Journal ArticleDOI
Platelet Biogenesis in the Lung Circulation
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TLDR
It is concluded that the lung has significant hematopoietic potential including being a major site of platelet biogenesis and orthotopic, single-lung transplantation experiments into thrombocytopenic and hematOPoietIC progenitor-deficient animals revealed that peripheral blood platelet counts and bone marrow hematopolietic progenitors could be fully reconstituted by the lung transplant procedure.About:
This article is published in Blood.The article was published on 2018-11-21. It has received 29 citations till now. The article focuses on the topics: Thrombopoietin & Megakaryocyte.read more
Citations
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Platelets are highly efficient and efficacious carriers for tumor-targeted nano-drug delivery
Qi-Rui Li,Hua-Zhen Xu,Rong-Cheng Xiao,Yang Liu,Jun-Ming Tang,Jian Li,Tingting Yu,Bin Liu,Liu-Gen Li,Mei Fang Wang,Ning Han,Yong-Hong Xu,Chao Wang,Naoki Komatsu,Li Zhao,Xingchun Peng,Tong Liu,Xiao Liang Chen +17 more
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Journal ArticleDOI
Advances in research on the effects of platelet activation in acute lung injury (Review)
TL;DR: Evidence is provided to support the importance of the consideration of platelets in the search for ALI interventional targets, with the latest research progress on secretion of bioactive mediators from platelets, platelet activation-related signaling pathways, and the direct contact reactions between platelets and neutrophils with endothelial cells that result in ALI described.
Journal ArticleDOI
Rasa3 deficiency minimally affects thrombopoiesis but promotes severe thrombocytopenia due to integrin-dependent platelet clearance
Robert H. Lee,Dorsaf Ghalloussi,Gabriel Harousseau,Joseph P Kenny,Patrick A Kramer,Fabienne Proamer,Bernhard Nieswandt,Matthew J. Flick,Christian Gachet,Caterina Casari,Anita Eckly,Wolfgang Bergmeier +11 more
TL;DR: A potentially novel, integrin-based mechanism of platelet clearance that could be critical for the understanding of select inherited and acquired thrombocytopenias is described.
Journal ArticleDOI
Platelets, Bacterial Adhesins and the Pneumococcus
TL;DR: The bacteria-platelet interplay in the context of adhesin–receptor interactions and platelet-activating bacterial proteins is discussed, with a main emphasis on S. aureus and S. pneumoniae.
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Factors Associated with Platelet Activation-Recent Pharmaceutical Approaches
Panagiotis Theofilis,Marios Sagris,Evangelos Oikonomou,Alexios S. Antonopoulos,Constantinos Tsioufis,Dimitris Tousoulis +5 more
TL;DR: An overview of the available antiplatelet agents is being portrayed, together with agents possessing off-set platelet-inhibitory actions, while an extensive presentation of drugs under investigation is given.
References
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Journal ArticleDOI
Decoding Human Megakaryocyte Development.
Hongtao Wang,Jian He,Changlu Xu,Xiaoyuan Chen,Hua Yang,Shujuan Shi,Cuicui Liu,Yang Zeng,Dan Wu,Zhijie Bai,Mengge Wang,Yuqi Wen,Pei Su,Meijuan Xia,Baiming Huang,Chunyu Ma,Lihong Bian,Yu Lan,Tao Cheng,Lihong Shi,Bing Liu,Jiaxi Zhou +21 more
TL;DR: Single-cell RNA sequencing of human MKs from embryonic yolk sac and fetal liver is used to characterize the transcriptome, cellular heterogeneity, and developmental trajectories of early megakaryopoiesis and identifies a subpopulation of CD42b+CD14+ MKs in vivo that exhibit high expression of genes associated with immune responses.
Journal ArticleDOI
Platelet aggregates, a marker of severe COVID-19 disease.
Alexandros Rampotas,Sue Pavord +1 more
TL;DR: The presence of platelet aggregates and macrothrombocytes indicating increased platelet activity could be consistent with severe COVID-19 infection and is further evidence of the important role that platelets play when CO VID-19 manifests with thrombotic complications or respiratory failure.
Journal ArticleDOI
Lung megakaryocytes display distinct transcriptional and phenotypic properties.
Anthony K. Yeung,Carlos Villacorta-Martin,Stephanie Hon,Stephanie Hon,Jason R. Rock,Jason R. Rock,George J. Murphy +6 more
TL;DR: Findings support the notion that the lung plays an independent role in the development and functional maturation of MKs, and highlight the existence of a lung-specific MK phenotype that is skewed toward roles in immunity and inflammation.
Journal ArticleDOI
Pulmonary Megakaryocytes in Coronavirus Disease 2019 (COVID-19): Roles in Thrombi and Fibrosis
Jecko Thachil,Ton Lisman +1 more
TL;DR: Este es el reporte de situación COVID-19 Colombia No 130 - 27 de agosto de 2020.
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Lung as a Niche for Hematopoietic Progenitors
Isabella T. Borges,Isadora F. G. Sena,Patrick O. Azevedo,Julia P. Andreotti,Viviani M. Almeida,Ana Luiza Bittencourt Paiva,Gabryella S P Santos,Daniel A. P. Guerra,Pedro H.D.M. Prazeres,Luiza Lousado Mesquita,Luanny Souto de Barros Silva,Caroline Leonel,Akiva Mintz,Alexander Birbrair,Alexander Birbrair +14 more