Journal ArticleDOI
Sleep function and synaptic homeostasis.
Giulio Tononi,Chiara Cirelli +1 more
TLDR
This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis, which accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders.About:
This article is published in Sleep Medicine Reviews.The article was published on 2006-02-01. It has received 1864 citations till now. The article focuses on the topics: Synaptic scaling & Sleep and memory.read more
Citations
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Journal ArticleDOI
The role of NREM sleep instability in child cognitive performance.
Oliviero Bruni,Mark Kohler,Mark Kohler,Luana Novelli,Declan Kennedy,Declan Kennedy,Kurt Lushington,James Martin,Raffaele Ferri +8 more
TL;DR: This study shows that CAP analysis provides important insights on the role of EEG slow oscillations (CAP A1) in cognitive performance, as well as significant predictors of nonverbal fluid reasoning in test scores, respectively.
Journal ArticleDOI
Regulation of hippocampal dendritic spines following sleep deprivation
Barbara Gisabella,Barbara Gisabella,Thomas E. Scammell,Sathyajit S. Bandaru,Clifford B. Saper +4 more
TL;DR: 3D quantification suggests sleep contributes to region‐ and branch‐specific synaptic downscaling in the hippocampus, supporting the theory of broad but selective synapticDownscaling during sleep.
Journal ArticleDOI
Insufficient sleep: Enhanced risk-seeking relates to low local sleep intensity.
Angelina Maric,Eszter Montvai,Esther Werth,Matthias Storz,Janina Leemann,Sebastian Weissengruber,Christian C. Ruff,Reto Huber,Rositsa Poryazova,Christian R. Baumann +9 more
TL;DR: It is shown that chronic sleep restriction reflects every‐day sleep loss better than acute sleep deprivation, but its effects and particularly the underlying mechanisms remain largely unknown for a variety of critical cognitive domains, as, for example, risky decision making.
Journal ArticleDOI
Whole blood genome-wide gene expression profile in males after prolonged wakefulness and sleep recovery
Renata Pellegrino,D. Y. Sunaga,Camila Guindalini,Raquel Cristina Silva Martins,Diego R. Mazzotti,Zhi Wei,Z. J. Daye,Monica L. Andersen,Sergio Tufik +8 more
TL;DR: In silico validation of alterations in the expression of CETN3, DNAJC, and CEACAM genes confirmed previous findings related to the molecular effects of sleep deprivation, and confirmed that the effects ofSleep loss are not restricted to the brain and can occur intensely in peripheral tissues.
Journal ArticleDOI
Behavioural exposure and sleep do not modify corticospinal and intracortical excitability in the human motor system.
TL;DR: Results provide no support for the hypothesis that synapses within the motor cortex undergo potentiation due to daytime use and behavioural experiences and provide evidence that measurement of motor cortical excitability is not systematically biased by time-of-day dependent variability and thus does not pose a confound in studies assessing corticospinal excitability longitudinally.
References
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Book
Psychopharmacology: The Fourth Generation of Progress
Floyd E. Bloom,David J. Kupfer +1 more
TL;DR: Part 1 Preclinical section: critical analysis of methods transmitter systems - amino acids, amines, peptides, new transmitterscritical analysis of integrative concepts.
Journal ArticleDOI
An Energy Budget for Signaling in the Grey Matter of the Brain
David Attwell,Simon B. Laughlin +1 more
TL;DR: The estimates of energy usage predict the use of distributed codes, with ≤15% of neurons simultaneously active, to reduce energy consumption and allow greater computing power from a fixed number of neurons.
Journal ArticleDOI
Regional differences in synaptogenesis in human cerebral cortex.
TL;DR: Findings in the human resemble those in rhesus monkeys, including overproduction of synaptic contacts in infancy, persistence of high levels of synaptic density to late childhood or adolescence, the absolute values of maximum and adult synaptic density, and layer specific differences.
Journal ArticleDOI
The Cumulative Cost of Additional Wakefulness: Dose-Response Effects on Neurobehavioral Functions and Sleep Physiology From Chronic Sleep Restriction and Total Sleep Deprivation
TL;DR: It appears that even relatively moderate sleep restriction can seriously impair waking neurobehavioral functions in healthy adults, and sleep debt is perhaps best understood as resulting in additional wakefulness that has a neurobiological "cost" which accumulates over time.
Journal ArticleDOI
Reactivation of hippocampal ensemble memories during sleep.
TL;DR: In this paper, large ensembles of hippocampal "place cells" were recorded from three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors, showing an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks.