Journal ArticleDOI
Sleep function and synaptic homeostasis.
Giulio Tononi,Chiara Cirelli +1 more
TLDR
This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis, which accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders.About:
This article is published in Sleep Medicine Reviews.The article was published on 2006-02-01. It has received 1864 citations till now. The article focuses on the topics: Synaptic scaling & Sleep and memory.read more
Citations
More filters
Journal ArticleDOI
Impaired slow wave sleep downscaling in encephalopathy with status epilepticus during sleep (ESES).
Bigna K. Bölsterli,Bernhard Schmitt,Thomas Bast,Hanne Critelli,Jakob Heinzle,Oskar G. Jenni,Reto Huber +6 more
TL;DR: The findings contribute to the understanding of the pathomechanisms leading to the regression observed in children with ESES and support the view that the goal of the treatment in childrenwith ESES should not only be to reduce seizures, but also to resolve the continuous spike wave activity.
Journal ArticleDOI
The genome-wide landscape of DNA methylation and hydroxymethylation in response to sleep deprivation impacts on synaptic plasticity genes
Renaud Massart,Marlène Freyburger,Matthew Suderman,Jean Paquet,J El Helou,Erika Bélanger-Nelson,A Rachalski,O C Koumar,Julie Carrier,M Szyf,Valérie Mongrain +10 more
TL;DR: It is shown here that Nlgn1 mutant mice display an enhanced slow-wave slope during non-rapid eye movement sleep following SD but this mutation does not affect SD-dependent changes in gene expression, suggesting that the N lgn pathway acts downstream to mechanisms triggering gene expression changes in SD.
Journal ArticleDOI
Sleep recalibrates homeostatic and associative synaptic plasticity in the human cortex
Marion Kuhn,Elias Wolf,Jonathan G. Maier,Florian Mainberger,Bernd Feige,Hanna Schmid,Jan Bürklin,Sarah Maywald,Volker Mall,Nikolai H. Jung,Janine Reis,Kai Spiegelhalder,Stefan Klöppel,Annette Sterr,Anne Eckert,Dieter Riemann,Claus Normann,Christoph Nissen +17 more
TL;DR: It is indicated that sleep recalibrates homeostatic and associative synaptic plasticity, believed to be the neural basis for adaptive behaviour, in humans after sleep and sleep deprivation.
Journal ArticleDOI
Neurocognitive biases and the patterns of spontaneous correlations in the human cortex
Tal Harmelech,Rafael Malach +1 more
TL;DR: The hypothesis that the correlation patterns among these spontaneous fluctuations (SPs) reflect the profile of individual a priori cognitive biases, coded as synaptic efficacies in cortical networks, offers a new means for mapping personal traits in both neurotypical and atypical cases.
Journal ArticleDOI
Hippocampal memory consolidation during sleep: a comparison of mammals and birds.
TL;DR: Avian sleep does not appear to be involved in transferring hippocampal memories to other brain regions, and the slow‐oscillation, the defining feature of mammalian and avian SWS, may serve a more general function independent of that related to coordinating the transfer of information from the hippocampus to the PFC in mammals.
References
More filters
Book
Psychopharmacology: The Fourth Generation of Progress
Floyd E. Bloom,David J. Kupfer +1 more
TL;DR: Part 1 Preclinical section: critical analysis of methods transmitter systems - amino acids, amines, peptides, new transmitterscritical analysis of integrative concepts.
Journal ArticleDOI
An Energy Budget for Signaling in the Grey Matter of the Brain
David Attwell,Simon B. Laughlin +1 more
TL;DR: The estimates of energy usage predict the use of distributed codes, with ≤15% of neurons simultaneously active, to reduce energy consumption and allow greater computing power from a fixed number of neurons.
Journal ArticleDOI
Regional differences in synaptogenesis in human cerebral cortex.
TL;DR: Findings in the human resemble those in rhesus monkeys, including overproduction of synaptic contacts in infancy, persistence of high levels of synaptic density to late childhood or adolescence, the absolute values of maximum and adult synaptic density, and layer specific differences.
Journal ArticleDOI
The Cumulative Cost of Additional Wakefulness: Dose-Response Effects on Neurobehavioral Functions and Sleep Physiology From Chronic Sleep Restriction and Total Sleep Deprivation
TL;DR: It appears that even relatively moderate sleep restriction can seriously impair waking neurobehavioral functions in healthy adults, and sleep debt is perhaps best understood as resulting in additional wakefulness that has a neurobiological "cost" which accumulates over time.
Journal ArticleDOI
Reactivation of hippocampal ensemble memories during sleep.
TL;DR: In this paper, large ensembles of hippocampal "place cells" were recorded from three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors, showing an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks.