SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies.
Markus Hoffmann,Markus Hoffmann,Prerna Arora,Prerna Arora,Rüdiger Groß,Alina Seidel,Bojan F. Hörnich,Alexander S. Hahn,Nadine Krüger,Luise Graichen,Heike Hofmann-Winkler,Amy Kempf,Amy Kempf,Martin Sebastian Winkler,Sebastian R. Schulz,Hans-Martin Jäck,Bernd Jahrsdörfer,Bernd Jahrsdörfer,Hubert Schrezenmeier,Hubert Schrezenmeier,Martin Müller,Alexander Kleger,Jan Münch,Stefan Pöhlmann,Stefan Pöhlmann +24 more
TLDR
In this article, the authors show that SARS-CoV-2/COVID-19 variants B.1.7 (UK), B.351 (South Africa), and P.1 (Brazil) harbor mutations in the viral spike (S) protein that may alter virus-host cell interactions and confer resistance to inhibitors and antibodies.About:
This article is published in Cell.The article was published on 2021-04-29 and is currently open access. It has received 754 citations till now. The article focuses on the topics: Neutralizing antibody.read more
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Isolation and characterization of SARS-CoV-2 VOC, 20H/501Y.V2, from UAE travelers
Pragya D Yadav,Prasad Sarkale,Alpana Razdan,Nivedita Gupta,Dimpal A Nyayanit,Rima R Sahay,Varsha Potdar,Deepak Y. Patil,Shreekant Baradkar,Abhinendra Kumar,Neeraj Aggarwal,Anita M. Shete,Harmanmeet Kaur +12 more
TL;DR: In this paper, the authors report the isolation and characterization of SARS-CoV-2 VOC, 20H/501Y.V2 (B.1.351) from UAE travelers to India.
Book ChapterDOI
Broad-spectrum Respiratory Virus Entry Inhibitors.
Hanjun Zhao,Kwok-Yung Yuen +1 more
TL;DR: This chapter mainly focuses on discussing the risks of respiratory viruses, the challenge of finding broad-spectrum antivirals, the entry processes of respiratory virus, the current studies on broad-Spectrum entry inhibitors for respiratory diseases, and the directions for discovering broad- Spectrum antiviral drugs in the future.
Posted ContentDOI
High Frequencies of PD-1+TIM3+TIGIT+CTLA4+ Functionally Exhausted SARS-CoV-2-Specific CD4+ and CD8+ T Cells Associated with Severe Disease in Critically ill COVID-19 Patients
Philippe Coulon,Swayam Prakash,Nisha R Dhanushkodi,Ruchi Srivastava,Latifa Zayou,Delia F. Tifrea,Robert Edwards,J.-F. Cesar,Sebastian D. Schubl,Lanny Hsieh,Anthony B. Nesburn,Baruch D. Kuppermann,Elmostafa Bahraoui,Hawa Vahed,Daniel Gil,Trevor M Jones,Jeffrey B. Ulmer,Lbachir BenMohamed +17 more
TL;DR: Interestingly, the cross-reactive SARS-CoV-2 epitopes that recalled the strongest CD4+ and CD8+ T cell responses in unexposed healthy donors (HD) were the most strongly associated with better disease outcome seen in asymptomatic COVID-19 patients.
Posted ContentDOI
Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD
Hang Ma,Yingying Guo,Haoneng Tang,Chien-Te Tseng,Lei Wang,Huifang Zong,Wang Zhenyu,Yang He,Yunsong Chang,Shusheng Wang,Haiqiu Huang,Yong Ke,Yunsheng Yuan,Mingyuan Wu,Yuanyuan Zhang,Aleksandra Drelich,Kempaiah Rayavara Kempaiah,Bi Hung Peng,Ailin Wang,Kaiyong Yang,Haiyang Yin,Junjun Liu,Yali Yue,Wenbo Xu,Shuangli Zhu,Tianjiao Ji,Gang Li,Guangchun Liu,Jingjing Song,Lingling Mu,ZongShang Xiang,Zhangyi Song,Hua Chen,Yanlin Bian,Baohong Zhang,Chen Hui,Jiawei Zhang,Yunji Liao,Li Zhang,John Gilly,Xiaodong Xiao,Lei Han,Hua Jiang,Yueqing Xie,Qiang Zhou,Jianwei Zhu +45 more
TL;DR: In this article, a monoclonal antibody, 2G1, was proposed to neutralize all current SARS-CoV-2 variants and has surprising tolerance to mutations adjacent to or within its interaction epitope.
Posted ContentDOI
Redox regulation of the SARS-CoV-2 main protease provides new opportunities for drug design
Lisa-Marie Funk,Gereon Poschmann,Ashwin Chari,Fabian Rabe von Pappenheim,Kim M. Stegmann,Antje Dickmanns,Nora K. Eulig,M. Wensien,Elham Paknia,Gabi Heyne,Elke Penka,Arwen R. Pearson,Carsten Berndt,Tobias Fritz,Sophia Bazzi,Jon Uranga,Ricardo A. Mata,Matthias Dobbelstein,Rolf Hilgenfeld,Ute Curth,Kai Tittmann +20 more
TL;DR: It is shown that Mpro is subject to redox regulation and reversibly switches between the enzymatically active dimer and the functionally dormant monomer through redox modifications of cysteine residues, which is required for structural stability under oxidative stress conditions, such as those exerted by the innate immune system.
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TL;DR: A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic, and it is found that the G614 variant grows to higher titer as pseudotyped virions.
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Alba Grifoni,Daniela Weiskopf,Sydney I. Ramirez,Sydney I. Ramirez,Jose Mateus,Jennifer M. Dan,Jennifer M. Dan,Carolyn Rydyznski Moderbacher,Stephen A. Rawlings,Aaron Sutherland,Lakshmanane Premkumar,Ramesh Jadi,Daniel Marrama,Aravinda M. de Silva,April Frazier,Aaron F. Carlin,Jason A. Greenbaum,Bjoern Peters,Bjoern Peters,Florian Krammer,Davey M. Smith,Shane Crotty,Shane Crotty,Alessandro Sette,Alessandro Sette +24 more
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