SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies.
Markus Hoffmann,Markus Hoffmann,Prerna Arora,Prerna Arora,Rüdiger Groß,Alina Seidel,Bojan F. Hörnich,Alexander S. Hahn,Nadine Krüger,Luise Graichen,Heike Hofmann-Winkler,Amy Kempf,Amy Kempf,Martin Sebastian Winkler,Sebastian R. Schulz,Hans-Martin Jäck,Bernd Jahrsdörfer,Bernd Jahrsdörfer,Hubert Schrezenmeier,Hubert Schrezenmeier,Martin Müller,Alexander Kleger,Jan Münch,Stefan Pöhlmann,Stefan Pöhlmann +24 more
TLDR
In this article, the authors show that SARS-CoV-2/COVID-19 variants B.1.7 (UK), B.351 (South Africa), and P.1 (Brazil) harbor mutations in the viral spike (S) protein that may alter virus-host cell interactions and confer resistance to inhibitors and antibodies.About:
This article is published in Cell.The article was published on 2021-04-29 and is currently open access. It has received 754 citations till now. The article focuses on the topics: Neutralizing antibody.read more
Citations
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Emerging SARS-CoV-2 Variants: A Review of Its Mutations, Its Implications and Vaccine Efficacy.
Sindhu Ramesh,Manoj Govindarajulu,Rachel S. Parise,Logan Neel,Tharanath Shankar,Shriya Patel,Payton Lowery,Forrest Smith,Muralikrishnan Dhanasekaran,Timothy Moore +9 more
TL;DR: In this article, the authors discuss the different SARS-CoV-2 variants, emphasizing variants of concern circulating the world and highlight the various mutations and how these mutations affect the characteristics of the virus.
Journal ArticleDOI
Emerging SARS-CoV-2 Variants of Concern (VOCs): An Impending Global Crisis.
Angel Yun-Kuan Thye,Jodi Woan-Fei Law,Priyia Pusparajah,Vengadesh Letchumanan,Kok-Gan Chan,Learn Han Lee +5 more
TL;DR: In this article, the authors discuss the key mutations present in the SARS-CoV-2 strains and provide insights into how these mutations allow for greater transmissibility and immune evasion than the progenitor strain.
Posted ContentDOI
Variant SARS-CoV-2 mRNA vaccines confer broad neutralization as primary or booster series in mice
Kai Wu,Angela Choi,Matthew A. Koch,Sayda Elbashir,LingZhi Ma,Diana Lee,Angela Woods,Carole Henry,Charis Palandjian,Anna Hill,Julian Quinones,Naveen Nunna,Sarah O’Connell,Adrian B. McDermott,Samantha Falcone,Elisabeth Narayanan,Tonya M. Colpitts,Hamilton Bennett,Kizzmekia S. Corbett,Robert A. Seder,Barney S. Graham,Guillaume Stewart-Jones,Andrea Carfi,Darin K. Edwards +23 more
TL;DR: In this paper, the authors evaluated two updated COVID-19 mRNA vaccines designed to target emerging SARS-CoV-2 variants: (1) monovalent mRNA-1273.351 encodes for the S protein found in the B.1.351 lineage and (2) mRNA- 1273.211 was most effective at providing broad cross-variant neutralization in mice.
Journal ArticleDOI
Monoclonal antibody therapies against SARS-CoV-2
TL;DR: Tabll et al. as mentioned in this paper reviewed the properties of mAbs and their effect as therapeutics in the COVID-19 pandemic, including structural classification, outcomes in clinical trials that led to the authorisation of mabs, and baseline and treatment-emergent immune escape.
Journal ArticleDOI
Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies.
Claudia A. Jette,Alexander A. Cohen,Priyanthi N. P. Gnanapragasam,Frauke Muecksch,Yu E. Lee,Kathryn E. Huey-Tubman,Fabian Schmidt,Theodora Hatziioannou,Paul D. Bieniasz,Paul D. Bieniasz,Michel C. Nussenzweig,Michel C. Nussenzweig,Anthony P. West,Jennifer R. Keeffe,Pamela J. Bjorkman,Christopher O. Barnes +15 more
TL;DR: Two class 4 anti-RBD antibodies derived from COVID-19 donors that exhibit breadth and potent neutralization of zoonotic coronaviruses and SARS-CoV-2 variants are characterized and potential advantages of class 4 RBD-binding antibody therapeutics are illustrated.
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TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
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TL;DR: A two-dose regimen of BNT162b2 conferred 95% protection against Covid-19 in persons 16 years of age or older and safety over a median of 2 months was similar to that of other viral vaccines.
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Bette T. Korber,Will Fischer,Sandrasegaram Gnanakaran,Hyejin Yoon,James Theiler,Werner Abfalterer,Nick Hengartner,Elena E. Giorgi,Tanmoy Bhattacharya,Brian T. Foley,Kathryn M. Hastie,Matthew Parker,David G Partridge,Cariad Evans,Timothy M. Freeman,Thushan I de Silva,Adrienne Angyal,Rebecca Brown,Laura Carrilero,Luke R. Green,Luke R. Green,Luke R. Green,Danielle C. Groves,Katie Johnson,Alexander J Keeley,Benjamin B Lindsey,Paul J. Parsons,Mohammad Raza,Sarah Rowland-Jones,Nikki Smith,Rachel Tucker,Dennis Wang,Matthew Wyles,Charlene McDanal,Lautaro G. Perez,Haili Tang,Alex Moon-Walker,Alex Moon-Walker,Alex Moon-Walker,Sean P. J. Whelan,Celia C. LaBranche,Erica Ollmann Saphire,David C. Montefiori +42 more
TL;DR: A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic, and it is found that the G614 variant grows to higher titer as pseudotyped virions.
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Alba Grifoni,Daniela Weiskopf,Sydney I. Ramirez,Sydney I. Ramirez,Jose Mateus,Jennifer M. Dan,Jennifer M. Dan,Carolyn Rydyznski Moderbacher,Stephen A. Rawlings,Aaron Sutherland,Lakshmanane Premkumar,Ramesh Jadi,Daniel Marrama,Aravinda M. de Silva,April Frazier,Aaron F. Carlin,Jason A. Greenbaum,Bjoern Peters,Bjoern Peters,Florian Krammer,Davey M. Smith,Shane Crotty,Shane Crotty,Alessandro Sette,Alessandro Sette +24 more
TL;DR: Using HLA class I and II predicted peptide ‘megapools’, circulating SARS-CoV-2−specific CD8+ and CD4+ T cells were identified in ∼70% and 100% of COVID-19 convalescent patients, respectively, suggesting cross-reactive T cell recognition between circulating ‘common cold’ coronaviruses and SARS.
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