SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies.
Markus Hoffmann,Markus Hoffmann,Prerna Arora,Prerna Arora,Rüdiger Groß,Alina Seidel,Bojan F. Hörnich,Alexander S. Hahn,Nadine Krüger,Luise Graichen,Heike Hofmann-Winkler,Amy Kempf,Amy Kempf,Martin Sebastian Winkler,Sebastian R. Schulz,Hans-Martin Jäck,Bernd Jahrsdörfer,Bernd Jahrsdörfer,Hubert Schrezenmeier,Hubert Schrezenmeier,Martin Müller,Alexander Kleger,Jan Münch,Stefan Pöhlmann,Stefan Pöhlmann +24 more
TLDR
In this article, the authors show that SARS-CoV-2/COVID-19 variants B.1.7 (UK), B.351 (South Africa), and P.1 (Brazil) harbor mutations in the viral spike (S) protein that may alter virus-host cell interactions and confer resistance to inhibitors and antibodies.About:
This article is published in Cell.The article was published on 2021-04-29 and is currently open access. It has received 754 citations till now. The article focuses on the topics: Neutralizing antibody.read more
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IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern
Matthew T. Chang,Luke M. Tomasovic,Natalia Kuzmina,Adam J. Ronk,Patrick O. Byrne,Rebecca I. Johnson,Nadia Storm,Eduardo Olmedillas,Yixuan J. Hou,Alexandra Schäfer,Sarah R. Leist,Longping V. Tse,Hanzhong Ke,Christian D. Coherd,Katrina Nguyen,Maliwan Kamkaew,Anna N. Honko,Quan Zhu,Galit Alter,Erica Ollmann Saphire,Jason S. McLellan,Anthony Griffiths,Ralph S. Baric,Alexander Bukreyev,Wayne A. Marasco +24 more
TL;DR: In this article , the authors presented two anti-SARS-CoV-2 spike binding antibodies, one Class 1 and one Class 4, selected from our non-immune human single-chain variable fragment (scFv) phage library, that are engineered into four, fully-human IgG-like bispecific antibodies (BsAb).
Journal ArticleDOI
Back to the past: Are anatomy online classes reminiscent of the anatomy theaters of old?
Boon-Huat Bay,Wojciech Pawlina +1 more
TL;DR: The Anatomy of Dr Nicholaes Tulp by Rembrandt van Rijn as discussed by the authors is one of the most famous examples of anatomical detail and muscle function in a painting, which can be viewed at the Royal Picture Gallery Mauritshuis in The Netherlands.
Journal ArticleDOI
Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants
Lili Li,Meiling Gao,Peng Jiao,Shulong Zu,Yongqiang Deng,Dingyi Wan,Yang Cao,Jing Duan,Saba Roghiyh Aliyari,Jie Li,Yueyue Shi,Zihe Rao,Cheng-Feng Qin,Yu Guo,Genhong Cheng,Heng Yang +15 more
TL;DR: In this article , a strategy to identify and engineer neutralizing antibodies against SARS-CoV-2 variants was outlined, and the R3P1-E4 mAb was found to have selectively reduced binding and neutralizing activity.
Journal ArticleDOI
Pilot Investigation of SARS-CoV-2 Variants in the Island of Sicily Prior to and in the Second Wave of the COVID-19 Pandemic
Miguel Padilla-Blanco,Francesca Gucciardi,Annalisa Guercio,Vicente Rubio,Antonina Princiotta,Veronica Veses,Mariangela Terrana,Chirag C. Sheth,Marina Pascual-Ortiz,Elisa Maiques,Giuseppa Purpari,Consuelo Rubio-Guerri +11 more
TL;DR: The results shed some light on SARS-CoV-2 variant circulation during that wave in this insular region of Italy which combines its partial insular isolation with being a major entry point for the African immigration.
Posted ContentDOI
Single-domain antibodies efficiently neutralize SARS-CoV-2 variants of concern
Irina A Favorskaya,Dmitry V. Shcheblyakov,Ilias B Esmagambetov,Inna V. Dolzhikova,Irina A Alekseeva,Anastasia I Korobkova,Daria V Voronina,Ekaterina I Ryabova,Artem A Derkaev,Anna V. Kovyrshina,Anna A. Iliukhina,Andrey G Botikov,Olga L. Voronina,Daria A. Egorova,Olga V. Zubkova,Natalia N. Ryzhova,Ekaterina I. Aksenova,M.S. Kunda,Denis Y. Logunov,Boris S. Naroditsky,Alexandr L. Gintsburg +20 more
TL;DR: In this article, a panel of single-domain antibodies that specifically bind to the receptor-binding domain of SARS-CoV-2 S glycoprotein were isolated and used to generate dimeric molecules.
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Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.
Fernando P. Polack,Stephen J. Thomas,Nicholas Kitchin,Judith Absalon,Alejandra Gurtman,Stephen Lockhart,John L. Perez,Gonzalo Pérez Marc,Edson D. Moreira,Cristiano Zerbini,Ruth Bailey,Kena A. Swanson,Satrajit Roychoudhury,Kenneth Koury,Ping Li,Warren Kalina,David A. Cooper,Robert W. Frenck,Laura L. Hammitt,Özlem Türeci,Haylene Nell,Axel Schaefer,Serhat Ünal,Dina B. Tresnan,Susan Mather,Philip R. Dormitzer,Ugur Sahin,Kathrin U. Jansen,William C. Gruber +28 more
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Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus.
Bette T. Korber,Will Fischer,Sandrasegaram Gnanakaran,Hyejin Yoon,James Theiler,Werner Abfalterer,Nick Hengartner,Elena E. Giorgi,Tanmoy Bhattacharya,Brian T. Foley,Kathryn M. Hastie,Matthew Parker,David G Partridge,Cariad Evans,Timothy M. Freeman,Thushan I de Silva,Adrienne Angyal,Rebecca Brown,Laura Carrilero,Luke R. Green,Luke R. Green,Luke R. Green,Danielle C. Groves,Katie Johnson,Alexander J Keeley,Benjamin B Lindsey,Paul J. Parsons,Mohammad Raza,Sarah Rowland-Jones,Nikki Smith,Rachel Tucker,Dennis Wang,Matthew Wyles,Charlene McDanal,Lautaro G. Perez,Haili Tang,Alex Moon-Walker,Alex Moon-Walker,Alex Moon-Walker,Sean P. J. Whelan,Celia C. LaBranche,Erica Ollmann Saphire,David C. Montefiori +42 more
TL;DR: A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic, and it is found that the G614 variant grows to higher titer as pseudotyped virions.
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Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals.
Alba Grifoni,Daniela Weiskopf,Sydney I. Ramirez,Sydney I. Ramirez,Jose Mateus,Jennifer M. Dan,Jennifer M. Dan,Carolyn Rydyznski Moderbacher,Stephen A. Rawlings,Aaron Sutherland,Lakshmanane Premkumar,Ramesh Jadi,Daniel Marrama,Aravinda M. de Silva,April Frazier,Aaron F. Carlin,Jason A. Greenbaum,Bjoern Peters,Bjoern Peters,Florian Krammer,Davey M. Smith,Shane Crotty,Shane Crotty,Alessandro Sette,Alessandro Sette +24 more
TL;DR: Using HLA class I and II predicted peptide ‘megapools’, circulating SARS-CoV-2−specific CD8+ and CD4+ T cells were identified in ∼70% and 100% of COVID-19 convalescent patients, respectively, suggesting cross-reactive T cell recognition between circulating ‘common cold’ coronaviruses and SARS.
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