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Open AccessJournal ArticleDOI

Maturation of autophagosomes and endosomes: A key role for Rab7

Juha M.T. Hyttinen, +3 more
- 01 Mar 2013 - 
- Vol. 1833, Iss: 3, pp 503-510
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TLDR
Rab7 is an effective multifunctional regulator of autophagy and endocytosis, and might hold potential as a therapeutic target against age-related macular degeneration of the eye and Alzheimer's disease.
About: 
This article is published in Biochimica et Biophysica Acta.The article was published on 2013-03-01 and is currently open access. It has received 337 citations till now. The article focuses on the topics: Endosome & Endocytosis.

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Compromised MAPK signaling in human diseases: an update

Eunkyung Kim, +1 more
- 18 Feb 2015 - 
TL;DR: Recent research on the roles of MAPK signaling pathways in human diseases, with a focus on cancer and neurodegenerative conditions is summarized.
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Mammalian Autophagy: How Does It Work?

Carla F. Bento, +7 more
- 13 Jun 2016 - 
TL;DR: The key proteins that regulate the process by discussing their roles and how these may be modulated by posttranslational modifications are reviewed and some of the insights these have provided are discussed.
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Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process.

Antero Salminen, +2 more
- 11 Feb 2013 - 
TL;DR: This crosstalk between the SIRT1 and ROS signaling provokes in a context-dependent manner a decline in autophagy and a low-grade inflammatory phenotype, both being common hallmarks of ageing.
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Regulation of autophagy by the Rab GTPase network

X Ao, +2 more
- 17 Jan 2014 - 
TL;DR: New findings regarding the involvement of Rabs in autophagy are summarized and insights regarding future research on the mechanisms of autophagic regulation are provided.
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Multiple Roles of the Small GTPase Rab7

Flora Guerra, +1 more
- 18 Aug 2016 - 
TL;DR: The role and the importance of Rab7 on different cellular pathways and processes are discussed, including its established role in endocytosis and specific functions in neurons.
References
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Journal ArticleDOI

Methods in Mammalian Autophagy Research

Noboru Mizushima, +2 more
- 05 Feb 2010 - 
TL;DR: Methods to monitor autophagy and to modulate autophagic activity are discussed, with a primary focus on mammalian macroautophagy.
Journal ArticleDOI

Autophagy as a Regulated Pathway of Cellular Degradation

Daniel J. Klionsky, +1 more
- 01 Dec 2000 - 
TL;DR: The core protein machinery that is necessary to drive formation and consumption of intermediates in the macroautophagy pathway includes a ubiquitin-like protein conjugation system and a protein complex that directs membrane docking and fusion at the lysosome or vacuole.
Journal ArticleDOI

Rab proteins as membrane organizers

Marino Zerial, +1 more
- 01 Feb 2001 - 
TL;DR: Cellular organelles in the exocytic and endocytic pathways have a distinctive spatial distribution and communicate through an elaborate system of vesiculo-tubular transport.
Journal ArticleDOI

Autophagy and the Integrated Stress Response

Guido Kroemer, +3 more
- 22 Oct 2010 - 
TL;DR: Autophagy is a cell biological process that is a central component of the integrated stress response and can be integrated with other cellular stress responses through parallel stimulation of autophagy and other stress responses by specific stress stimuli.
Journal ArticleDOI

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

Yasemin Sancak, +7 more
- 13 Jun 2008 - 
TL;DR: It is found that the Rag proteins—a family of four related small guanosine triphosphatases (GTPases)—interact with mTORC1 in an amino acid–sensitive manner and are necessary for the activation of the m TORC1 pathway by amino acids.
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