SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies.
Markus Hoffmann,Markus Hoffmann,Prerna Arora,Prerna Arora,Rüdiger Groß,Alina Seidel,Bojan F. Hörnich,Alexander S. Hahn,Nadine Krüger,Luise Graichen,Heike Hofmann-Winkler,Amy Kempf,Amy Kempf,Martin Sebastian Winkler,Sebastian R. Schulz,Hans-Martin Jäck,Bernd Jahrsdörfer,Bernd Jahrsdörfer,Hubert Schrezenmeier,Hubert Schrezenmeier,Martin Müller,Alexander Kleger,Jan Münch,Stefan Pöhlmann,Stefan Pöhlmann +24 more
TLDR
In this article, the authors show that SARS-CoV-2/COVID-19 variants B.1.7 (UK), B.351 (South Africa), and P.1 (Brazil) harbor mutations in the viral spike (S) protein that may alter virus-host cell interactions and confer resistance to inhibitors and antibodies.About:
This article is published in Cell.The article was published on 2021-04-29 and is currently open access. It has received 754 citations till now. The article focuses on the topics: Neutralizing antibody.read more
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Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant.
Jun Zhang,Tianshu Xiao,Tianshu Xiao,Yongfei Cai,Yongfei Cai,Christy L. Lavine,Hanqin Peng,Haisun Zhu,Krishna Anand,Pei Tong,Avneesh Gautam,Avneesh Gautam,Megan L. Mayer,Richard M. Walsh,Sophia Rits-Volloch,Duane R. Wesemann,Duane R. Wesemann,Wei Yang,Michael S. Seaman,Jianming Lu,Bing Chen,Bing Chen +21 more
TL;DR: The Delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a dominant strain worldwide as discussed by the authors, and the structure, func...
Journal ArticleDOI
Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics.
Michael I Barton,Stuart A. MacGowan,Mikhail A Kutuzov,Omer Dushek,Geoffrey J. Barton,P. Anton van der Merwe +5 more
TL;DR: Bart Barton et al. as discussed by the authors measured the effect of mutations in Spike and ACE2 on the strength of the interaction between the two proteins and found that three of the five common Spike mutations in the Alpha, Beta and Gamma SARS-CoV-2 variants strengthened binding to ACE2.
Journal ArticleDOI
Effectiveness of the CoronaVac vaccine in older adults during a gamma variant associated epidemic of covid-19 in Brazil: test negative case-control study.
Otavio T. Ranzani,Matthew D. Hitchings,Murilo Dorion,Tatiana Lang D'Agostini,Regiane Cardoso de Paula,Olivia Ferreira Pereira de Paula,Edlaine Faria de Moura Villela,Mario Sergio Scaramuzzini Torres,Silvano Barbosa de Oliveira,Silvano Barbosa de Oliveira,Wade L. Schulz,Maria Almiron,Rodrigo Fabiano do Carmo Said,Roberto Dias de Oliveira,Patricia Vieira da Silva,Wildo Navegantes de Araújo,Wildo Navegantes de Araújo,Jean Carlo Gorinchteyn,Jason R. Andrews,Derek A. T. Cummings,Albert I. Ko,Albert I. Ko,Julio Croda,Julio Croda,Julio Croda +24 more
TL;DR: In this paper, the authors estimate the effectiveness of the inactivated whole virus vaccine, CoronaVac, against symptomatic covid-19 in the elderly population of Sao Paulo state, Brazil during widespread circulation of the gamma variant.
Journal ArticleDOI
SARS-CoV-2 variant B.1.617 is resistant to bamlanivimab and evades antibodies induced by infection and vaccination.
Markus Hoffmann,Markus Hoffmann,Heike Hofmann-Winkler,Nadine Krüger,Amy Kempf,Amy Kempf,Inga Nehlmeier,Luise Graichen,Luise Graichen,Prerna Arora,Prerna Arora,Anzhalika Sidarovich,Anzhalika Sidarovich,Anna-Sophie Moldenhauer,Martin Sebastian Winkler,Sebastian R. Schulz,Hans-Martin Jäck,Metodi V. Stankov,Georg M. N. Behrens,Stefan Pöhlmann,Stefan Pöhlmann +20 more
TL;DR: In this paper, the authors analyzed whether B.1.617 is more adept in entering cells and/or evades antibody responses, and they found that antibody evasion may contribute to the rapid spread of this variant.
Journal ArticleDOI
Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species.
Ruoke Wang,Qi Zhang,Jiwan Ge,Wenlin Ren,Rui Zhang,Jun Lan,Bin Ju,Bin Su,Fengting Yu,Peng Chen,Huiyu Liao,Yingmei Feng,Xuemei Li,Xuanling Shi,Zheng Zhang,Fujie Zhang,Qiang Ding,Qiang Ding,Tong Zhang,Xinquan Wang,Linqi Zhang,Linqi Zhang +21 more
TL;DR: In this article, the authors showed that the South African variant B.1.351 was the most resistant to current monoclonal antibodies and convalescent plasma from coronavirus disease 2019 (COVID-19)-infected individuals.
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Bette T. Korber,Will Fischer,Sandrasegaram Gnanakaran,Hyejin Yoon,James Theiler,Werner Abfalterer,Nick Hengartner,Elena E. Giorgi,Tanmoy Bhattacharya,Brian T. Foley,Kathryn M. Hastie,Matthew Parker,David G Partridge,Cariad Evans,Timothy M. Freeman,Thushan I de Silva,Adrienne Angyal,Rebecca Brown,Laura Carrilero,Luke R. Green,Luke R. Green,Luke R. Green,Danielle C. Groves,Katie Johnson,Alexander J Keeley,Benjamin B Lindsey,Paul J. Parsons,Mohammad Raza,Sarah Rowland-Jones,Nikki Smith,Rachel Tucker,Dennis Wang,Matthew Wyles,Charlene McDanal,Lautaro G. Perez,Haili Tang,Alex Moon-Walker,Alex Moon-Walker,Alex Moon-Walker,Sean P. J. Whelan,Celia C. LaBranche,Erica Ollmann Saphire,David C. Montefiori +42 more
TL;DR: A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic, and it is found that the G614 variant grows to higher titer as pseudotyped virions.
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Alba Grifoni,Daniela Weiskopf,Sydney I. Ramirez,Sydney I. Ramirez,Jose Mateus,Jennifer M. Dan,Jennifer M. Dan,Carolyn Rydyznski Moderbacher,Stephen A. Rawlings,Aaron Sutherland,Lakshmanane Premkumar,Ramesh Jadi,Daniel Marrama,Aravinda M. de Silva,April Frazier,Aaron F. Carlin,Jason A. Greenbaum,Bjoern Peters,Bjoern Peters,Florian Krammer,Davey M. Smith,Shane Crotty,Shane Crotty,Alessandro Sette,Alessandro Sette +24 more
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