Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism
Alexander Duscha,Barbara Gisevius,Sarah Hirschberg,Nissan Yissachar,Gabriele I. Stangl,Eva Eilers,Eva Eilers,Verian Bader,Stefanie Haase,Johannes Kaisler,Christina David,Ruth Schneider,Riccardo Troisi,Daniel Zent,Tobias Hegelmaier,Nikolaos Dokalis,Sara Gerstein,Sara Del Mare-Roumani,Sivan Amidror,Ori Staszewski,Gereon Poschmann,Kai Stühler,Frank Hirche,András Balogh,Stefan Kempa,Pascal Träger,Mario M. Zaiss,Jacob Bak Holm,Megan G. Massa,Henrik Nielsen,Andreas Faissner,Carsten Lukas,Sören Gatermann,Markus Scholz,Horst Przuntek,Marco Prinz,Sofia K. Forslund,Konstanze F. Winklhofer,Dominik N. Müller,Ralf A. Linker,Ralf Gold,Aiden Haghikia +41 more
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TLDR
It is suggested that PA can serve as a potent immunomodulatory supplement to MS drugs and as an add-on to MS immunotherapy.About:
This article is published in Cell.The article was published on 2020-03-19 and is currently open access. It has received 301 citations till now.read more
Citations
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Gut Microbiota-Derived Short-Chain Fatty Acids Promote Poststroke Recovery in Aged Mice.
Juneyoung Lee,John d'Aigle,Louise A. Atadja,Victoria Quaicoe,Pedram Honarpisheh,Bhanu P. Ganesh,Ahmad F. Hassan,Joerg Graf,Joseph F. Petrosino,Nagireddy Putluri,Liang Zhu,David J. Durgan,Robert M. Bryan,Louise D. McCullough,Venugopal Reddy Venna +14 more
TL;DR: This is the first study suggesting that the poor stroke recovery in aged mice can be reversed via poststroke bacteriotherapy following the replenishment of youthful gut microbiome via modulation of immunologic, microbial, and metabolomic profiles in the host.
Journal ArticleDOI
Gut microbial molecules in behavioural and neurodegenerative conditions.
TL;DR: Bacterial metabolites with known or suspected neuromodulatory activity are described, mechanisms of signalling pathways from the gut microbiota to the brain are defined and direct effects that gut bacterial molecules are likely exerting on specific brain cells are discussed.
Journal ArticleDOI
Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease
Daniel Erny,Nikolaos Dokalis,Charlotte Mezö,Angela Castoldi,Omar Mossad,Ori Staszewski,Maximilian Frosch,Matteo Villa,Vidmante Fuchs,Arun Mayer,Jana Neuber,Janika Sosat,Stefan Tholen,Oliver Schilling,Andreas Vlachos,Thomas Blank,Mercedes Gomez de Agüero,Andrew J. Macpherson,Edward J. Pearce,Edward J. Pearce,Marco Prinz +20 more
TL;DR: This paper found that the immature phenotype of microglia from germ-free (GF) mice is epigenetically imprinted by H3K4me3 and H3k9ac on metabolic genes associated with substantial functional alterations including increased mitochondrial mass and specific respiratory chain dysfunctions.
Journal ArticleDOI
Dysbiosis of Gut Microbiota and Short-Chain Fatty Acids in Acute Ischemic Stroke and the Subsequent Risk for Poor Functional Outcomes
Chuhong Tan,Qiheng Wu,Huidi Wang,Xuxuan Gao,Ruoting Xu,Ziming Cui,Jiajia Zhu,Xiuli Zeng,Hongwei Zhou,Yan He,Jia Yin +10 more
TL;DR: Dysbiosis of SCFAs‐producing bacteria andSCFAs in AIS patients increased the subsequent risk for poor functional outcomes, indicating that SCFas could be potential prognostic markers and therapeutic targets for stroke.
Journal ArticleDOI
Alterations of the gut ecological and functional microenvironment in different stages of multiple sclerosis.
Daiki Takewaki,Wataru Suda,Wakiro Sato,Lena Takayasu,Naveen Kumar,Kimitoshi Kimura,Naoko Kaga,Toshiki Mizuno,Sachiko Miyake,Masahira Hattori,Takashi Yamamura +10 more
TL;DR: Gut ecological and functional microenvironments were significantly altered in the different stages of MS, and it is postulated that excessive DNA oxidation could take place in the gut of SPMS.
References
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Cutadapt removes adapter sequences from high-throughput sequencing reads
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The SILVA ribosomal RNA gene database project: improved data processing and web-based tools
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