Journal ArticleDOI
Sleep function and synaptic homeostasis.
Giulio Tononi,Chiara Cirelli +1 more
TLDR
This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis, which accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders.About:
This article is published in Sleep Medicine Reviews.The article was published on 2006-02-01. It has received 1864 citations till now. The article focuses on the topics: Synaptic scaling & Sleep and memory.read more
Citations
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Journal ArticleDOI
Differential effects of L- and D-lactate on memory encoding and consolidation: Potential role of HCAR1 signaling
TL;DR: Examination of the effects on of systemic administration of both L- and D-lactate as well as the specific HCAR1 agonist 3,5-dihydroxybenzoic acid across the pre- and post-training periods suggest different roles for lactate at different memory stages.
Journal ArticleDOI
Emergence of Sensory Patterns during Sleep Highlights Differential Dynamics of REM and Non-REM Sleep Stages
Michal Ramot,Lior Fisch,Ido Davidesco,Michal Harel,Svetlana Kipervasser,Fani Andelman,Miri Y. Neufeld,Uri Kramer,Itzhak Fried,Itzhak Fried,Rafael Malach +10 more
TL;DR: The results reveal that intricate spatial patterns of sensory functional organization emerge in a stage-specific manner during sleep, whereby the repertoire of such patterns was significantly larger during rapid eye movement (REM) sleep compared with non-REM stages.
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Valproic acid but not D-cycloserine facilitates sleep-dependent offline learning of extinction and habituation of conditioned fear in humans.
TL;DR: It is suggested that DCS and VPA might enhance exposure-based cognitive therapy for anxiety disorders and PTSD by reducing the vulnerability to reinstatement and preventing relapses of fear-conditioned responses, and evidence for a peculiarity of the sleep-dependent off-line learning process for conditioned fear extinction is provided.
Journal ArticleDOI
Microglial circadian clock regulation of microglial structural complexity, dendritic spine density and inflammatory response.
TL;DR: Observations suggest that the microglial clock system disruption contribute to pathogeneses of sleep disturbance, impaired social interaction and cognitive impairment, and the growing understanding of theMicroglial molecular circadian molecular clock might aid in the development of novel pharmacological interventions against both neuropsychiatric and neurodegenerative disorders.
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Slow EEG Amplitude Oscillations During NREM Sleep and Reading Disabilities in Children With Dyslexia
Oliviero Bruni,Raffaele Ferri,Luana Novelli,Elena Finotti,Monica Terribili,Miriam Troianiello,Donatella Valente,Ugo Sabatello,Paolo Curatolo +8 more
TL;DR: To overcome reading difficulties, dyslexic subjects overactivate thalamocortical and hippocampal circuitry to transfer information between cortical posterior and anterior areas and to correlate CAP parameters with neuropsychological measures.
References
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Book
Psychopharmacology: The Fourth Generation of Progress
Floyd E. Bloom,David J. Kupfer +1 more
TL;DR: Part 1 Preclinical section: critical analysis of methods transmitter systems - amino acids, amines, peptides, new transmitterscritical analysis of integrative concepts.
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An Energy Budget for Signaling in the Grey Matter of the Brain
David Attwell,Simon B. Laughlin +1 more
TL;DR: The estimates of energy usage predict the use of distributed codes, with ≤15% of neurons simultaneously active, to reduce energy consumption and allow greater computing power from a fixed number of neurons.
Journal ArticleDOI
Regional differences in synaptogenesis in human cerebral cortex.
TL;DR: Findings in the human resemble those in rhesus monkeys, including overproduction of synaptic contacts in infancy, persistence of high levels of synaptic density to late childhood or adolescence, the absolute values of maximum and adult synaptic density, and layer specific differences.
Journal ArticleDOI
The Cumulative Cost of Additional Wakefulness: Dose-Response Effects on Neurobehavioral Functions and Sleep Physiology From Chronic Sleep Restriction and Total Sleep Deprivation
TL;DR: It appears that even relatively moderate sleep restriction can seriously impair waking neurobehavioral functions in healthy adults, and sleep debt is perhaps best understood as resulting in additional wakefulness that has a neurobiological "cost" which accumulates over time.
Journal ArticleDOI
Reactivation of hippocampal ensemble memories during sleep.
TL;DR: In this paper, large ensembles of hippocampal "place cells" were recorded from three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors, showing an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks.