Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance
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TLDR
A critical eye is turned toward both DAGs and ceramides as putative mediators of lipid-induced hepatic insulin resistance, with various genetic and pharmacologic manipulations yielding a vast and occasionally contradictory trove of data to sort.About:
This article is published in Trends in Pharmacological Sciences.The article was published on 2017-07-01 and is currently open access. It has received 227 citations till now. The article focuses on the topics: Insulin resistance & Insulin receptor.read more
Citations
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Journal ArticleDOI
Mechanisms of Insulin Action and Insulin Resistance
TL;DR: This work aims to develop an integrated physiological perspective, placing the intricate signaling effectors that carry out the cell-autonomous response to insulin in the context of the tissue-specific functions that generate the coordinated organismal response.
Journal ArticleDOI
Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications
Michele Longo,Federica Zatterale,Federica Zatterale,Jamal Naderi,Jamal Naderi,Luca Parrillo,Luca Parrillo,Pietro Formisano,Pietro Formisano,Gregory Alexander Raciti,Gregory Alexander Raciti,Francesco Beguinot,Francesco Beguinot,Claudia Miele,Claudia Miele +14 more
TL;DR: A better understanding of the mechanisms regulating adipose tissue expansion in obesity is required for the development of future therapeutic approaches in obesity-associated metabolic complications.
Journal ArticleDOI
Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies.
TL;DR: This Review highlights novel concepts related to diagnosis, risk prediction, and treatment of non-alcoholic fatty liver disease that could contribute to the development of a multidisciplinary approach for endocrinologists and hepatologists working together in the management of NAFLD.
Journal ArticleDOI
Nonalcoholic Fatty Liver Disease and Risk of Incident Type 2 Diabetes: A Meta-analysis
TL;DR: NAFLD is significantly associated with a twofold increased risk of incident diabetes, however, the observational design of the eligible studies does not allow for proving causality.
Journal ArticleDOI
Metabolites as regulators of insulin sensitivity and metabolism
TL;DR: A comprehensive understanding of the metabolic adaptations involved in insulin resistance may enable the identification of novel targets for improving insulin sensitivity and preventing, and treating, T2DM.
References
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Journal ArticleDOI
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
Bolormaa Vandanmagsar,Yun-Hee Youm,Anthony Ravussin,Jose E. Galgani,Krisztian Stadler,Randall L. Mynatt,Eric Ravussin,Jacqueline M. Stephens,Vishwa Deep Dixit +8 more
TL;DR: It is established that calorie restriction and exercise-mediated weight loss in obese individuals with type 2 diabetes is associated with a reduction in adipose tissue expression of Nlrp3 as well as with decreased inflammation and improved insulin sensitivity, and that the NlrP3 inflammasome senses obesity-associated danger signals and contributes to obesity-induced inflammation and insulin resistance.
Journal ArticleDOI
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
Jorge Henao-Mejia,Eran Elinav,Chengcheng Jin,Liming Hao,Wajahat Z. Mehal,Till Strowig,Christoph A. Thaiss,Andrew L. Kau,Stephanie C. Eisenbarth,Michael J. Jurczak,Joao Paulo Camporez,Gerald I. Shulman,Gerald I. Shulman,Jeffrey I. Gordon,Hal M. Hoffman,Richard A. Flavell,Richard A. Flavell +16 more
TL;DR: Altered interactions between the gut microbiota and the host, produced by defective NLRP3 and NLRP6 inflammasome sensing, may govern the rate of progression of multiple metabolic syndrome-associated abnormalities, highlighting the central role of the microbiota in the pathogenesis of heretofore seemingly unrelated systemic auto-inflammatory and metabolic disorders.
Journal ArticleDOI
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
Qin Yang,Timothy E. Graham,Nimesh Mody,Frédéric Preitner,Odile D. Peroni,Janice M. Zabolotny,Ko Kotani,Loredana Quadro,Barbara B. Kahn +8 more
TL;DR: It is shown that expression of retinol binding protein-4 (RBP4) is elevated in adipose tissue of adipose-Glut4-/- mice and RBP4 is an adipocyte-derived ‘signal’ that may contribute to the pathogenesis of type 2 diabetes.
Journal ArticleDOI
Association of nonalcoholic fatty liver disease with insulin resistance
Giulio Marchesini,Mara Brizi,Antonio Maria Morselli-Labate,Giampaolo Bianchi,Elisabetta Bugianesi,Arthur J. McCullough,Gabriele Forlani,Nazario Melchionda +7 more
TL;DR: Nonalcoholic fatty liver disease is associated with insulin resistance and hyperinsulinemia even in lean subjects with normal glucose tolerance, and genetic factors that reduce insulin sensitivity and increase serum triglyceride levels may be responsible for its development.
Journal ArticleDOI
Mechanism of Hepatic Insulin Resistance in Non-alcoholic Fatty Liver Disease
Varman T. Samuel,Zhen Xiang Liu,Xianqin Qu,Benjamin Elder,Stefan Bilz,Douglas E. Befroy,Anthony J. Romanelli,Gerald I. Shulman,Gerald I. Shulman +8 more
TL;DR: The hypothesis hepatic steatosis leads to hepatic insulin resistance by stimulating gluconeogenesis and activating PKC-ϵ and JNK1, which may interfere with tyrosine phosphorylation of IRS-1 and IRS-2 and impair the ability of insulin to activate glycogen synthase is supported.
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