SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies.
Markus Hoffmann,Markus Hoffmann,Prerna Arora,Prerna Arora,Rüdiger Groß,Alina Seidel,Bojan F. Hörnich,Alexander S. Hahn,Nadine Krüger,Luise Graichen,Heike Hofmann-Winkler,Amy Kempf,Amy Kempf,Martin Sebastian Winkler,Sebastian R. Schulz,Hans-Martin Jäck,Bernd Jahrsdörfer,Bernd Jahrsdörfer,Hubert Schrezenmeier,Hubert Schrezenmeier,Martin Müller,Alexander Kleger,Jan Münch,Stefan Pöhlmann,Stefan Pöhlmann +24 more
TLDR
In this article, the authors show that SARS-CoV-2/COVID-19 variants B.1.7 (UK), B.351 (South Africa), and P.1 (Brazil) harbor mutations in the viral spike (S) protein that may alter virus-host cell interactions and confer resistance to inhibitors and antibodies.About:
This article is published in Cell.The article was published on 2021-04-29 and is currently open access. It has received 754 citations till now. The article focuses on the topics: Neutralizing antibody.read more
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Experimental Models of COVID-19
Luis A. Caldera-Crespo,Michael J. Paidas,Sabita Roy,Carl I. Schulman,Norma S. Kenyon,Sylvia Daunert,Arumugam R. Jayakumar +6 more
TL;DR: Balancing safety, mimicking human COVID-19 and robustness of the animal model, the Murine Hepatitis Virus-1 Murine model currently represents the most optimal model for SARS-CoV-2/COVID19 research.
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High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells
Craig B. Wilen,Virva Kinnunen +1 more
TL;DR: In this paper , the authors found that TFH-dependent and -independent antibodies were induced against SARS-CoV-2 infection and influenza A virus infection by epitope mapping and B cell receptor sequencing.
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Nasally delivered interferon-λ protects mice against infection by SARS-CoV-2 variants including Omicron
Zhenlu Chong,Courtney E. Karl,Peter Halfmann,Yoshihiro Kawaoka,Emma S. Winkler,Shamus P. Keeler,Michael J. Holtzman,Jinsheng Yu,Michael S. Diamond +8 more
TL;DR: In this article , the host-derived cytokine interferon lambda (IFN-λ) has been proposed as a possible treatment based on studies in human coronavirus 2019 (COVID-19) patients.
Journal ArticleDOI
A Unique SARS-CoV-2 Spike Protein P681H Variant Detected in Israel
Neta S Zuckerman,Shay Fleishon,Efrat Bucris,Dana Bar-Ilan,Michal Linial,Itay Bar-Or,Victoria Indenbaum,Merav Weil,Yaniv Lustig,Ella Mendelson,Ella Mendelson,Michal Mandelboim,Michal Mandelboim,Orna Mor,Orna Mor,Neta S. Zuckerman +15 more
TL;DR: A local variant with a non-synonymous mutation in the spike (S) protein P681H was reported in this article, which was not associated with a higher infection rate or higher prevalence.
Journal ArticleDOI
Germline IGHV3-53-encoded RBD-targeting neutralizing antibodies are commonly present in the antibody repertoires of COVID-19 patients.
Qihong Yan,Ping He,Ping He,Xiaohan Huang,Xiaohan Huang,Kun Luo,Kun Luo,Yudi Zhang,Yudi Zhang,Haisu Yi,Qian Wang,Feng Li,Ruitian Hou,Ruitian Hou,Xiaodi Fan,Pingchao Li,Xinglong Liu,Huan Liang,Yijun Deng,Zhaoming Chen,Yunfei Chen,Xiaoneng Mo,Liqiang Feng,Xiaoli Xiong,Song Li,Jian Han,Linbing Qu,Xuefeng Niu,Ling Chen,Ling Chen +29 more
TL;DR: In this paper, the existence and prevalence of monoclonal antibodies encoded by IGHV3-53 targeting the spike receptor-binding domain (RBD) have been isolated from different COVID-19 patients.
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TL;DR: A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic, and it is found that the G614 variant grows to higher titer as pseudotyped virions.
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TL;DR: Using HLA class I and II predicted peptide ‘megapools’, circulating SARS-CoV-2−specific CD8+ and CD4+ T cells were identified in ∼70% and 100% of COVID-19 convalescent patients, respectively, suggesting cross-reactive T cell recognition between circulating ‘common cold’ coronaviruses and SARS.
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