Sex Differences in Alzheimer’s Disease: Insights From the Multiomics Landscape
TLDR
In this paper , the impact of sex chromosomes and sex hormones on Alzheimer's disease was discussed, and the interplay between sex and a major AD genetic risk factor, the APOE ε4 genotype, through the multiomics landscape.About:
This article is published in Biological Psychiatry.The article was published on 2022-01-01 and is currently open access. It has received 34 citations till now. The article focuses on the topics: Biology & Disease.read more
Citations
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Exploring Sex-Related Differences in Microglia May Be a Game-Changer in Precision Medicine
TL;DR: This review will consider how age impacts on sex-related differences in microglia and ask whether the advancement of personalized medicine demands that a greater focus is placed on studying sex- related differences inmicroglia in Alzheimer's disease, Parkinson’s disease and models of inflammatory stress and trauma in order to make true progress in dealing with these conditions.
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Predictive metabolic networks reveal sex‐ and APOE genotype‐specific metabolic signatures and drivers for precision medicine in Alzheimer's disease
Rui Chang,Eugenia Trushina,Kuixi Zhu,Syed Shujaat Ali Zaidi,Branden Lau,Alexandra Kueider-Paisley,Sara Moein,Qianying He,Melissa Alamprese,Barbora Vagnerova,Andrew Tang,Ramachandran Vijayan,Yanyun Liu,Andrew J. Saykin,Roberta Diaz Brinton,Rima Kaddurah-Daouk +15 more
TL;DR: These findings provide an initial but critical step in developing a diagnostic platform for personalized medicine by integrating metabolomic profiling and cognitive assessments to identify targeted precision therapeutics for AD patient subgroups through computational network modeling.
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Long noncoding RNA XIST: Mechanisms for X chromosome inactivation, roles in sex-biased diseases, and therapeutic opportunities
TL;DR: In this paper , the authors summarize the current knowledge about the mechanisms for XIST-mediated XCI and the roles of XIST in sex-biased diseases, and discuss potential therapeutic strategies targeting XIST.
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The Emergence of Model Systems to Investigate the Link Between Traumatic Brain Injury and Alzheimer’s Disease
TL;DR: This review will discuss the various in vivo and in vitro models that are being employed to provide more definite mechanistic relationships between TBI-induced mechanical injury and AD-related phenotypes and how emerging methods including the use of human induced pluripotent stem cell (hiPSC)-derived cultures and genome engineering technologies can be employed to generate better models of TBO-induced AD.
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Impact of Behavioral Assessment and Re-Test as Functional Trainings That Modify Survival, Anxiety and Functional Profile (Physical Endurance and Motor Learning) of Old Male and Female 3xTg-AD Mice and NTg Mice with Normal Aging
TL;DR: In the AD-genotype, females achieved the best performance in physical endurance and motor learning, while males showed a deterioration in most studied variables.
References
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Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation
Nuala A. O'Leary,Mathew W. Wright,J. Rodney Brister,Stacy Ciufo,Diana Haddad,Richard McVeigh,Bhanu Rajput,Barbara Robbertse,Brian Smith-White,Danso Ako-adjei,Alexander Astashyn,Azat Badretdin,Yiming Bao,Olga Blinkova,Vyacheslav Brover,Vyacheslav Chetvernin,Jinna Choi,Eric Cox,Olga Ermolaeva,Catherine M. Farrell,Tamara Goldfarb,Tripti Gupta,Daniel H. Haft,Eneida L. Hatcher,Wratko Hlavina,Vinita Joardar,Vamsi K. Kodali,Wenjun Li,Donna Maglott,Patrick Masterson,Kelly M. McGarvey,Michael R. Murphy,Kathleen O'Neill,Shashikant Pujar,Sanjida H. Rangwala,Daniel Rausch,Lillian D. Riddick,Conrad L. Schoch,Andrei Shkeda,Susan S. Storz,Hanzhen Sun,Françoise Thibaud-Nissen,Igor Tolstoy,Raymond E. Tully,Anjana R. Vatsan,Craig Wallin,David Webb,Wendy Wu,Melissa J. Landrum,Avi Kimchi,Tatiana Tatusova,Michael DiCuccio,Paul Kitts,Terence Murphy,Kim D. Pruitt +54 more
TL;DR: The approach to utilizing available RNA-Seq and other data types in the authors' manual curation process for vertebrate, plant, and other species is summarized, and a new direction for prokaryotic genomes and protein name management is described.
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Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis
Lindsay A. Farrer,L. Adrienne Cupples,Jonathan L. Haines,Bradley T. Hyman,Walter A. Kukull,Richard Mayeux,Richard H. Myers,Margaret A. Pericak-Vance,Neil Risch,Cornelia M. van Duijn +9 more
TL;DR: The APOE∈4 allele represents a major risk factor for AD in all ethnic groups studied, across all ages between 40 and 90 years, and in both men and women.
Journal ArticleDOI
Sex differences in immune responses
Sabra L. Klein,Katie L. Flanagan +1 more
TL;DR: It is emphasized that sex is a biological variable that should be considered in immunological studies and contribute to variations in the incidence of autoimmune diseases and malignancies, susceptibility to infectious diseases and responses to vaccines in males and females.
Journal ArticleDOI
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
Hadas Keren-Shaul,Amit Spinrad,Assaf Weiner,Assaf Weiner,Orit Matcovitch-Natan,Raz Dvir-Szternfeld,Tyler K. Ulland,Eyal David,Kuti Baruch,David Lara-Astaiso,Beáta Tóth,Shalev Itzkovitz,Marco Colonna,Michal Schwartz,Ido Amit +14 more
TL;DR: A novel microglia type associated with neurodegenerative diseases (DAM) is described and it is revealed that the DAM program is activated in a two-step process that involves downregulation of microglian checkpoints, followed by activation of a Trem2-dependent program.
Journal ArticleDOI
Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial.
Sally A. Shumaker,Claudine Legault,Stephen R. Rapp,Leon J. Thal,Robert B. Wallace,Judith K. Ockene,Susan L. Hendrix,Beverly N. Jones,Annlouise R. Assaf,Rebecca D. Jackson,Jane Morley Kotchen,Sylvia Wassertheil-Smoller,Jean Wactawski-Wende +12 more
TL;DR: Estrogen plus progestin therapy increased the risk for probable dementia in postmenopausal women aged 65 years or older and did not prevent mild cognitive impairment in these women, supporting the conclusion that the risks of estrogen plus progESTin outweigh the benefits.