Nucleocytoplasmic O-glycosylation in protists
Christopher M. West,Hyun W. Kim +1 more
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TLDR
Cellular roles of nucleocytoplasmic glycans are interpreted in terms of current evidence for their effects on the conformation and dynamics of protist proteins, to serve as a guide for future studies to examine their broader significance.About:
This article is published in Current Opinion in Structural Biology.The article was published on 2019-05-22 and is currently open access. It has received 13 citations till now. The article focuses on the topics: Glycosylation.read more
Citations
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Journal ArticleDOI
Demystifying the O-GlcNAc Code: A Systems View.
Junfeng Ma,Chunyan Hou,Ci Wu +2 more
TL;DR: A comprehensive survey of O-GlcNAcylation in multiple species studied, including eukaryotes, fungi, plants, Caenorhabditis elegans, Drosophila melanogaster, murine, and human, and some viruses is provided.
Journal ArticleDOI
Comprehensive O-Glycosylation Analysis of the SARS-CoV-2 Spike Protein with Biomimetic Trp-Arg Materials.
TL;DR: In this paper, the authors designed a biomimetic materials, Trp-Arg (WR) monomer-grafted silica microspheres (designated as WR-SiO2), which can enrich N- and O-linked glycopeptides with high selectivity.
Journal ArticleDOI
Skp1 Dimerization Conceals Its F-Box Protein Binding Site
Hyun W. Kim,Alexander Eletsky,Karen J. Gonzalez,Hanke van der Wel,Eva-Maria Strauch,James H. Prestegard,Christopher M. West +6 more
TL;DR: A nearly full-length version of Skp1 with the F97E substitution behaved as a stable monomer at concentrations up to 500 µM and actively bound a model FBP, mammalian Fbs1, which suggests that the dimeric state is not required forSkp1 to carry out a basic biochemical function.
Journal ArticleDOI
Skp1 isoforms are differentially modified by a dual function prolyl 4-hydroxylase/N-acety lglucosaminyltransferase in a plant pathogen
TL;DR: Findings indicate a widespread occurrence of theSkp1 modification pathway across protist phylogeny, suggest that both Gnt1 and PhyA are specific for Skp1, and indicate that the second Skp 1 provides a bypass mechanism for O2-regulation in Pythium and other protists that conserve this gene.
Journal Article
Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast
Adnan Halim,Ida Signe Bohse Larsen,Patrick Neubert,Hiren J. Joshi,Bent O. Petersen,Sergey Y. Vakhrushev,Sabine Strahl,Henrik Clausen +7 more
TL;DR: Yeast use O-linked mannose to modify nucleocytoplasmic proteins on evolutionary-conserved regions and sites normally occupied by O-GlcNAc in higher eukaryotes, revealing that the two different types of O-glycosylations serve the same important biological functions.
References
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The Top 10 oomycete pathogens in molecular plant pathology
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TL;DR: A survey to query the community for their ranking of plant-pathogenic oomycete species based on scientific and economic importance received 263 votes from 62 scientists in 15 countries for a total of 33 species and the Top 10 species are provided.
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Systematic Functional Prioritization of Protein Posttranslational Modifications
Pedro Beltrao,Pedro Beltrao,Véronique Albanèse,Lillian R. Kenner,Lillian R. Kenner,Danielle L. Swaney,Alma L. Burlingame,Alma L. Burlingame,Judit Villén,Wendell A. Lim,Wendell A. Lim,James S. Fraser,James S. Fraser,Judith Frydman,Nevan J. Krogan,Nevan J. Krogan +15 more
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The Extracellular Architecture of Adherens Junctions Revealed by Crystal Structures of Type I Cadherins
O.J. Harrison,Xiangshu Jin,Soonjin Hong,Fabiana Bahna,Goran Ahlsen,Julia Brasch,Yinghao Wu,Jeremie Vendome,Klara Felsovalyi,Cheri M. Hampton,Regina B. Troyanovsky,Avinoam Ben-Shaul,Joachim Frank,Sergey M. Troyanovsky,Lawrence Shapiro,Barry Honig +15 more
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2-Oxoglutarate-Dependent Oxygenases
Md. Saiful Islam,Thomas M. Leissing,Rasheduzzaman Chowdhury,Richard J. Hopkinson,Richard J. Hopkinson,Christopher J. Schofield +5 more
TL;DR: An overview of the biochemistry of 2OGXs is given, providing examples linking to biological function, and how knowledge of their enzymology is being exploited in medicine, agrochemistry, and biocatalysis is outlined.