Regulation of epidermal growth factor receptor signaling in human cancer cells by microRNA-7.
Rebecca J. Webster,Keith M. Giles,Karina J. Price,Priscilla M. Zhang,John S. Mattick,Peter J. Leedman +5 more
Reads0
Chats0
TLDR
It is found that miR-7 down-regulates EGFR mRNA and protein expression in cancer cell lines (lung, breast, and glioblastoma) via two of the three sites, inducing cell cycle arrest and cell death.About:
This article is published in Journal of Biological Chemistry.The article was published on 2009-02-27 and is currently open access. It has received 439 citations till now. The article focuses on the topics: Cyclin-dependent kinase 8 & ERBB3.read more
Citations
More filters
Journal ArticleDOI
MicroRNAs in cancer.
TL;DR: In this paper, the effects of miRNA dysregulation in the cellular pathways that lead to the progressive conversion of normal cells into cancer cells and the potential to develop new molecular miRNA-targeted therapies are discussed.
Journal ArticleDOI
Circular RNA and miR-7 in Cancer
TL;DR: The current knowledge about the ciRS-7/miR-7 axis in cancer-related pathways is reviewed and possible models explaining the relevance of coexpressing miR- 7 along with a circRNA inhibitor are discussed.
Journal ArticleDOI
Circular RNAs function as ceRNAs to regulate and control human cancer progression.
Yaxian Zhong,Yaxian Zhong,Yajun Du,Yajun Du,Xue Yang,Xue Yang,Yongzhen Mo,Yongzhen Mo,Chunmei Fan,Fang Xiong,Daixi Ren,Daixi Ren,Xin Ye,Xin Ye,Chunwei Li,Chunwei Li,Yumin Wang,Yumin Wang,Fang Wei,Can Guo,Xu Wu,Xiaoling Li,Xiaoling Li,Yong Li,Yong Li,Guiyuan Li,Guiyuan Li,Zhaoyang Zeng,Zhaoyang Zeng,Wei Xiong,Wei Xiong +30 more
TL;DR: The progress in studying the role of circRNAs as ceRNAs in tumors is reviewed and the participation of circ RNAs in signal transduction pathways to regulate cellular functions is highlighted.
Journal ArticleDOI
Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells
TL;DR: Current progress in understanding how miRNAs execute these effects in animals is reviewed and some of the controversies regarding different modes of miRNA function are discussed.
Journal ArticleDOI
Repression of α-synuclein expression and toxicity by microRNA-7
TL;DR: It is shown that microRNA-7 (miR-7), which is expressed mainly in neurons, represses α- synuclein protein levels through the 3′-untranslated region (UTR) of α-synuclein mRNA, which provides a mechanism by which α- Synuclein levels are regulated in neurons and protects cells against oxidative stress.
References
More filters
Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
Journal ArticleDOI
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
TL;DR: In a four-genome analysis of 3' UTRs, approximately 13,000 regulatory relationships were detected above the estimate of false-positive predictions, thereby implicating as miRNA targets more than 5300 human genes, which represented 30% of the gene set.
Journal Article
Oncomirs : microRNAs with a role in cancer
TL;DR: I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators as discussed by the authors, and have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.
Journal ArticleDOI
A microRNA expression signature of human solid tumors defines cancer gene targets
Stefano Volinia,George A. Calin,Chang Gong Liu,Stefan Ambs,Amelia Cimmino,Fabio Petrocca,Rosa Visone,Marilena V. Iorio,Claudia Roldo,Manuela Ferracin,Robyn L. Prueitt,Nozumu Yanaihara,Giovanni Lanza,Aldo Scarpa,Andrea Vecchione,Massimo Negrini,Curtis C. Harris,Carlo M. Croce +17 more
TL;DR: The results indicate that miRNAs are extensively involved in cancer pathogenesis of solid tumors and support their function as either dominant or recessive cancer genes.
Related Papers (5)
A microRNA expression signature of human solid tumors defines cancer gene targets
MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more