Proteomic diversity of high density lipoproteins: our emerging understanding of its importance in lipid transport and beyond
TLDR
Key challenges facing the field are highlighted, particularly the need to identify and define the function of HDL subspecies to better inform attempts to pharmacologically manipulate HDL for the benefit of cardiovascular disease and possibly other maladies.About:
This article is published in Journal of Lipid Research.The article was published on 2013-10-01 and is currently open access. It has received 308 citations till now.read more
Citations
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Journal ArticleDOI
HDL and Reverse Cholesterol Transport.
TL;DR: On balance, the evidence still argues for further research to better understand how HDL functionality contributes to RCT to develop prevention and treatment strategies to reduce the risk of cardiovascular disease.
Journal ArticleDOI
Quantitative variability of 342 plasma proteins in a human twin population
Yansheng Liu,Alfonso Buil,Ben C. Collins,Ludovic C Gillet,Lorenz C. Blum,Lin-Yang Cheng,Olga Vitek,Jeppe Mouritsen,Genevieve Lachance,Tim D. Spector,Emmanouil T. Dermitzakis,Ruedi Aebersold,Ruedi Aebersold +12 more
TL;DR: The highly accurate and reproducible SWATH mass spectrometry technique is applied to quantify 1,904 peptides defining 342 unique plasma proteins in 232 plasma samples collected longitudinally from pairs of monozygotic and dizygotic twins and identified 13 cis‐SNPs significantly influencing the level of specific plasma proteins.
Journal ArticleDOI
High-density lipoproteins: A consensus statement from the National Lipid Association
Peter P. Toth,Peter P. Toth,Philip J. Barter,Robert S. Rosenson,William E. Boden,M. John Chapman,Marina Cuchel,Ralph B. D'Agostino,Michael H. Davidson,W. Sean Davidson,Jay W. Heinecke,Richard H. Karas,Anatol Kontush,Ronald M. Krauss,Michael Miller,Daniel J. Rader +15 more
TL;DR: In this article, an expert panel was formed to evaluate the current status of HDL-C as a therapeutic target; to review the current state of knowledge of HDL particle structure, composition, and function; and to identify the salient questions yet to be answered about the role of HDL in either preventing or contributing to atherosclerotic disease.
Journal ArticleDOI
High-Density Lipoprotein Vascular Protective Effects, Dysfunction, and Potential as Therapeutic Target
TL;DR: Although HDL is a promising marker and potential therapeutic target based on its epidemiological data and the effects of healthy HDL in vitro in endothelial cells and macrophages, it remains still uncertain whether or not HDL cholesterol-raising drugs will improve outcomes.
Journal ArticleDOI
High-Density Lipoproteins: Nature’s Multifunctional Nanoparticles
TL;DR: Clinical pharmacokinetics and safety of reconstituted HDL products, comparison of HDL with inorganic and other organic nanoparticles, and intrinsic targeting properties to different recipient cells are summarized.
References
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Electrospray ionization for mass spectrometry of large biomolecules
TL;DR: Spectra have been obtained for biopolymers including oligonucleotides and proteins, the latter having molecular weights up to 130,000, with as yet no evidence of an upper limit.
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Effects of Torcetrapib in Patients at High Risk for Coronary Events
Philip J. Barter,Mark J. Caulfield,Mats Eriksson,Scott M. Grundy,John J.P. Kastelein,Michel Komajda,Jose Lopez-Sendon,Lori Mosca,Jean-Claude Tardif,David D. Waters,Charles L. Shear,James H. Revkin,Kevin A. Buhr,Marian R. Fisher,Alan R. Tall,Bryan Brewer +15 more
TL;DR: Although there was evidence of an off-target effect of torcetrapib, it cannot rule out adverse effects related to CETP inhibition, and the trial was terminated prematurely because of an increased risk of death and cardiac events.
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Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy
TL;DR: Among patients with atherosclerotic cardiovascular disease and LDL cholesterol levels of less than 70 mg per deciliter, there was no incremental clinical benefit from the addition of niacin to statin therapy during a 36-month follow-up period, despite significant improvements in HDL cholesterol and triglyceride levels.
Journal ArticleDOI
Effects of Dalcetrapib in Patients with a Recent Acute Coronary Syndrome
Gregory G. Schwartz,Anders G. Olsson,Markus Abt,Christie M. Ballantyne,Philip J. Barter,Jochen Brumm,Bernard R. Chaitman,I. Holme,David Kallend,Lawrence A. Leiter,Eran Leitersdorf,John J.V. McMurray,Hardi Mundl,Stephen J. Nicholls,Prediman K. Shah,Jean-Claude Tardif,R. Scott Wright,R. Scott Wright +17 more
TL;DR: In patients who had had a recent acute coronary syndrome, dalcetrapib increased HDL cholesterol levels but did not reduce the risk of recurrent cardiovascular events.
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Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis
Amit Khera,Marina Cuchel,Margarita de la Llera-Moya,Amrith Rodrigues,Megan F. Burke,Kashif Jafri,Benjamin French,Julie A. Phillips,Megan L. Mucksavage,Robert L. Wilensky,Emile R. Mohler,George H. Rothblat,Daniel J. Rader +12 more
TL;DR: Cholesterol efflux capacity from macrophages, a metric of HDL function, has a strong inverse association with both carotid intima-media thickness and the likelihood of angiographic coronary artery disease, independently of the HDL cholesterol level.
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