SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies.
Markus Hoffmann,Markus Hoffmann,Prerna Arora,Prerna Arora,Rüdiger Groß,Alina Seidel,Bojan F. Hörnich,Alexander S. Hahn,Nadine Krüger,Luise Graichen,Heike Hofmann-Winkler,Amy Kempf,Amy Kempf,Martin Sebastian Winkler,Sebastian R. Schulz,Hans-Martin Jäck,Bernd Jahrsdörfer,Bernd Jahrsdörfer,Hubert Schrezenmeier,Hubert Schrezenmeier,Martin Müller,Alexander Kleger,Jan Münch,Stefan Pöhlmann,Stefan Pöhlmann +24 more
TLDR
In this article, the authors show that SARS-CoV-2/COVID-19 variants B.1.7 (UK), B.351 (South Africa), and P.1 (Brazil) harbor mutations in the viral spike (S) protein that may alter virus-host cell interactions and confer resistance to inhibitors and antibodies.About:
This article is published in Cell.The article was published on 2021-04-29 and is currently open access. It has received 754 citations till now. The article focuses on the topics: Neutralizing antibody.read more
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CHARM: COVID-19 Health Action Response for Marines–Association of antigen-specific interferon-gamma and IL2 responses with asymptomatic and symptomatic infections after a positive qPCR SARS-CoV-2 test
Martha Sedegah,Chad K. Porter,Michael R. Hollingdale,Harini Ganeshan,Jun Huang,Carl Goforth,Maria Belmonte,Arnel Belmonte,Dawn L. Weir,Rhonda A. Lizewski,Stephen E. Lizewski,Stuart C. Sealfon,Vihasi Jani,Ying Cheng,Sandra Inoue,Rachael Velasco,Eileen Villasante,Peifang Sun,Andrew G. Letizia +18 more
TL;DR: Assessment of T cell responses against S, N and M proteins in symptomatic and asymptomatic SARS-CoV-2 infected participants helps support the central role of Th1-biased cell mediated immunity IFN-γ and IL2 responses, particularly to the N protein, in controlling COVID-19 symptoms, and justify T cell-based CO VID-19 vaccines that include the N and S proteins.
Journal ArticleDOI
SARS-CoV-2 Lineage P.4 Detection in Southeast Brazil: A Retrospective Genomic and Clinical Overview
Mirele Daiana Poleti,Jessika Cristina Chagas Lesbon,Elisângela Chicaroni de Mattos Oliveira,José S. L. Patané,Luan Gaspar Clemente,Vincent Louis Viala,Gabriela Ribeiro,Jéssica Fernanda Perissato Pinheiro,Marta Giovanetti,Luiz Carlos Junior Alcantara,Loyze Paola Oliveira de Lima,Antonio Jorge Martins,Claudia Renata Dos Santos Barros,Elaine Cristina Marqueze,Jardelina de Souza Todão Bernardino,Débora Botéquio Moretti,Ricardo Augusto Brassaloti,Raquel de Lello Rocha Campos Cassano,Pilar Drummond Sampaio Corrêa Mariani,Svetoslav Nanev Slavov,Rafael dos Santos Bezerra,Evandra Strazza Rodrigues,E. V. Santos,Josiane Serrano Borges,Debora Glenda Lima de La Roque,João Paulo Kitajima,Bibiana Santos,Patricia Akemi Assato,Felipe Allan da Silva da Costa,C. A. Banho,Lívia Sacchetto,Beatriz de Carvalho Marques,Rejane Maria Tommasini Grotto,Jayme A. Souza-Neto,Maurício Lacerda Nogueira,Luiz Lehmann Coutinho,Rodrigo T. Calado,Raul Machado Neto,Dimas Tadeu Covas,Simone Kashima,M.C. Elias,Sandra Coccuzzo Sampaio,Heidge Fukumasu +42 more
TL;DR: In this paper , the authors analyzed 17,304 genome sequences of SARS-CoV-2 sampled between February and August of 2021 in 476 distinct cities in São Paulo, assessing the transmission dynamics of the P.4 lineage and other variants that were co-circulating in the state.
Posted ContentDOI
Long-term immune protection against SARS-CoV-2 escape variants upon a single vaccination with murine cytomegalovirus expressing the spike protein
Yeon Soo Kim,Henning Jacobsen,Bettina Fuerholzner,Kathrin Eschke,Markus Hoffmann,M. Zeeshan Chaudhry,Federico Bertoglio,Michael Hust,Marek Widera,Sandra Ciesek,Stefan Pöhlmann,Luka Cicin-Sain +11 more
TL;DR: In this article , a single dose of a murine cytomegalovirus (MCMV)-based vaccine, which expresses the spike (S) protein of the virus circulating early in the pandemic, protects highly susceptible K18hACE2 mice from clinical symptoms and death upon challenge with a lethal dose of D614G SARS-CoV-2.1.
Journal ArticleDOI
Heterologous SARS-CoV-2 spike protein booster elicits durable and broad antibody responses against the receptor-binding domain
Tomohiro Takano,Takashi Sato,Ryutaro Kotaki,Saya Moriyama,Shuetsu Fukushi,Masahiro Shinoda,Kiyomi Kabasawa,Nagashige Shimada,Mio Kousaka,Yu Adachi,Taishi Onodera,Kazutaka Terahara,Masanori Isogawa,Takayuki Matsumura,Masaharu Shinkai,Yoshimasa Takahashi +15 more
TL;DR: In this paper , longitudinal analysis reveals more sustained SARS-CoV-2 spike receptor-binding domain (RBD)-binding IgG titers with the breadth to antigenically distinct variants by the S-268019-b spike protein booster compared to the BNT162b2 mRNA homologous booster.
Posted ContentDOI
An ultrapotent neutralizing bispecific antibody with broad spectrum against SARS-CoV-2 variants
Hui Zhang,Haohui Huang,Rong Li,Lu Zhang,Zhiwei Wang,Jiaping Li,Junyou Chen,Huafei Su,Dandan Zheng,Ziqi Su,Li Wang,Chunping Deng,shujun Pei,Shenghua Zhu,Chan Li,Yaochang Yuan,Haitao Yue,Yanqun Wang,Xiaobo Li,Cuihua Liu,Jinchen Yu,Shengfeng Li,Huang Xianming +22 more
TL;DR: A bispecific antibody, 2022, consisting of two antibodies, 2F8 and VHH18, was developed in this article to neutralize SARS-CoV-2 and all of the variants tested in both pseudovirus and live virus assays.
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Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.
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TL;DR: A two-dose regimen of BNT162b2 conferred 95% protection against Covid-19 in persons 16 years of age or older and safety over a median of 2 months was similar to that of other viral vaccines.
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Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus.
Bette T. Korber,Will Fischer,Sandrasegaram Gnanakaran,Hyejin Yoon,James Theiler,Werner Abfalterer,Nick Hengartner,Elena E. Giorgi,Tanmoy Bhattacharya,Brian T. Foley,Kathryn M. Hastie,Matthew Parker,David G Partridge,Cariad Evans,Timothy M. Freeman,Thushan I de Silva,Adrienne Angyal,Rebecca Brown,Laura Carrilero,Luke R. Green,Luke R. Green,Luke R. Green,Danielle C. Groves,Katie Johnson,Alexander J Keeley,Benjamin B Lindsey,Paul J. Parsons,Mohammad Raza,Sarah Rowland-Jones,Nikki Smith,Rachel Tucker,Dennis Wang,Matthew Wyles,Charlene McDanal,Lautaro G. Perez,Haili Tang,Alex Moon-Walker,Alex Moon-Walker,Alex Moon-Walker,Sean P. J. Whelan,Celia C. LaBranche,Erica Ollmann Saphire,David C. Montefiori +42 more
TL;DR: A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic, and it is found that the G614 variant grows to higher titer as pseudotyped virions.
Journal ArticleDOI
Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals.
Alba Grifoni,Daniela Weiskopf,Sydney I. Ramirez,Sydney I. Ramirez,Jose Mateus,Jennifer M. Dan,Jennifer M. Dan,Carolyn Rydyznski Moderbacher,Stephen A. Rawlings,Aaron Sutherland,Lakshmanane Premkumar,Ramesh Jadi,Daniel Marrama,Aravinda M. de Silva,April Frazier,Aaron F. Carlin,Jason A. Greenbaum,Bjoern Peters,Bjoern Peters,Florian Krammer,Davey M. Smith,Shane Crotty,Shane Crotty,Alessandro Sette,Alessandro Sette +24 more
TL;DR: Using HLA class I and II predicted peptide ‘megapools’, circulating SARS-CoV-2−specific CD8+ and CD4+ T cells were identified in ∼70% and 100% of COVID-19 convalescent patients, respectively, suggesting cross-reactive T cell recognition between circulating ‘common cold’ coronaviruses and SARS.
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