rab7 Activity Affects Epidermal Growth Factor:Epidermal Growth Factor Receptor Degradation by Regulating Endocytic Trafficking from the Late Endosome
Brian P. Ceresa,Steven J. Bahr +1 more
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TLDR
It is concluded that rab7 regulates the endocytic trafficking of the EGF·EGFR complex by regulating its lysosomal degradation.About:
This article is published in Journal of Biological Chemistry.The article was published on 2006-01-13 and is currently open access. It has received 155 citations till now. The article focuses on the topics: Epidermal growth factor & Endosome.read more
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PLEKHM1 Regulates Autophagosome-Lysosome Fusion through HOPS Complex and LC3/GABARAP Proteins.
David G. McEwan,Doris Popovic,Andrea Gubas,Seigo Terawaki,Seigo Terawaki,Seigo Terawaki,Hironori Suzuki,Daniela Stadel,Fraser P. Coxon,Diana Miranda de Stegmann,Sagar Bhogaraju,Karthik Maddi,Anja Kirchof,Evelina Gatti,Evelina Gatti,Evelina Gatti,Miep H. Helfrich,Soichi Wakatsuki,Christian Behrends,Philippe Pierre,Philippe Pierre,Philippe Pierre,Ivan Dikic,Ivan Dikic +23 more
TL;DR: Pleckstrin homology domain containing protein family member 1 (PLEKHM1) directly interacts with HOPS complex and contains a LC3-interacting region (LIR) that mediates its binding to autophagosomal membranes.
Journal ArticleDOI
Rab7 Regulates Late Endocytic Trafficking Downstream of Multivesicular Body Biogenesis and Cargo Sequestration
TL;DR: RNA interference is used to identify the exact step RAB7 regulates in the movement of the epidermal growth factor receptor (EGFR) from the cell surface to the lysosome and provide evidence that RAB 7 is required for the transfer of cargo from the LE/MVB to theLysosomes and for endocytic organelle maintenance.
Journal ArticleDOI
Maturation of autophagosomes and endosomes: A key role for Rab7
TL;DR: Rab7 is an effective multifunctional regulator of autophagy and endocytosis, and might hold potential as a therapeutic target against age-related macular degeneration of the eye and Alzheimer's disease.
Journal ArticleDOI
Multiple Roles of the Small GTPase Rab7
Flora Guerra,Cecilia Bucci +1 more
TL;DR: The role and the importance of Rab7 on different cellular pathways and processes are discussed, including its established role in endocytosis and specific functions in neurons.
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Landscape of EGFR Signaling Network in Human Cancers: Biology and Therapeutic Response in Relation to Receptor Subcellular Locations
Woody Han,Hui-Wen Lo +1 more
TL;DR: An emerging line of research is outlined that uncovers and functionally characterizes several novel modes of EGFR signaling that take center stage in the cell nucleus, mitochondrion and other subcellular compartments and contributes to the rationale design for therapeutic strategy that overcomes tumor drug resistance.
References
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Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
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The ErbB signaling network: receptor heterodimerization in development and cancer
TL;DR: The role of ErbB receptors as normal signal transducers and their contribution to the process of malignant transformation during tumor development are concentrated on.
Journal ArticleDOI
Epidermal growth factor receptor: mechanisms of activation and signalling.
Robert N. Jorissen,Francesca Walker,Francesca Walker,Normand Pouliot,Thomas P. J. Garrett,Thomas P. J. Garrett,Colin W. Ward,Colin W. Ward,Antony W. Burgess,Antony W. Burgess +9 more
TL;DR: The structure and function of the EGFR is reviewed, from ligand binding to the initiation of intracellular signalling pathways that lead to changes in the biochemical state of the cell.
Journal ArticleDOI
Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments.
TL;DR: Findings provide evidence that members of the YPT1/SEC4 subfamily of GTP binding proteins are localized to specific exocytic and endocytic subcompartments in mammalian cells.
Journal ArticleDOI
Control of EGF receptor signaling by clathrin-mediated endocytosis.
TL;DR: Endocytic trafficking of activated EGFR plays a critical role not only in attenuating EGFR signaling but also in establishing and controlling specific signaling pathways.