Journal ArticleDOI
Sleep function and synaptic homeostasis.
Giulio Tononi,Chiara Cirelli +1 more
TLDR
This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis, which accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders.About:
This article is published in Sleep Medicine Reviews.The article was published on 2006-02-01. It has received 1864 citations till now. The article focuses on the topics: Synaptic scaling & Sleep and memory.read more
Citations
More filters
Journal ArticleDOI
Traveling Slow Oscillations During Sleep: A Marker of Brain Connectivity in Childhood
Salome Kurth,Brady A. Riedner,Douglas C. Dean,Jonathan O'Muircheartaigh,Reto Huber,Oskar G. Jenni,Sean C.L. Deoni,Monique K. LeBourgeois +7 more
TL;DR: Age-related changes in slow oscillation propagation distance, as well as regional associations between brain activity during sleep and the anatomical connectivity of white matter microstructure are demonstrated.
Journal ArticleDOI
Sleep Enforces the Temporal Order in Memory
TL;DR: It is demonstrated that consolidation during sleep strengthens the original temporal sequence structure in memory, presumably as a result of a replay of new representations during sleep in forward direction, which suggests that the temporally directed replay of memory during sleep could be the key mechanism that explains how temporal order is integrated and maintained in the trace of an episodic memory.
Journal ArticleDOI
Local use-dependent sleep.
TL;DR: The paradigm represented by the articles in this issue offers testable hypotheses for the mechanisms underlying these phenomena and suggests that sleep is indeed self-organizing and a property of any viable neuronal network.
Journal ArticleDOI
The memory function of noradrenergic activity in non-rem sleep
TL;DR: It is concluded that noradrenergic activity during non-REM sleep interacts with other sleep-related mechanisms to functionally contribute to off-line memory consolidation and enhances memory retention.
Journal ArticleDOI
Effects of Anesthesia on the Response to Sleep Deprivation
TL;DR: The blunted SWA rebound after ISO-sw and DES-sw suggests that anesthesia slow waves may substitute for sleep slow waves, and may suggest that anesthesiaslow waves are not an absolute requirement to discharge sleep pressure.
References
More filters
Book
Psychopharmacology: The Fourth Generation of Progress
Floyd E. Bloom,David J. Kupfer +1 more
TL;DR: Part 1 Preclinical section: critical analysis of methods transmitter systems - amino acids, amines, peptides, new transmitterscritical analysis of integrative concepts.
Journal ArticleDOI
An Energy Budget for Signaling in the Grey Matter of the Brain
David Attwell,Simon B. Laughlin +1 more
TL;DR: The estimates of energy usage predict the use of distributed codes, with ≤15% of neurons simultaneously active, to reduce energy consumption and allow greater computing power from a fixed number of neurons.
Journal ArticleDOI
Regional differences in synaptogenesis in human cerebral cortex.
TL;DR: Findings in the human resemble those in rhesus monkeys, including overproduction of synaptic contacts in infancy, persistence of high levels of synaptic density to late childhood or adolescence, the absolute values of maximum and adult synaptic density, and layer specific differences.
Journal ArticleDOI
The Cumulative Cost of Additional Wakefulness: Dose-Response Effects on Neurobehavioral Functions and Sleep Physiology From Chronic Sleep Restriction and Total Sleep Deprivation
TL;DR: It appears that even relatively moderate sleep restriction can seriously impair waking neurobehavioral functions in healthy adults, and sleep debt is perhaps best understood as resulting in additional wakefulness that has a neurobiological "cost" which accumulates over time.
Journal ArticleDOI
Reactivation of hippocampal ensemble memories during sleep.
TL;DR: In this paper, large ensembles of hippocampal "place cells" were recorded from three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors, showing an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks.