aguado Sanchez,Anastasia Ailamaki,Lidia Alonso-Nanclares,Lidia Alonso-Nanclares,Nicolas Antille,Selim Arsever,Guy Antoine Atenekeng Kahou,Thomas K. Berger,Ahmet Bilgili,Nenad Buncic,Athanassia Chalimourda,Giuseppe Chindemi,Jean Denis Courcol,Fabien Delalondre,Vincent Delattre,Shaul Druckmann,Shaul Druckmann,Raphael Dumusc,James Dynes,Stefan Eilemann,Eyal Gal,Michael Gevaert,Jean Pierre Ghobril,Albert Gidon,Joe W. Graham,Anirudh Gupta,Valentin Haenel,Etay Hay,Thomas Heinis,Thomas Heinis,Juan Hernando,Michael L. Hines,Lida Kanari,Daniel Keller,John Kenyon,Georges Khazen,Yihwa Kim,James G. King,Zoltán F. Kisvárday,Pramod Kumbhar,Sebastien Lasserre,Jean Vincent Le Bé,Bruno R. C. Magalhães,Angel Merchán-Pérez,Angel Merchán-Pérez,Julie Meystre,Benjamin Roy Morrice,Jeffrey Muller,Alberto Muñoz-Céspedes,Alberto Muñoz-Céspedes,Shruti Muralidhar,Keerthan Muthurasa,Daniel Nachbaur,Taylor Howard Newton,Max Nolte,Aleksandr Ovcharenko,Juan Palacios,Luis Pastor,Rodrigo Perin,Rajnish Ranjan,Rajnish Ranjan,Imad Riachi,José-Rodrigo Rodríguez,José-Rodrigo Rodríguez,Juan Luis Riquelme,Christian Rössert,Konstantinos Sfyrakis,Ying Shi,Ying Shi,Julian C. Shillcock,Gilad Silberberg,Ricardo Silva,Farhan Tauheed,Martin Telefont,Maria Toledo-Rodriguez,Thomas Tränkler,Werner Van Geit,Jafet Villafranca Diaz,Richard Walker,Yun Wang,Yun Wang,Stefano M. Zaninetta,Javier DeFelipe,Javier DeFelipe,Sean Hill,Idan Segev,Felix Schürmann +92 more
TL;DR: A first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat is presented, finding a spectrum of network states with a sharp transition from synchronous to asynchronous activity, modulated by physiological mechanisms.
Journal ArticleDOI
Inhibition of Inhibition in Visual Cortex: The Logic of Connections Between Molecularly Distinct Interneurons
TL;DR: This work describes a simple and complementary interaction scheme between three large, molecularly distinct interneuron populations in mouse visual cortex: parvalbumin-expressing interneurons strongly inhibit one another but provide little inhibition to other populations, while somatostatin-expresses avoid inhibiting one another yet strongly inhibit all other populations.
References
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Journal ArticleDOI
Statistical pattern recognition: a review
TL;DR: The objective of this review paper is to summarize and compare some of the well-known methods used in various stages of a pattern recognition system and identify research topics and applications which are at the forefront of this exciting and challenging field.
Journal ArticleDOI
Statistical Pattern Recognition
TL;DR: In this paper, the primary goal of pattern recognition is supervised or unsupervised classification, and the various frameworks in which pattern recognition has been traditionally formulated, the statistical approach has been used.
Journal ArticleDOI
Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex
Giorgio A. Ascoli,Lidia Alonso-Nanclares,Stewart A. Anderson,German Barrionuevo,Ruth Benavides-Piccione,Andreas Burkhalter,György Buzsáki,Bruno Cauli,Javier DeFelipe,Alfonso Fairén,Dirk Feldmeyer,Gord Fishell,Yves Frégnac,Tamás F. Freund,Daniel Gardner,Esther P. Gardner,Jesse H. Goldberg,Moritz Helmstaedter,Shaul Hestrin,Fuyuki Karube,Zoltán F. Kisvárday,Bertrand Lambolez,David A. Lewis,Oscar Marín,Henry Markram,Alberto Muñoz,Adam M. Packer,Carl C.H. Petersen,Kathleen S. Rockland,Jean Rossier,Bernardo Rudy,Peter Somogyi,Jochen F. Staiger,Gábor Tamás,Alex M. Thomson,Maria Toledo-Rodriguez,Yun Wang,David C. West,Rafael Yuste +38 more
TL;DR: A representative group of researchers are convened to agree on a set of terms to describe the anatomical, physiological and molecular features of GABAergic interneurons of the cerebral cortex, and the resulting terminology might provide a stepping stone towards a future classification of these complex and heterogeneous cells.
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