Presynaptic Partners of Dorsal Raphe Serotonergic and GABAergic Neurons
Brandon Weissbourd,Jing Ren,Katherine E. DeLoach,Casey J. Guenthner,Kazunari Miyamichi,Liqun Luo,Liqun Luo +6 more
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TLDR
Using viral tracing combined with electrophysiology, it is found that GABA and serotonin neurons in the DR receive excitatory, inhibitory, and peptidergic inputs from the same specific brain regions.About:
This article is published in Neuron.The article was published on 2014-08-06 and is currently open access. It has received 273 citations till now. The article focuses on the topics: Serotonergic & GABAergic.read more
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Journal ArticleDOI
Circuit Architecture of VTA Dopamine Neurons Revealed by Systematic Input-Output Mapping.
Kevin T. Beier,Elizabeth E. Steinberg,Katherine E. DeLoach,Stanley Xie,Kazunari Miyamichi,Lindsay A. Schwarz,Xiaojing J. Gao,Eric J. Kremer,Robert C. Malenka,Liqun Luo +9 more
TL;DR: The utility of viral-genetic tracing strategies to elucidate the complex neural substrates that underlie motivated behaviors is highlighted, including a previously unappreciated top-down reinforcing circuit from anterior cortex to lateral nucleus accumbens via VTA-DA neurons.
Journal ArticleDOI
Neural Circuitry of Wakefulness and Sleep
TL;DR: Key models for the regulation of rapid eye movement sleep and non-REM sleep are outlined, how mutual inhibition between specific pathways gives rise to these distinct states, and how dysfunction in these circuits can give rise to sleep disorders.
Journal ArticleDOI
Viral-genetic tracing of the input–output organization of a central noradrenaline circuit
Lindsay A. Schwarz,Kazunari Miyamichi,Xiaojing J. Gao,Kevin T. Beier,Brandon Weissbourd,Katherine E. DeLoach,Jing Ren,Sandy Ibanes,Robert C. Malenka,Eric J. Kremer,Liqun Luo +10 more
TL;DR: A set of viral-genetic tools to quantitatively analyse the input–output relationship of neural circuits are developed and applied to dissect the LC-NE circuit in mice, finding that LC- NE neurons projecting to diverse output regions receive mostly similar input.
Journal ArticleDOI
Basal forebrain circuit for sleep-wake control
Min Xu,Shinjae Chung,Siyu Zhang,Peng Zhong,Chenyan Ma,Wei-Cheng Chang,Brandon Weissbourd,Noriaki Sakai,Liqun Luo,Seiji Nishino,Yang Dan +10 more
TL;DR: Recordings from channelrhodopsin-2 (ChR2)-tagged neurons revealed that three BF cell types, cholinergic, glutamatergic and parvalbumin-positive (PV+) GABAergic neurons, were more active during wakefulness and rapid eye movement (REM) sleep than during non-REM sleep, and activation of each cell type rapidly induced wakefulness.
Journal ArticleDOI
Monosynaptic Circuit Tracing with Glycoprotein-Deleted Rabies Viruses
Edward M. Callaway,Liqun Luo +1 more
TL;DR: Using glycoprotein (G)-deleted rabies virus to identify the direct monosynaptic inputs to genetically targeted neurons and this approach has been widely used for sophisticated circuit-tracing.
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Dynamic response of chest wall and lung injuries in rabbits exposed to air shock waves of short duration.
Carl-Johan Clemedson,Joensson A +1 more
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Structure and function of the brain serotonin system.
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A Resource of Cre Driver Lines for Genetic Targeting of GABAergic Neurons in Cerebral Cortex
Hiroki Taniguchi,Miao He,Priscilla Wu,Sangyong Kim,Raehum Paik,Ken Sugino,Duda Kvitsani,Yu Fu,Jiangteng Lu,Ying Lin,Goichi Miyoshi,Yasuyuki Shima,Gord Fishell,Sacha B. Nelson,Z. Josh Huang +14 more
TL;DR: Using genetic engineering in mice, approximately 20 Cre and inducible CreER knockin driver lines that reliably target major classes and lineages of GABAergic neurons are generated, thereby enabling a systematic and comprehensive analysis from cell fate specification, migration, and connectivity, to their functions in network dynamics and behavior.